Search Results - "Rosensweig, Clark"

Periodicity, repression, and the molecular architecture of the mammalian circadian clock by Rosensweig, Clark, Green, Carla B.

“…Large molecular machines regulate daily cycles of transcriptional activity and help generate rhythmic behavior. In recent years, structural and biochemical…”
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SleepMat: a new behavioral analysis software program for sleep and circadian rhythms by Sisobhan, Shiju, Rosensweig, Clark, Lear, Bridget C, Allada, Ravi

“…Abstract Study Objectives To develop a new publicly available software SleepMat that analyzes Drosophila Activity Monitoring system data. Methods The software…”
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Circadian programming of the ellipsoid body sleep homeostat in Drosophila by Andreani, Tomas, Rosensweig, Clark, Sisobhan, Shiju, Ogunlana, Emmanuel, Kath, William, Allada, Ravi

“…Homeostatic and circadian processes collaborate to appropriately time and consolidate sleep and wake. To understand how these processes are integrated, we…”
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An evolutionary hotspot defines functional differences between CRYPTOCHROMES by Rosensweig, Clark, Reynolds, Kimberly A., Gao, Peng, Laothamatas, Isara, Shan, Yongli, Ranganathan, Rama, Takahashi, Joseph S., Green, Carla B.

“…Mammalian circadian clocks are driven by a transcription/translation feedback loop composed of positive regulators (CLOCK/BMAL1) and repressors (CRYPTOCHROME…”
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Temperature-driven coordination of circadian transcriptional regulation by Xu, Bingxian, Hwangbo, Dae-Sung, Saurabh, Sumit, Rosensweig, Clark, Allada, Ravi, Kath, William L, Braun, Rosemary

“…The circadian clock is an evolutionarily-conserved molecular oscillator that enables species to anticipate rhythmic changes in their environment. At a…”
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Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex by Nangle, Shannon N, Rosensweig, Clark, Koike, Nobuya, Tei, Hajime, Takahashi, Joseph S, Green, Carla B, Zheng, Ning

“…The mammalian circadian clock is driven by a transcriptional-translational feedback loop, which produces robust 24-hr rhythms. Proper oscillation of the clock…”
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Monoclonal antibody successes in the clinic by Reichert, Janice M, Rosensweig, Clark J, Faden, Laura B, Dewitz, Matthew C

“…Most monoclonal antibodies in clinical trials are owned by small biotech companies. But with blockbuster-sized revenues and approval rates higher than those…”
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Phosphorylation of the Cryptochrome 1 C-terminal Tail Regulates Circadian Period Length by Gao, Peng, Yoo, Seung-Hee, Lee, Kyung-Jong, Rosensweig, Clark, Takahashi, Joseph S., Chen, Benjamin P., Green, Carla B.

“…The Cryptochrome (CRY) proteins are critical components of the mammalian circadian clock and act to rhythmically repress the activity of the transcriptional…”
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Circadian Clocks, Daily Stress, and Neurodegenerative Disease by Nyamugenda, Eugene, Rosensweig, Clark, Allada, Ravi

“…Disrupted circadian or 24-h rhythms are among the most common early findings in a wide range of neurodegenerative disorders. Once thought to be a mere…”
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Grape-Derived Polyphenolics Prevent A beta Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease by Wang, Jun, Ho, Lap, Zhao, Wei, Ono, Kenjiro, Rosensweig, Clark, Chen, Linghong, Humala, Nelson, Teplow, David B, Pasinetti, Giulio M

“…Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive impairments in memory and cognition. Extracellular accumulation of…”
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A subclass of evening cells promotes the switch from arousal to sleep at dusk by Brown, Matthew P, Verma, Shubha, Palmer, Isabelle, Guerrero Zuniga, Adler, Mehta, Anuradha, Rosensweig, Clark, Keles, Mehmet F, Wu, Mark N

“…Animals exhibit rhythmic patterns of behavior that are shaped by an internal circadian clock and the external environment. Although light intensity varies…”
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Preparation of stable amyloid β-protein oligomers of defined assembly order by Rosensweig, Clark, Ono, Kenjiro, Murakami, Kazuma, Lowenstein, Devin K, Bitan, Gal, Teplow, David B

“…Oligomeric assemblies of the amyloid β-protein, Aβ, are thought to be the proximate neurotoxic agents in Alzheimer's disease (AD). Oligomer formation is a…”
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Modeling Transient Changes in Circadian Rhythms by Zhao, Ziyu, Hwangbo, Dae-Sung, Saurabh, Sumit, Rosensweig, Clark, Allada, Ravi, Kath, William L, Braun, Rosemary

“…The circadian clock can adapt itself to external cues, but the molecular mechanisms and regulatory networks governing circadian oscillations' transient…”
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Monoclonal antibody successes in the clinic : Antibody engineering and manufacture by REICHERT, Janice M, ROSENSWEIG, Clark J, FADEN, Laura B, DEWITZ, Matthew C

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Grape-Derived Polyphenolics Prevent A{beta} Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease by Wang, Jun, Ho, Lap, Zhao, Wei, Ono, Kenjiro, Rosensweig, Clark, Chen, Linghong, Humala, Nelson, Teplow, David B, Pasinetti, Giulio M

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Application of photochemical cross-linking to the study of oligomerization of amyloidogenic proteins by Lopes, Dahabada H J, Sinha, Sharmistha, Rosensweig, Clark, Bitan, Gal

“…Assembly of amyloidogenic proteins into toxic oligomers and fibrils is an important pathogenic feature of over 30 amyloid-related diseases. Understanding the…”
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Grape-derived polyphenolics prevent Abeta oligomerization and attenuate cognitive deterioration in a mouse model of Alzheimer's disease by Wang, Jun, Ho, Lap, Zhao, Wei, Ono, Kenjiro, Rosensweig, Clark, Chen, Linghong, Humala, Nelson, Teplow, David B, Pasinetti, Giulio M

“…Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive impairments in memory and cognition. Extracellular accumulation of…”
Get full text