Search Results - "Rosenspire, Allen J."

Editorial: The Role of the Environment in Autoimmunity by Pestka, James J, Pollard, K Michael, Rosenspire, Allen J

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At low levels, inorganic mercury interference with antigen signaling is associated with modifications to a panel of novel phosphoserine sites in B cell receptor pathway proteins by Guo, Chunna, Mattingly, Raymond R., Stemmer, Paul M., Rosenspire, Allen J.

“…Epidemiological studies indicate that human and animal exposure to environmental mercury (Hg) disrupts normal immune system function, but the molecular…”
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Naturally occurring autoimmune disease in (NZB X NZW) F1 mice is correlated with suppression of MZ B cell development due to aberrant B Cell Receptor (BCR) signaling, which is exacerbated by exposure to inorganic mercury by Gill, Randall F, Mathieu, Patricia A, Lash, Lawrence H, Rosenspire, Allen J

“…Autoimmune diseases are multifactorial and include environmental as well as genetic drivers. Although much progress has been made in understanding the nature…”
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Elements of the B Cell Signalosome are Differentially Affected by Mercury Intoxication by Gill, Randall F., Rosenspire, Allen J., McCabe, Michael J.

“…It has been suggested that environmental exposures to mercury contribute to autoimmune disease. Disruption of BCR signaling is associated with failure of…”
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Low and Nontoxic Inorganic Mercury Burdens Attenuate BCR-Mediated Signal Transduction by McCabe, Michael J., Laiosa, Michael D., Li, Li, Menard, Sherri L., Mattingly, Raymond R., Rosenspire, Allen J.

“…The ubiquitous environmental heavy metal contaminant mercury (Hg) is a potent immunomodulator that has been implicated as a factor contributing to autoimmune…”
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Cutting Edge: Fever-Associated Temperatures Enhance Neutrophil Responses to Lipopolysaccharide: A Potential Mechanism Involving Cell Metabolism by Rosenspire, Allen J, Kindzelskii, Andrei L, Petty, Howard R

“…Although much progress has been made in elucidating the mechanisms underlying the physiological regulation of fever, there is little understanding of the…”
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Anergic B Cells: Precarious On-Call Warriors at the Nexus of Autoimmunity and False-Flagged Pathogens by Rosenspire, Allen J, Chen, Kang

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Low level Hg2+ exposure modulates the B-cell cytoskeletal phosphoproteome by Carruthers, Nicholas J., Rosenspire, Allen J., Caruso, Joseph A., Stemmer, Paul M.

“…Exposure of Wehi-231 B-cells to Hg2+ for 5min resulted in concentration dependent changes in protein phosphorylations. Phosphorylation was quantified using…”
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A systems toxicology approach identifies Lyn as a key signaling phosphoprotein modulated by mercury in a B lymphocyte cell model by Caruso, Joseph A., Stemmer, Paul M., Dombkowski, Alan, Caruthers, Nicholas J., Gill, Randall, Rosenspire, Allen J.

“…Network and protein–protein interaction analyses of proteins undergoing Hg2+-induced phosphorylation and dephosphorylation in Hg2+-intoxicated mouse WEHI-231 B…”
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HLA Immune Function Genes in Autism by Torres, Anthony R., Westover, Jonna B., Rosenspire, Allen J.

“…The human leukocyte antigen (HLA) genes on chromosome 6 are instrumental in many innate and adaptive immune responses. The HLA genes/haplotypes can also be…”
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T-cell receptor signaling is mediated by transient Lck activity, which is inhibited by inorganic mercury by Ziemba, Stamatina E, Menard, Sherri L, McCabe, Michael J. Jr, Rosenspire, Allen J

“…Genetically susceptible rodents exposed to low nontoxic levels of inorganic mercury (Hg²⁺) develop idiosyncratic autoimmune disease associated with defective…”
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Real-Time Control of Neutrophil Metabolism by Very Weak Ultra-Low Frequency Pulsed Magnetic Fields by Rosenspire, Allen J., Kindzelskii, Andrei L., Simon, Bruce J., Petty, Howard R.

“…In adherent and motile neutrophils NAD(P)H concentration, flavoprotein redox potential, and production of reactive oxygen species and nitric oxide, are all…”
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Inorganic mercury dissociates preassembled Fas/CD95 receptor oligomers in T lymphocytes by Ziemba, Stamatina E., McCabe, Michael J., Rosenspire, Allen J.

“…Genetically susceptible rodents exposed to low burdens of inorganic mercury (Hg 2+) develop autoimmune disease. Previous studies have shown that low,…”
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Exposure to inorganic mercury in vivo attenuates extrinsic apoptotic signaling in Staphylococcal aureus enterotoxin B stimulated T-cells by Laiosa, Michael D., Eckles, Kevin G., Langdon, Margaret, Rosenspire, Allen J., McCabe, Michael J.

“…The heavy metal mercury (Hg) is known to have immunomodulatory properties affecting lymphocyte signal transduction, death receptor signaling and autoimmunity…”
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Inorganic Mercury Inhibits the Activation of LAT in T-Cell Receptor-Mediated Signal Transduction by Ziemba, Stamatina E., Mattingly, Raymond R., McCabe, Michael J., Rosenspire, Allen J.

“…Little is known as to the molecular mechanisms involved with mercury intoxication at very low levels. Although the mechanism is not known, animal studies have…”
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Gene expression influences on metal immunomodulation by Lynes, Michael A., Fontenot, Andrew P., Lawrence, David A., Rosenspire, Allen J., Pollard, K. Michael

“…Heavy metals in the environment originate from both human activities and natural processes. Exposure to these metals can result in important changes to immune…”
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Differential Screening and Mass Mapping of Proteins from Premalignant and Cancer Cell Lines Using Nonporous Reversed-Phase HPLC Coupled with Mass Spectrometric Analysis by Chong, Bathsheba E, Hamler, Rick L, Lubman, David M, Ethier, Stephen P, Rosenspire, Allen J, Miller, Fred R

“…Nonporous (NPS) RP-HPLC has been used to rapidly separate proteins from whole cell lysates of human breast cell lines. The nonporous separation involves the…”
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Inorganic mercury attenuates CD95-mediated apoptosis by interfering with formation of the death inducing signaling complex by McCabe, Michael J, Whitekus, Michael J, Hyun, Joogyung, Eckles, Kevin G, McCollum, Geniece, Rosenspire, Allen J

“…Inorganic mercury (Hg 2+) modulates several lymphocyte signaling pathways and has been implicated as an environmental factor linked to autoimmune disease. From…”
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Attenuation of CD95-induced apoptosis by inorganic mercury: caspase-3 is not a direct target of low levels of Hg2 by MCCABE, Michael J, ECKLES, Kevin G, LANGDON, Margaret, CLARKSON, Thomas W, WHITEKUS, Michael J, ROSENSPIRE, Allen J

“…Exposure to environmental mercury may be a factor that contributes to idiosyncratic autoimmune disease. Studies have demonstrated that inorganic, ionic mercury…”
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Protection Against CD95-Mediated Apoptosis by Inorganic Mercury in Jurkat T Cells by Whitekus, Michael J, Santini, Ronald P, Rosenspire, Allen J, McCabe, Michael J., Jr

“…Dysregulation of CD95/Fas-mediated apoptosis has been implicated as a contributing factor in autoimmune disorders. Animal studies clearly have established a…”
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