Search Results - "Rosenquist, R"

Antigen receptor stereotypy in chronic lymphocytic leukemia by Stamatopoulos, K, Agathangelidis, A, Rosenquist, R, Ghia, P

“…The discovery of almost identical or ‘stereotyped’ B-cell receptor immunoglobulins (BcR IG) among unrelated patients with chronic lymphocytic leukemia (CLL)…”
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ERIC recommendations for TP53 mutation analysis in chronic lymphocytic leukemia—update on methodological approaches and results interpretation by Malcikova, J., Tausch, E., Rossi, D., Sutton, L. A., Soussi, T., Zenz, T., Kater, A. P., Niemann, C. U., Gonzalez, D., Davi, F., Gonzalez Diaz, M., Moreno, C., Gaidano, G., Stamatopoulos, K., Rosenquist, R., Stilgenbauer, S., Ghia, P., Pospisilova, S.

“…In chronic lymphocytic leukemia (CLL), TP53 gene defects, due to deletion of the 17p13 locus and/or mutation(s) within the TP53 gene, are associated with…”
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Cell‐free tumour DNA testing for early detection of cancer – a potential future tool by Barbany, G., Arthur, C., Liedén, A., Nordenskjöld, M., Rosenquist, R., Tesi, B., Wallander, K., Tham, E.

“…In recent years, detection of cell‐free tumour DNA (ctDNA) or liquid biopsy has emerged as an attractive noninvasive methodology to detect cancer‐specific…”
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Immunoglobulin gene sequence analysis in chronic lymphocytic leukemia: updated ERIC recommendations by Rosenquist, R, Ghia, P, Hadzidimitriou, A, Sutton, L-A, Agathangelidis, A, Baliakas, P, Darzentas, N, Giudicelli, V, Lefranc, M-P, Langerak, A W, Belessi, C, Davi, F, Stamatopoulos, K

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Prognostic indices in chronic lymphocytic leukaemia: where do we stand how do we proceed? by Baliakas, P., Mattsson, M., Stamatopoulos, K., Rosenquist, R.

“…The remarkable clinical heterogeneity in chronic lymphocytic leukaemia (CLL) has highlighted the need for prognostic and predictive algorithms that can be…”
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Recurrent mutations refine prognosis in chronic lymphocytic leukemia by Baliakas, P, Hadzidimitriou, A, Sutton, L-A, Rossi, D, Minga, E, Villamor, N, Larrayoz, M, Kminkova, J, Agathangelidis, A, Davis, Z, Tausch, E, Stalika, E, Kantorova, B, Mansouri, L, Scarfò, L, Cortese, D, Navrkalova, V, Rose-Zerilli, M J J, Smedby, K E, Juliusson, G, Anagnostopoulos, A, Makris, A M, Navarro, A, Delgado, J, Oscier, D, Belessi, C, Stilgenbauer, S, Ghia, P, Pospisilova, S, Gaidano, G, Campo, E, Strefford, J C, Stamatopoulos, K, Rosenquist, R

“…Through the European Research Initiative on chronic lymphocytic leukemia (CLL) (ERIC), we screened 3490 patients with CLL for mutations within the NOTCH1 ( n…”
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Genetic landscape and deregulated pathways in B‐cell lymphoid malignancies by Rosenquist, R., Beà, S., Du, M.‐Q., Nadel, B., Pan‐Hammarström, Q.

“…With the introduction of next‐generation sequencing, the genetic landscape of the complex group of B‐cell lymphoid malignancies has rapidly been unravelled in…”
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Targeted next-generation sequencing in chronic lymphocytic leukemia: a high-throughput yet tailored approach will facilitate implementation in a clinical setting by Sutton, Lesley-Ann, Ljungström, Viktor, Mansouri, Larry, Young, Emma, Cortese, Diego, Navrkalova, Veronika, Malcikova, Jitka, Muggen, Alice F, Trbusek, Martin, Panagiotidis, Panagiotis, Davi, Frederic, Belessi, Chrysoula, Langerak, Anton W, Ghia, Paolo, Pospisilova, Sarka, Stamatopoulos, Kostas, Rosenquist, Richard

“…Next-generation sequencing has revealed novel recurrent mutations in chronic lymphocytic leukemia, particularly in patients with aggressive disease. Here, we…”
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Introduction to the symposium ‘Targeted therapy in B‐cell malignancies’ by Smedby, K. E., Rosenquist, R.

“…Content List ‐ Read more articles from the symposium: Targeted therapy in B‐cell malignancies…”
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Impact of TP53 mutation and 17p deletion in mantle cell lymphoma by Halldórsdóttir, A M, Lundin, A, Murray, F, Mansouri, L, Knuutila, S, Sundström, C, Laurell, A, Ehrencrona, H, Sander, B, Rosenquist, R

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Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia by Parker, H, Rose-Zerilli, M J J, Larrayoz, M, Clifford, R, Edelmann, J, Blakemore, S, Gibson, J, Wang, J, Ljungström, V, Wojdacz, T K, Chaplin, T, Roghanian, A, Davis, Z, Parker, A, Tausch, E, Ntoufa, S, Ramos, S, Robbe, P, Alsolami, R, Steele, A J, Packham, G, Rodríguez-Vicente, A E, Brown, L, McNicholl, F, Forconi, F, Pettitt, A, Hillmen, P, Dyer, M, Cragg, M S, Chelala, C, Oakes, C C, Rosenquist, R, Stamatopoulos, K, Stilgenbauer, S, Knight, S, Schuh, A, Oscier, D G, Strefford, J C

“…Histone methyltransferases (HMTs) are important epigenetic regulators of gene transcription and are disrupted at the genomic level in a spectrum of human…”
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ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemia by Ghia, P, Stamatopoulos, K, Belessi, C, Moreno, C, Stilgenbauer, S, Stevenson, F, Davi, F, Rosenquist, R

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On the way towards a ‘CLL prognostic index’: focus on TP53, BIRC3, SF3B1, NOTCH1 and MYD88 in a population-based cohort by Cortese, D, Sutton, L-A, Cahill, N, Smedby, K E, Geisler, C, Gunnarsson, R, Juliusson, G, Mansouri, L, Rosenquist, R

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EZH2 upregulates the PI3K/AKT pathway through IGF1R and MYC in clinically aggressive chronic lymphocytic leukaemia by Kosalai, Subazini Thankaswamy, Morsy, Mohammad Hamdy Abdelrazak, Papakonstantinou, Nikos, Mansouri, Larry, Stavroyianni, Niki, Kanduri, Chandrasekhar, Stamatopoulos, Kostas, Rosenquist, Richard, Kanduri, Meena

“…EZH2 is overexpressed in poor-prognostic chronic lymphocytic leukaemia (CLL) cases, acting as an oncogene; however, thus far, the EZH2 target genes in CLL have…”
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450K-array analysis of chronic lymphocytic leukemia cells reveals global DNA methylation to be relatively stable over time and similar in resting and proliferative compartments by Cahill, N, Bergh, A-C, Kanduri, M, Göransson-Kultima, H, Mansouri, L, Isaksson, A, Ryan, F, Smedby, K E, Juliusson, G, Sundström, C, Rosén, A, Rosenquist, R

“…In chronic lymphocytic leukemia (CLL), the microenvironment influences gene expression patterns; however, knowledge is limited regarding the extent to which…”
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NOTCH1 and SF3B1 mutations can be added to the hierarchical prognostic classification in chronic lymphocytic leukemia by Mansouri, L, Cahill, N, Gunnarsson, R, Smedby, K E, Tjönnfjord, E, Hjalgrim, H, Juliusson, G, Geisler, C, Rosenquist, R

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Transcriptome sequencing of archived lymphoma specimens is feasible and clinically relevant using exome capture technology by Skaftason, Aron, Qu, Ying, Abdulla, Maysaa, Nordlund, Jessica, Berglund, Mattias, Ednersson, Susanne Bram, Andersson, Per‐Ola, Enblad, Gunilla, Amini, Rose‐Marie, Rosenquist, Richard, Mansouri, Larry

“…Formalin‐fixed, paraffin‐embedded (FFPE) specimens are an underutilized resource in medical research, particularly in the setting of transcriptome sequencing,…”
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Cell‐of‐origin determined by both gene expression profiling and immunohistochemistry is the strongest predictor of survival in patients with diffuse large B‐cell lymphoma by Abdulla, Maysaa, Hollander, Peter, Pandzic, Tatjana, Mansouri, Larry, Ednersson, Susanne Bram, Andersson, Per‐Ola, Hultdin, Magnus, Fors, Maja, Erlanson, Martin, Degerman, Sofie, Petersen, Helga Munch, Asmar, Fazila, Grønbæk, Kirsten, Enblad, Gunilla, Cavelier, Lucia, Rosenquist, Richard, Amini, Rose‐Marie

“…The tumor cells in diffuse large B‐cell lymphomas (DLBCL) are considered to originate from germinal center derived B‐cells (GCB) or activated B‐cells (ABC)…”
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Clinical impact of recurrently mutated genes on lymphoma diagnostics: state-of-the-art and beyond by Rosenquist, Richard, Rosenwald, Andreas, Du, Ming-Qing, Gaidano, Gianluca, Groenen, Patricia, Wotherspoon, Andrew, Ghia, Paolo, Gaulard, Philippe, Campo, Elias, Stamatopoulos, Kostas

“…Similar to the inherent clinical heterogeneity of most, if not all, lymphoma entities, the genetic landscape of these tumors is markedly complex in the…”
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Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2 by Strefford, J C, Sutton, L-A, Baliakas, P, Agathangelidis, A, Malčíková, J, Plevova, K, Scarfó, L, Davis, Z, Stalika, E, Cortese, D, Cahill, N, Pedersen, L B, di Celle, P F, Tzenou, T, Geisler, C, Panagiotidis, P, Langerak, A W, Chiorazzi, N, Pospisilova, S, Oscier, D, Davi, F, Belessi, C, Mansouri, L, Ghia, P, Stamatopoulos, K, Rosenquist, R

“…Recent studies have revealed recurrent mutations of the NOTCH1 , SF3B1 and BIRC3 genes in chronic lymphocytic leukemia (CLL), especially among aggressive,…”
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