Search Results - "Rosengren, R."

Mechanisms of suppression of cell growth by dual inhibition of ALK and MEK in ALK-positive non-small cell lung cancer by Shrestha, N., Nimick, M., Dass, P., Rosengren, R. J., Ashton, J. C.

“…Anaplastic lymphoma kinase (ALK) rearrangement, a key oncogenic driver in a small subset of non-small cell lung cancers, confers sensitivity to ALK tyrosine…”
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The effect of metformin in EML4-ALK+ lung cancer alone and in combination with crizotinib in cell and rodent models by Bland, A.R., Shrestha, N., Bower, R.L., Rosengren, R.J., Ashton, J.C.

“…[Display omitted] Cell based studies have suggested that the diabetes drug metformin may combine with the anaplastic lymphoma kinase receptor (ALK) inhibitor…”
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Inhibition of Mitogen-Activated Protein Kinase Kinase Alone and in Combination with Anaplastic Lymphoma Kinase (ALK) Inhibition Suppresses Tumor Growth in a Mouse Model of ALK-Positive Lung Cancer by Shrestha, N., Bland, A.R., Bower, R.L., Rosengren, R.J., Ashton, J.C.

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Physical activity and quality of life in older adults: influence of health status and self-efficacy by McAuley, Edward, Konopack, James F, Motl, Robert W, Morris, Katherine S, Doerksen, Shawna E, Rosengren, Karl R

“…Physical activity has been positively linked to quality of life (QOL) in older adults. Measures of health status and global well-being represent common methods…”
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A new role for tamoxifen in oestrogen receptor-negative breast cancer when it is combined with epigallocatechin gallate by Scandlyn, M J, Stuart, E C, Somers-Edgar, T J, Menzies, A R, Rosengren, R J

“…We have previously shown that tamoxifen+epigallocatechin gallate (EGCG) is synergistically cytotoxic towards oestrogen receptor (ER)-negative breast cancer…”
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A laboratory course for teaching laboratory techniques, experimental design, statistical analysis, and peer review process to undergraduate science students by Gliddon, C. M., J. Rosengren, R.

“…This article describes a 13‐week laboratory course called Human Toxicology taught at the University of Otago, New Zealand. This course used a guided inquiry…”
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Tamoxifen and epigallocatechin gallate are synergistically cytotoxic to MDA-MB-231 human breast cancer cells by Chisholm, K, Bray, B. J, Rosengren, R. J

“…High concentrations of specific catechins [epigallocatechin gallate (EGCG), epigallocatechin (EGC) and epicatechin gallate (ECG)] inhibit the proliferation of…”
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Pathways from Physical Activity to Quality of Life in Older Women by McAuley, Edward, Doerksen, Shawna E., Morris, Katherine S., Motl, Robert W., Hu, Liang, Wójcicki, Thomas R., White, Siobhan M., Rosengren, Karl R.

“…Background In spite of consistent evidence to suggest that being more physically active is associated with enhanced quality of life (QOL), there have been…”
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Estrogen Receptor-Mediated Actions of Polyphenolic Catechins in Vivo and in Vitro by Goodin, M. G., Fertuck, K. C., Zacharewski, T. R., Rosengren, R. J.

“…Recent investigations have demonstrated that polyphenolic catechins inhibit breast cancer cell proliferation and tumor growth. However, the ER-mediated effects…”
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5085 POSTER New Curcumin Analogue RL-66 Has Promising Anti-breast Cancer and Antiangiogenic Activity by Yadav, B, Taurin, S, Larsen, L, Rosengren, R

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Sex- and strain-dependent effects of epigallocatechin gallate (EGCG) and epicatechin gallate (ECG) in the mouse by Goodin, M.G., Bray, B.J., Rosengren, R.J.

“…We have previously demonstrated that 50 mg/kg of epigallocatechin gallate (EGCG) is hepatotoxic to female Swiss Webster mice, while lower doses of EGCG and…”
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Deer velvet supplementation decreases the grade and metastasis of azoxymethane-induced colon cancer in the male rat by Fraser, A., Haines, S.R., Stuart, E.C., Scandlyn, M.J., Alexander, A., Somers-Edgar, T.J., Rosengren, R.J.

“…Since deer velvet (DV) extract promotes angiogenesis, its ability to modulate the growth and invasiveness of colon tumours was investigated. Male Wistar rats…”
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St. John's Wort Extract Induces CYP3A and CYP2E1 in the Swiss Webster Mouse by Bray, B. J., Perry, N. B., Menkes, D. B., Rosengren, R. J.

“…This investigation was designed to determine the ability of St. John's wort (SJW), a readily available antidepressant, to induce various hepatic drug…”
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Retinol Potentiates Acetaminophen-Induced Hepatotoxicity in the Mouse: Mechanistic Studies by Bray, B.J., Rosengren, R.J.

“…This study was designed to elucidate the mechanism of retinol's potentiation of acetaminophen-induced hepatotoxicity. To accomplish this, the major…”
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Acetaminophen elicits anti-estrogenic but not estrogenic responses in the immature mouse by Patel, R, Rosengren, R.J

“…Acetaminophen is a widely used analgesic, which has exhibited evidence of estrogenic activity in estrogen-receptor positive human breast cancer cells. However,…”
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Epigallocatechin Gallate Modulates CYP450 Isoforms in the Female Swiss-Webster Mouse by Goodin, Mette G., Rosengren, Rhonda J.

“…This study was designed to determine the effect of the in vivo administration of epigallocatechin gallate (EGCG) and epicatechin gallate (ECG) on enzymes…”
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The effect of retinol on hepatic and renal drug-metabolising enzymes by Bray, B.J, Goodin, M.G, Inder, R.E, Rosengren, R.J

“…Retinol pretreatment (75 mg/kg/day, 4 days) potentiated paracetamol-induced hepatotoxicity in BALB/c mice (alanine aminotransferase (ALT) activity; 2510 ± 602…”
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Short term treatment with St. John's wort, hypericin or hyperforin fails to induce CYP450 isoforms in the Swiss Webster mouse by Bray, B.J., Brennan, N.J., Perry, N.B., Menkes, D.B., Rosengren, R.J.

“…This investigation was designed to determine whether St. John's wort (SJW)(435 mg/kg/d), a readily available antidepressant, or its purported active…”
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Role of cytochrome P4502E1 in retinol's attenuation of carbon tetrachloride-induced hepatotoxicity in the swiss Webster mouse by INDER, R. E, BRAY, B. J, SIPES, I. G, ROSENGREN, R. J

“…In the mouse, retinol administration attenuates carbon tetrachloride (CCl4)-induced hepatic injury. We have investigated the role of cytochrome P4502E1…”
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Methylphenidate inhibits cytochrome P450 in the Swiss Webster mouse by Le Nedelec, M J, Rosengren, R J

“…Drug interactions have previously been reported following the co-administration of methylphenidate (MPH) and drugs metabolized by the cytochrome P450 (CYP450)…”
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