Search Results - "Rosengren, A. H."

Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes by Axelsson, A. S., Mahdi, T., Nenonen, H. A., Singh, T., Hänzelmann, S., Wendt, A., Bagge, A., Reinbothe, T. M., Millstein, J., Yang, X., Zhang, B., Gusmao, E. G., Shu, L., Szabat, M., Tang, Y., Wang, J., Salö, S., Eliasson, L., Artner, I., Fex, M., Johnson, J. D., Wollheim, C. B., Derry, J.M.J., Mecham, B., Spégel, P., Mulder, H., Costa, I.G., Zhang, E., Rosengren, A. H.

“…Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin secretion, but the mechanisms underlying insulin secretion failure are not…”
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Anaplerosis via pyruvate carboxylase is required for the fuel-induced rise in the ATP:ADP ratio in rat pancreatic islets by FRANSSON, U, ROSENGREN, A. H, SCHUIT, F. C, RENSTRÖM, E, MULDER, H

“…The molecular mechanisms of insulin release are only partially known. Among putative factors for coupling glucose metabolism to insulin secretion, anaplerosis…”
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Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes by Rosengren, Anders H, Jokubka, Ramunas, Tojjar, Damon, Granhall, Charlotte, Hansson, Ola, Li, Dai-Qing, Nagaraj, Vini, Reinbothe, Thomas M, Tuncel, Jonatan, Eliasson, Lena, Groop, Leif, Rorsman, Patrik, Salehi, Albert, Lyssenko, Valeriya, Luthman, Holger, Renström, Erik

“…Several common genetic variations have been associated with type 2 diabetes, but the exact disease mechanisms are still poorly elucidated. Using congenic…”
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Increased Expression of the Diabetes Gene SOX4 Reduces Insulin Secretion by Impaired Fusion Pore Expansion by Collins, Stephan C, Do, Hyun Woong, Hastoy, Benoit, Hugill, Alison, Adam, Julie, Chibalina, Margarita V, Galvanovskis, Juris, Godazgar, Mahdieh, Lee, Sheena, Goldsworthy, Michelle, Salehi, Albert, Tarasov, Andrei I, Rosengren, Anders H, Cox, Roger, Rorsman, Patrik

“…The transcription factor Sox4 has been proposed to underlie the increased type 2 diabetes risk linked to an intronic single nucleotide polymorphism in CDKAL1…”
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Clustering of diabetes into novel subgroups provides improved prediction of outcome by Ahlqvist, E., Karajamaki, A., Martinell, Mats, Storm, P., Dorkhan, M., Vikman, P., Prasad, R. B., Aly, D. Mansour, Shaat, N., Lindholm, E., Tuomi, T., Rosengren, A. H., Groop, L.

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Effect of self-managed lifestyle treatment on glycemic control in patients with type 2 diabetes by Dwibedi, Chinmay, Mellergård, Emelia, Gyllensten, Amaru Cuba, Nilsson, Kristoffer, Axelsson, Annika S., Bäckman, Malin, Sahlgren, Magnus, Friend, Stephen H., Persson, Sofie, Franzén, Stefan, Abrahamsson, Birgitta, Carlsson, Katarina Steen, Rosengren, Anders H.

“…The lack of effective, scalable solutions for lifestyle treatment is a global clinical problem, causing severe morbidity and mortality. We developed a method…”
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Bone marrow transplantation stimulates pancreatic β−cell replication after tissue damage by Rosengren, Andres H., Taneera, Jalal, Rymo, Simin, Renström, Erik

“…Bone marrow transplantation has been shown to normalize hyperglycemia but the mechanisms underlying pancreatic β-cell regeneration remain elusive. Here, we…”
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