Linking population-level and host-level models of influenza A virus

Input from the population-level models used in the RSA include viral load and 3 model parameters defining viral phenotypes (cell trophism, burst size, antiviral resistance), To date, we have developed a 2-dimensional RSA algorithm for a simplified model [2], where time to a damage threshold is expre...

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Bibliographic Details
Published in:	Journal of critical care Vol. 27; no. 3; p. e12
Main Authors:	Lukens, Sarah, DePasse, Jay V, Swigon, David, Miller, Danielle, Rosenfield, Roni, Ghedin, Elodie, Clermont, Gilles
Format:	Journal Article
Language:	English
Published:	Philadelphia Elsevier Inc 01-06-2012 Elsevier Limited
Subjects:	Critical Care Influenza Product design Studies
Online Access:	Get full text
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Summary:	Input from the population-level models used in the RSA include viral load and 3 model parameters defining viral phenotypes (cell trophism, burst size, antiviral resistance), To date, we have developed a 2-dimensional RSA algorithm for a simplified model [2], where time to a damage threshold is expressed as an algebraic function of initial pathogen load and pathogen growth rate.
ISSN:	0883-9441 1557-8615
DOI:	10.1016/j.jcrc.2012.01.034