Search Results - "Rosenfeldt, Hans M."

Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility by Hobson, John P., Rosenfeldt, Hans M., Barak, Larry S., Olivera, Ana, Poulton, Samantha, Caron, Marc G., Milstien, Sheldon, Spiegel, Sarah

“…EDG-1 is a heterotrimeric guanine nucleotide binding protein-coupled receptor (GPCR) for sphingosine-1-phosphate (SPP). Cell migration toward platelet-derived…”
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EDG‐1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration by Rosenfeldt, Hans M., Hobson, John P., Maceyka, Michael, Olivera, Ana, Nava, Victor E., Milstien, Sheldon, Spiegel, Sarah

“…ABSTRACT Sphingosine‐1‐phosphate (SPP), formed by sphingosine kinase, is the ligand for EDG‐1, a GPCR important for cell migration and vascular maturation…”
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The roles of sphingosine-1-phosphate in asthma by Jolly, Puneet S, Rosenfeldt, Hans M, Milstien, Sheldon, Spiegel, Sarah

“…Asthma is a complex condition in which exposure to environmental antigens induces inflammatory reactions in the airway characterized by activation of mast…”
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Sphingosine Kinase Type 1 Induces G12/13-mediated Stress Fiber Formation, yet Promotes Growth and Survival Independent of G Protein-coupled Receptors by Olivera, Ana, Rosenfeldt, Hans M., Bektas, Meryem, Wang, Fang, Ishii, Isao, Chun, Jerold, Milstien, Sheldon, Spiegel, Sarah

“…Sphingosine 1-phosphate (S1P) is the ligand for a family of specific G protein-coupled receptors (GPCRs) that regulate a wide variety of important cellular…”
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Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation by Liu, Y, Wada, R, Yamashita, T, Mi, Y, Deng, C X, Hobson, J P, Rosenfeldt, H M, Nava, V E, Chae, S S, Lee, M J, Liu, C H, Hla, T, Spiegel, S, Proia, R L

“…Sphingolipid signaling pathways have been implicated in many critical cellular events. Sphingosine-1-phosphate (SPP), a sphingolipid metabolite found in high…”
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Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion by Patel, Vyomesh, Rosenfeldt, Hans M., Lyons, Ruth, Servitja, Joan-Marc, Bustelo, Xosé R., Siroff, Mary, Gutkind, J.Silvio

“…The poor prognosis associated with head and neck squamous cell carcinoma (HNSCC) is primarily due to both local invasion and the regional and/or distant…”
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Sphingosine‐1‐phosphate stimulates contraction of human airway smooth muscle cells by Rosenfeldt, Hans M., Amrani, Yassine, Watterson, Kenneth R., Murthy, Karnam S., Panettieri, Reynold A., Spiegel, Sarah

“…The bioactive sphingolipid sphingosine‐1‐phosphate (S1P) that is increased in airways of asthmatic subjects markedly induced contraction of human airway smooth…”
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