Search Results - "Rosencrans, William M"

Dimeric Tubulin Modifies Mechanical Properties of Lipid Bilayer, as Probed Using Gramicidin A Channel by Rostovtseva, Tatiana K, Weinrich, Michael, Jacobs, Daniel, Rosencrans, William M, Bezrukov, Sergey M

“…Using the gramicidin A channel as a molecular probe, we show that tubulin binding to planar lipid membranes changes the channel kinetics-seen as an increase in…”
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Targeting the Multiple Physiologic Roles of VDAC With Steroids and Hydrophobic Drugs by Rostovtseva, Tatiana K, Queralt-Martín, María, Rosencrans, William M, Bezrukov, Sergey M

“…There is accumulating evidence that endogenous steroids and non-polar drugs are involved in the regulation of mitochondrial physiology. Many of these…”
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Single-molecule compaction of megabase-long chromatin molecules by multivalent cations by Zinchenko, Anatoly, Berezhnoy, Nikolay V, Wang, Sai, Rosencrans, William M, Korolev, Nikolay, van der Maarel, Johan R C, Nordenskiöld, Lars

“…Abstract To gain insight into the conformational properties and compaction of megabase-long chromatin molecules, we reconstituted chromatin from T4 phage DNA…”
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The p97 Inhibitor UPCDC-30245 Blocks Endo-Lysosomal Degradation by Wang, Feng, Li, Shan, Cheng, Kai-Wen, Rosencrans, William M, Chou, Tsui-Fen

“…The diverse modes of action of small molecule inhibitors provide versatile tools to investigate basic biology and develop therapeutics. However, it remains a…”
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VDAC regulation of mitochondrial calcium flux: From channel biophysics to disease by Rosencrans, William M., Rajendran, Megha, Bezrukov, Sergey M., Rostovtseva, Tatiana K.

“…[Display omitted] •VDAC plays an important role in mitochondrial calcium transport, regulation, and signaling.•VDAC is part of multi-protein complexes linking…”
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α-Synuclein emerges as a potent regulator of VDAC-facilitated calcium transport by Rosencrans, William M., Aguilella, Vicente M., Rostovtseva, Tatiana K., Bezrukov, Sergey M.

“…[Display omitted] •α-Synuclein, implicated in Parkinson’s disease, dynamically binds to VDAC pore and modifies its properties towards higher Ca2+…”
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TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1 by Le Guerroué, François, Bunker, Eric N., Rosencrans, William M., Nguyen, Jack T., Basar, Mohammed A., Werner, Achim, Chou, Tsui-Fen, Wang, Chunxin, Youle, Richard J.

“…Mitophagy is a form of selective autophagy that disposes of superfluous and potentially damage-inducing organelles in a tightly controlled manner. While the…”
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Restricting α-synuclein transport into mitochondria by inhibition of α-synuclein–VDAC complexation as a potential therapeutic target for Parkinson’s disease treatment by Rajendran, Megha, Queralt-Martín, María, Gurnev, Philip A., Rosencrans, William M., Rovini, Amandine, Jacobs, Daniel, Abrantes, Kaitlin, Hoogerheide, David P., Bezrukov, Sergey M., Rostovtseva, Tatiana K.

“…Involvement of alpha-synuclein (αSyn) in Parkinson’s disease (PD) is complicated and difficult to trace on cellular and molecular levels. Recently, we…”
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Defining the roles and regulation of the mitochondrial VDAC isoforms one molecule at a time by Rosencrans, William M., Queralt-Martin, Maria, Lessen, Henry J., Ghahari Larimi, Motahareh, Rajendran, Megha, Chou, Tsui-Fen, Mahalakshmi, Radhakrishnan, Sodt, Alexander J., Yu, Tsyr-Yan, Bezrukov, Sergey M., Rostovtseva, Tatiana K.

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Sulforaphane is Synergistic with CB‐5083 and Inhibits Colony Formation of CB‐5083‐Resistant HCT116 Cells by Wang, Feng, Li, Shan, Rosencrans, William M., Cheng, Kai‐Wen, Stott, Gordon M., Mroczkowski, Barbara, Chou, Tsui‐Fen

“…Human p97 is a potential drug target in oncology. Mutation‐driven drug resistance is an obstacle to the long‐term efficacy of targeted therapy. We found that…”
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Cells deficient for Krüppel-like factor 4 exhibit mitochondrial dysfunction and impaired mitophagy by Rosencrans, William M., Walsh, Zachary H., Houerbi, Nadia, Blum, Andrew, Belew, Mezmur, Liu, Changchang, Chernak, Brian, Brauer, Philip R., Trazo, Angel, Olson, Anna, Hagos, Engda

“…Krüppel-like factor 4 (Human Protein: KLF4; Human Gene: Klf4; Murine Protein: KLF4; Murine Gene: Klf4) is a zinc finger-containing transcription factor with…”
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αSynuclein Regulates Mitochondrial Calcium Transport through the Voltage Dependent Anion Channel by Rosencrans, William M., Aguilella, Vicente M., Rostovtseva, Tatiana K., Bezrukov, Sergey M.

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Abstract 1833: KLF4 regulates metabolic homeostasis in response to energy stress by Rosencrans, William M., Walsh, Zachary H., Blum, Andrew C., Hagos, Engda G.

“…Abstract Krüppel-like factor 4 (KLF4) is a zinc finger-containing transcription factor with diverse regulatory functions in cellular growth, proliferation,…”
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Sulforaphane is Synergistic with CB‐5083and Inhibits Colony Formation of CB‐5083‐Resistant HCT116 Cells by Wang, Feng, Li, Shan, Rosencrans, William M, Kai‐Wen Cheng, Stott, Gordon M, Mroczkowski, Barbara, Tsui‐Fen Chou

“…Human p97 is a potential drug target in oncology. Mutation‐driven drug resistance is an obstacle to the long‐term efficacy of targeted therapy. We found that…”
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Mechanism of Alpha-Synuclein Translocation into Mitochondria by Rajendran, Megha, Strub, Marie-Paule, Queralt-Martin, Maria, Rosencrans, William M., Bezrukov, Sergey M., Rostovtseva, Tatiana K.

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Effect of Steroids on Mitochondrial Metabolite Channel Function and Lipid Membrane Properties by Rosencrans, William M., Queralt-Martin, Maria, Rovini, Amandine, Gurnev, Phillip A., Bezrukov, Sergey M., Rostovtseva, Tatiana K.

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Dynamic Plasticity of Mitochondrial VDAC2 Revealed by Single-Molecule Electrophysiology by Rosencrans, William M., Queralt-Martin, Maria, Hoogerheide, David P., Gurnev, Philip A., Yu, Tsyr-Yan, Mahalakshmi, Radhakrishnan, Bezrukov, Sergey M., Rostovtseva, Tatiana K.

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Stretch and Dynamics of Single Chromatin Molecules Confined in Nanofluidic Channels by Rosencrans, William M., Liu, Fan, Berezhnoy, Nikolay V., Zinchenko, Anatoly, Nordenskiöld, Lars, van der Maarel, Johan R.C.

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Defining the roles and regulation of the mitochondrial VDAC isoforms one molecule at a time by Rosencrans, William M, Queralt-Martin, Maria, Lessen, Henry J, Larimi, Motahareh Ghahari, Rajendran, Megha, Chou, Tsui-Fen, Mahalakshmi, Radhakrishnan, Sodt, Alexander J, Yu, Tsyr-Yan, Bezrukov, Sergey M, Rostovtseva, Tatiana K

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