Search Results - "Rosenblatt, Kevin"

Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule by Hu, Ming Chang, Shi, Mingjun, Zhang, Jianning, Pastor, Johanne, Nakatani, Teruyo, Lanske, Beate, Razzaque, M. Shawkat, Rosenblatt, Kevin P, Baum, Michel G, Kuro-o, Makoto, Moe, Orson W

“…Klotho has profound effects on phosphate metabolism, but the mechanisms of how Klotho affects phosphate homeostasis is unknown. We detected Klotho in the…”
Get full text

Klotho Protects Dopaminergic Neuron Oxidant-Induced Degeneration by Modulating ASK1 and p38 MAPK Signaling Pathways by Brobey, Reynolds K, German, Dwight, Sonsalla, Patricia K, Gurnani, Prem, Pastor, Johanne, Hsieh, C-C, Papaconstantinou, John, Foster, Philip P, Kuro-o, Makoto, Rosenblatt, Kevin P

“…Klotho transgenic mice exhibit resistance to oxidative stress as measured by their urinal levels of 8-hydroxy-2-deoxyguanosine, albeit this anti-oxidant…”
Get full text

Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1 by Cha, Seung-Kuy, Ortega, Bernardo, Kurosu, Hiroshi, Rosenblatt, Kevin P, Kuro-o, Makoto, Huang, Chou-Long

“…Klotho is a mammalian senescence-suppression protein that has homology with glycosidases. The extracellular domain of Klotho is secreted into urine and blood…”
Get full text

Klotho Depletion Contributes to Increased Inflammation in Kidney of the db/db Mouse Model of Diabetes via RelA (Serine)536 Phosphorylation by YANHUA ZHAO, BANERJEE, Srijita, DEY, Nilay, LEJEUNE, Wanda S, SARKAR, Partha S, BROBEY, Reynolds, ROSENBLATT, Kevin P, TILTON, Ronald G, CHOUDHARY, Sanjeev

“…Klotho is an antiaging hormone present in the kidney that extends the lifespan, regulates kidney function, and modulates cellular responses to oxidative…”
Get full text

βKlotho is required for metabolic activity of fibroblast growth factor 21 by Ogawa, Yasushi, Kurosu, Hiroshi, Yamamoto, Masaya, Nandi, Animesh, Rosenblatt, Kevin P, Goetz, Regina, Eliseenkova, Anna V, Mohammadi, Moosa, Kuro-o, Makoto

“…Fibroblast growth factor 21 (FGF21) is a liver-derived endocrine factor that stimulates glucose uptake in adipocytes. Here, we show that FGF21 activity depends…”
Get full text

Klotho depletion contributes to increased inflammation in Kidney of the db/db mouse model of diabetes via RelA [.sup.536] phosphorylation by Zhao, Yanhua, Banerjee, Srijita, Dey, Nilay, LeJeune, Wanda S, Sarkar, Partha S, Brobey, Reynolds, Rosenblatt, Kevin P, Tilton, Ronald G, Choudhary, Sanjeev

“…OBJECTIVE--Klotho is an anti-aging hormone present in the kidney that extends the lifespan, regulates kidney function, and modulates cellular responses to…”
Get full text

Regulation of Fibroblast Growth Factor-23 Signaling by Klotho by Kurosu, Hiroshi, Ogawa, Yasushi, Miyoshi, Masayoshi, Yamamoto, Masaya, Nandi, Animesh, Rosenblatt, Kevin P., Baum, Michel G., Schiavi, Susan, Hu, Ming-Chang, Moe, Orson W., Kuro-o, Makoto

“…The aging suppressor gene Klotho encodes a single-pass transmembrane protein. Klotho-deficient mice exhibit a variety of aging-like phenotypes, many of which…”
Get full text

Circulating microparticle proteins obtained in the late first trimester predict spontaneous preterm birth at less than 35 weeks’ gestation: a panel validation with specific characterization by parity by McElrath, Thomas F., Cantonwine, David E., Jeyabalan, Arun, Doss, Robert C., Page, Gail, Roberts, James M., Brohman, Brian, Zhang, Zhen, Rosenblatt, Kevin P.

“…We have previously shown that protein biomarkers associated with circulating microparticles proteins (CMPs) obtained at the end of the first trimester may…”
Get full text

Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice by Voelkl, Jakob, Alesutan, Ioana, Leibrock, Christina B, Quintanilla-Martinez, Leticia, Kuhn, Volker, Feger, Martina, Mia, Sobuj, Ahmed, Mohamed S E, Rosenblatt, Kevin P, Kuro-O, Makoto, Lang, Florian

“…Klotho is a potent regulator of 1,25-hydroxyvitamin D3 [1,25(OH)2D3] formation and calcium-phosphate metabolism. Klotho-hypomorphic mice (kl/kl mice) suffer…”
Get full text

Suppression of Aging in Mice by the Hormone Klotho by Kurosu, Hiroshi, Yamamoto, Masaya, Clark, Jeremy D, Pastor, Johanne V, Nandi, Animesh, Gurnani, Prem, McGuinness, Owen P, Chikuda, Hirotaka, Yamaguchi, Masayuki, Kawaguchi, Hiroshi, Shimomura, Iichiro, Takayama, Yoshiharu, Herz, Joachim, Kahn, C. Ronald, Rosenblatt, Kevin P, Kuro-o, Makoto

“…A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-sensitive traits. Here, we show that overexpression of Klotho in mice…”
Get full text

Exercise-induced cognitive plasticity, implications for mild cognitive impairment and Alzheimer's disease by Foster, Philip P, Rosenblatt, Kevin P, Kuljiš, Rodrigo O

“…Lifestyle factors such as intellectual stimulation, cognitive and social engagement, nutrition, and various types of exercise appear to reduce the risk for…”
Get full text

Klotho Regulates 14-3-3ζ Monomerization and Binding to the ASK1 Signaling Complex in Response to Oxidative Stress by Brobey, Reynolds K, Dheghani, Mehdi, Foster, Philip P, Kuro-O, Makoto, Rosenblatt, Kevin P

“…The reactive oxygen species (ROS)-sensitive apoptosis signal-regulating kinase 1 (ASK1) signaling complex is a key regulator of p38 MAPK activity, a major…”
Get full text

Circulating microparticle proteins predict pregnancies complicated by placenta accreta spectrum by Yu, Hope Y., Gumusoglu, Serena B., Cantonwine, David E., Carusi, Daniela A., Gurnani, Prem, Schickling, Brandon, Doss, Robert C., Santillan, Mark K., Rosenblatt, Kevin P., McElrath, Thomas F.

“…Placenta accreta spectrum (PAS) is characterized by abnormal attachment of the placenta to the uterus, and attempts at placental delivery can lead to…”
Get full text

A multisite study to develop and validate first trimester, circulating microparticle biomarkers for tiered risk stratification of spontaneous preterm birth in nulliparas by Rosenblatt, Kevin P., Zhang, Zhen, Doss, Robert, Gurnani, Prem P., Grobman, William A., Silver, Robert M., Parry, Samuel, Reddy, Uma M., Cao, Sha, Haas, David M.

“…Despite much research, advances in early prediction of spontaneous preterm birth (sPTB) has been slow. The evolving field of circulating microparticle (CMP)…”
Get full text

Regulation of Oxidative Stress by the Anti-aging Hormone Klotho by Yamamoto, Masaya, Clark, Jeremy D., Pastor, Johanne V., Gurnani, Prem, Nandi, Animesh, Kurosu, Hiroshi, Miyoshi, Masayoshi, Ogawa, Yasushi, Castrillon, Diego H., Rosenblatt, Kevin P., Kuro-o, Makoto

“…klotho is an aging suppressor gene and extends life span when overexpressed in mice. Klotho protein was recently demonstrated to function as a hormone that…”
Get full text

Performance evaluation of a SARS-CoV-2 and influenza A/B combo rapid antigen test by Rosenblatt, Kevin P, Romeu, Hugo, Romeu, Camille, Granger, Elder

“…The global COVID-19 pandemic and seasonal influenza outbreaks have drawn attention to the critical need for accurate and efficient diagnostic tools. The…”
Get full text

Long-term alterations in maternal plasma proteome after sFlt1–induced preeclampsia in mice by Bytautiene, Egle, MD, PhD, Bulayeva, Nataliya, PhD, Bhat, Geeta, MS, Li, Li, MS, Rosenblatt, Kevin P., MD, PhD, Saade, George R., MD

“…Objective Preeclampsia is associated with long-term adverse maternal health, such as cardiovascular and metabolic diseases. The objective of this study was to…”
Get full text

Evaluation of proteomic biomarkers associated with circulating microparticles as an effective means to stratify the risk of spontaneous preterm birth by Cantonwine, David E., PhD, MPH, Zhang, Zhen, PhD, Rosenblatt, Kevin, MD, PhD, Goudy, Kevin S., PhD, Doss, Robert C., PhD, Ezrin, Alan M., PhD, Page, Gail, Ms, Brohman, Brian, Mr, Mcelrath, Thomas F., MD, PhD

“…Abstract Background The analysis of circulating microparticles in pregnancy is of revolutionary potential as it represents an in vivo ‘biopsy’ of active…”
Get full text

The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging by Hsieh, C-C, Kuro-o, Makoto, Rosenblatt, Kevin P, Brobey, Reynolds, Papaconstantinou, John

“…Reactive oxygen species (ROS) and elevated levels of p38 MAPK activity accelerate physiological aging. This emphasizes the importance of understanding the…”
Get full text

Late first trimester circulating microparticle proteins predict the risk of preeclampsia < 35 weeks and suggest phenotypic differences among affected cases by McElrath, Thomas F., Cantonwine, David E., Gray, Kathryn J., Mirzakhani, Hooman, Doss, Robert C., Khaja, Najmuddin, Khalid, Malik, Page, Gail, Brohman, Brian, Zhang, Zhen, Sarracino, David, Rosenblatt, Kevin P.

“…We hypothesize that first trimester circulating micro particle (CMP) proteins will define preeclampsia risk while identifying clusters of disease subtypes…”
Get full text