Search Results - "Rosenberg, Alex"
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Toxoplasma gondii secreted effectors co-opt host repressor complexes to inhibit necroptosis
Published in Cell host & microbe (14-07-2021)“…Toxoplasma gondii translocates effector proteins into its host cell to subvert various host pathways. T. gondii effector TgIST blocks the transcription of…”
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Expression of the Long Non-Coding RNA HOTAIR Correlates with Disease Progression in Bladder Cancer and Is Contained in Bladder Cancer Patient Urinary Exosomes
Published in PloS one (22-01-2016)“…Exosomes are 30-150nM membrane-bound secreted vesicles that are readily isolated from biological fluids such as urine (UEs). Exosomes contain proteins, micro…”
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3
The Molecular Timeline of a Reviving Bacterial Spore
Published in Molecular cell (19-02-2015)“…The bacterial spore can rapidly convert from a dormant to a fully active cell. Here we study this remarkable cellular transition in Bacillus subtilis and…”
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Resection versus expectant management of small incidentally discovered nonfunctional pancreatic neuroendocrine tumors
Published in Surgery (2016)“…Background Sporadic, nonfunctional pancreatic neuroendocrine tumors (NF-PNETs) are diagnosed with increasing frequency. We compared the risk of tumor growth,…”
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A combination of four Toxoplasma gondii nuclear-targeted effectors protects against interferon gamma-driven human host cell death
Published in mBio (16-10-2024)“…In both mice and humans, Type II interferon gamma (IFNγ) is crucial for the regulation of ( ) infection, during acute or chronic phases. To thwart this…”
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Clinicians' experience of barriers and facilitators to care delivery of an extracorporeal cardiopulmonary resuscitation service for out-of-hospital cardiac arrest: a qualitative survey
Published in Scandinavian journal of trauma, resuscitation and emergency medicine (13-09-2024)“…Out-of-hospital cardiac arrest (OHCA) survival in the UK remains overall poor with fewer than 10% of patients surviving to hospital discharge. Extracorporeal…”
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7
Architecture and Characteristics of Bacterial Nanotubes
Published in Developmental cell (22-02-2016)“…Bacteria display an array of contact-dependent interaction systems that have evolved to facilitate direct cell-to-cell communication. We have previously…”
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Transcriptomic Biomarkers to Discriminate Bacterial from Nonbacterial Infection in Adults Hospitalized with Respiratory Illness
Published in Scientific reports (26-07-2017)“…Lower respiratory tract infection (LRTI) commonly causes hospitalization in adults. Because bacterial diagnostic tests are not accurate, antibiotics are…”
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Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling
Published in PloS one (14-04-2011)“…There is accumulating evidence that dysregulated JAK signaling occurs in a wide variety of cancer types. In particular, mutations in JAK2 can result in the…”
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10
Susceptibility of Toxoplasma gondii to autophagy in human cells relies on multiple interacting parasite loci
Published in mBio (16-01-2024)“…Autophagy is a process used by cells to recycle organelles and macromolecules and to eliminate intracellular pathogens. Previous studies have shown that some…”
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Early Developmental Program Shapes Colony Morphology in Bacteria
Published in Cell reports (Cambridge) (01-03-2016)“…When grown on a solid surface, bacteria form highly organized colonies, yet little is known about the earliest stages of colony establishment. Following…”
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Molecular Kinetics of Reviving Bacterial Spores
Published in Journal of Bacteriology (01-05-2013)“…Bacterial spores can remain dormant for years, yet they possess a remarkable potential to rapidly resume a vegetative life form. Here, we identified a distinct…”
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Variation in CD8 T cell IFNγ differentiation to strains of Toxoplasma gondii is characterized by small effect QTLs with contribution from ROP16
Published in Frontiers in cellular and infection microbiology (23-05-2023)“…induces a strong CD8 T cell response characterized by the secretion of IFNγ that promotes host survival during infection. The initiation of CD8 T cell IFNγ…”
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14
Dynamic expression of the translational machinery during Bacillus subtilis life cycle at a single cell level
Published in PloS one (25-07-2012)“…The ability of bacteria to responsively regulate the expression of translation components is crucial for rapid adaptation to fluctuating environments…”
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15
Mechanical life support algorithm developed by simulation for inpatient emergency management of recipients of implantable left ventricular assist devices
Published in Resuscitation plus (01-06-2022)“…Published guidance concerning emergency management of left ventricular assist device (LVAD) recipients is both limited and lacking in consensus which increases…”
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Competitive SWIFT cluster templates enhance detection of aging changes
Published in Cytometry. Part A (01-01-2016)“…Clustering‐based algorithms for automated analysis of flow cytometry datasets have achieved more efficient and objective analysis than manual processing…”
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Effect of Immunohistochemistry on Molecular Analysis of Tissue Samples: Implications for Microdissection Technologies
Published in The journal of histochemistry and cytochemistry (01-06-2011)“…Laser-based tissue microdissection is an important tool for the molecular evaluation of histological sections. The technology has continued to advance since…”
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18
Making mechanism interesting
Published in Synthese (Dordrecht) (01-01-2018)“…I note the multitude of ways in which, beginning with the classic paper by Machamer et al. (Philos Sei 67:1–25, 2000), the mechanists have qualify their…”
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Kussmaul’s Sign in Right Ventricular Dysfunction
Published in Circulation (New York, N.Y.) (30-01-2007)Get full text
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Can we make sense of subjective experience in metabolically situated cognitive processes?
Published in Biology & philosophy (06-04-2018)“…In “Mind, matter and metabolism,” Godfrey-Smith’s objective is to “develop a picture” in which, first, the basis of living activity in physical processes…”
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