Search Results - "Rosenbaum, M M"

High-resolution crystal structure of the human CB1 cannabinoid receptor by Shao, Zhenhua, Yin, Jie, Chapman, Karen, Grzemska, Magdalena, Clark, Lindsay, Wang, Junmei, Rosenbaum, Daniel M.

“…The authors report a 2.6 Å resolution crystal structure of the human CB1 cannabinoid receptor trapped in the inactive conformation and bound to the antagonist…”
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Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant by Yin, Jie, Mobarec, Juan Carlos, Kolb, Peter, Rosenbaum, Daniel M.

“…The orexin system regulates sleep and arousal in humans, with orexin receptor antagonists becoming promising therapeutics for insomnia; now, the X-ray crystal…”
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Adaptive thermogenesis in humans by Rosenbaum, M, Leibel, R L

“…The increasing prevalence of obesity and its comorbidities reflects the interaction of genes that favor the storage of excess energy as fat with an environment…”
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The structure and function of G-protein-coupled receptors by Rosenbaum, Daniel M, Rasmussen, Søren G. F, Kobilka, Brian K

“…G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great…”
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Crystal structure of the human sterol transporter ABCG5/ABCG8 by Lee, Jyh-Yeuan, Kinch, Lisa N., Borek, Dominika M., Wang, Jin, Wang, Junmei, Urbatsch, Ina L., Xie, Xiao-Song, Grishin, Nikolai V., Cohen, Jonathan C., Otwinowski, Zbyszek, Hobbs, Helen H., Rosenbaum, Daniel M.

“…The X-ray structure of human ABCG5/ABCG8 heterodimer in a nucleotide-free state, being the first atomic model of an ABC sterol transporter. Human ABCG5/ABCG8…”
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Periodontal Bacteria and Prediabetes Prevalence in ORIGINS by Demmer, R T, Jr, Jacobs, Singh, R, Zuk, A, Rosenbaum, M, Papapanou, P N, Desvarieux, M

“…Periodontitis and type 2 diabetes mellitus are known to be associated. The relationship between periodontal microbiota and early diabetes risk has not been…”
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Structure and dynamics of the M3 muscarinic acetylcholine receptor by Kruse, Andrew C., Hu, Jianxin, Pan, Albert C., Arlow, Daniel H., Rosenbaum, Daniel M., Rosemond, Erica, Green, Hillary F., Liu, Tong, Chae, Pil Seok, Dror, Ron O., Shaw, David E., Weis, William I., Wess, Jürgen, Kobilka, Brian K.

“…The X-ray crystal structure of the M3 muscarinic acetylcholine receptor bound to the bronchodilator drug tiotropium is reported; comparison of this structure…”
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Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes by Xiao, Peng, Yan, Wei, Gou, Lu, Zhong, Ya-Ni, Kong, Liangliang, Wu, Chao, Wen, Xin, Yuan, Yuan, Cao, Sheng, Qu, Changxiu, Yang, Xin, Yang, Chuan-Cheng, Xia, Anjie, Hu, Zhenquan, Zhang, Qianqian, He, Yong-Hao, Zhang, Dao-Lai, Zhang, Chao, Hou, Gui-Hua, Liu, Huanxiang, Zhu, Lizhe, Fu, Ping, Yang, Shengyong, Rosenbaum, Daniel M., Sun, Jin-Peng, Du, Yang, Zhang, Lei, Yu, Xiao, Shao, Zhenhua

“…Dopamine receptors, including D1- and D2-like receptors, are important therapeutic targets in a variety of neurological syndromes, as well as cardiovascular…”
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Valence biases in reinforcement learning shift across adolescence and modulate subsequent memory by Rosenbaum, Gail M, Grassie, Hannah L, Hartley, Catherine A

“…As individuals learn through trial and error, some are more influenced by good outcomes, while others weight bad outcomes more heavily. Such valence biases may…”
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Structure of a nanobody-stabilized active state of the β2 adrenoceptor by Rasmussen, Søren G. F., Choi, Hee-Jung, Fung, Juan Jose, Pardon, Els, Casarosa, Paola, Chae, Pil Seok, DeVree, Brian T., Rosenbaum, Daniel M., Thian, Foon Sun, Kobilka, Tong Sun, Schnapp, Andreas, Konetzki, Ingo, Sunahara, Roger K., Gellman, Samuel H., Pautsch, Alexander, Steyaert, Jan, Weis, William I., Kobilka, Brian K.

“…G protein coupled receptors (GPCRs) exhibit a spectrum of functional behaviours in response to natural and synthetic ligands. Recent crystal structures provide…”
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Structure-based development of a subtype-selective orexin 1 receptor antagonist by Hellmann, Jan, Drabek, Matthäus, Yin, Jie, Gunera, Jakub, Pröll, Theresa, Kraus, Frank, Langmead, Christopher J., Hübner, Harald, Weikert, Dorothee, Kolb, Peter, Rosenbaum, Daniel M., Gmeiner, Peter

“…Orexins are neuropeptides that activate the rhodopsin-like G proteincoupled receptors OX1R and OX2R. The orexin system plays an important role in the…”
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Structure and function of an irreversible agonist-β2 adrenoceptor complex by Rosenbaum, Daniel M., Zhang, Cheng, Lyons, Joseph A., Holl, Ralph, Aragao, David, Arlow, Daniel H., Rasmussen, Søren G. F., Choi, Hee-Jung, DeVree, Brian T., Sunahara, Roger K., Chae, Pil Seok, Gellman, Samuel H., Dror, Ron O., Shaw, David E., Weis, William I., Caffrey, Martin, Gmeiner, Peter, Kobilka, Brian K.

“…β-adrenergic receptor structures Two papers by Brian Kobilka and colleagues describe the X-ray crystal structure of the human β 2 adrenergic receptor (β 2 AR)…”
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Guidance of Spatial Attention by Incidental Learning and Endogenous Cuing by Jiang, Yuhong V, Swallow, Khena M, Rosenbaum, Gail M

“…Our visual system is highly sensitive to regularities in the environment. Locations that were important in one's previous experience are often prioritized…”
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High-Resolution Crystal Structure of an Engineered Human β₂-Adrenergic G Protein-Coupled Receptor by Cherezov, Vadim, Rosenbaum, Daniel M, Hanson, Michael A, Rasmussen, Søren G.F, Thian, Foon Sun, Kobilka, Tong Sun, Choi, Hee-Jung, Kuhn, Peter, Weis, William I, Kobilka, Brian K, Stevens, Raymond C

“…Heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors constitute the largest family of eukaryotic signal transduction proteins that…”
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On the use of Pichia pastoris for isotopic labeling of human GPCRs for NMR studies by Clark, Lindsay, Dikiy, Igor, Rosenbaum, Daniel M., Gardner, Kevin H.

“…NMR studies of human integral membrane proteins provide unique opportunities to probe structure and dynamics at specific locations and on multiple timescales,…”
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Do adolescents always take more risks than adults? A within-subjects developmental study of context effects on decision making and processing by Rosenbaum, Gail M, Venkatraman, Vinod, Steinberg, Laurence, Chein, Jason M

“…Adolescents take more risks than adults in the real world, but laboratory experiments do not consistently demonstrate this pattern. In the current study, we…”
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Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors by Yin, Jie, Babaoglu, Kerim, Brautigam, Chad A, Clark, Lindsay, Shao, Zhenhua, Scheuermann, Thomas H, Harrell, Charles M, Gotter, Anthony L, Roecker, Anthony J, Winrow, Christopher J, Renger, John J, Coleman, Paul J, Rosenbaum, Daniel M

“…Human orexin receptors (hOX 1 R and hOX 2 R) are GPCRs involved in sleep regulation. Structures of hOX 1 R bound to a selective antagonist or to a dual…”
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Pathways and mechanisms linking dietary components to cardiometabolic disease: thinking beyond calories by Stanhope, K. L., Goran, M. I., Bosy‐Westphal, A., King, J. C., Schmidt, L. A., Schwarz, J.‐M., Stice, E., Sylvetsky, A. C., Turnbaugh, P. J., Bray, G. A., Gardner, C. D., Havel, P. J., Malik, V., Mason, A. E., Ravussin, E., Rosenbaum, M., Welsh, J. A., Allister‐Price, C., Sigala, D. M., Greenwood, M. R. C., Astrup, A., Krauss, R. M.

“…Summary Calories from any food have the potential to increase risk for obesity and cardiometabolic disease because all calories can directly contribute to…”
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Accurate Multiplex Polony Sequencing of an Evolved Bacterial Genome by Shendure, Jay, Porreca, Gregory J, Reppas, Nikos B, Lin, Xiaoxia, McCutcheon, John P, Rosenbaum, Abraham M, Wang, Michael D, Zhang, Kun, Mitra, Robi D, Church, George M

“…We describe a DNA sequencing technology in which a commonly available, inexpensive epifluorescence microscope is converted to rapid nonelectrophoretic DNA…”
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The development of a survey to examine knowledge about and attitudes toward concussion in high-school students by Rosenbaum, Aaron M., Arnett, Peter A.

“…The development of a new measure of concussion knowledge and attitudes that is more comprehensive and psychometrically sound than previous measures is…”
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