Search Results - "Rosenbaum, Daniel M."

High-resolution crystal structure of the human CB1 cannabinoid receptor by Shao, Zhenhua, Yin, Jie, Chapman, Karen, Grzemska, Magdalena, Clark, Lindsay, Wang, Junmei, Rosenbaum, Daniel M.

“…The authors report a 2.6 Å resolution crystal structure of the human CB1 cannabinoid receptor trapped in the inactive conformation and bound to the antagonist…”
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Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant by Yin, Jie, Mobarec, Juan Carlos, Kolb, Peter, Rosenbaum, Daniel M.

“…The orexin system regulates sleep and arousal in humans, with orexin receptor antagonists becoming promising therapeutics for insomnia; now, the X-ray crystal…”
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The structure and function of G-protein-coupled receptors by Rosenbaum, Daniel M, Rasmussen, Søren G. F, Kobilka, Brian K

“…G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great…”
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Crystal structure of the human sterol transporter ABCG5/ABCG8 by Lee, Jyh-Yeuan, Kinch, Lisa N., Borek, Dominika M., Wang, Jin, Wang, Junmei, Urbatsch, Ina L., Xie, Xiao-Song, Grishin, Nikolai V., Cohen, Jonathan C., Otwinowski, Zbyszek, Hobbs, Helen H., Rosenbaum, Daniel M.

“…The X-ray structure of human ABCG5/ABCG8 heterodimer in a nucleotide-free state, being the first atomic model of an ABC sterol transporter. Human ABCG5/ABCG8…”
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Structure and dynamics of the M3 muscarinic acetylcholine receptor by Kruse, Andrew C., Hu, Jianxin, Pan, Albert C., Arlow, Daniel H., Rosenbaum, Daniel M., Rosemond, Erica, Green, Hillary F., Liu, Tong, Chae, Pil Seok, Dror, Ron O., Shaw, David E., Weis, William I., Wess, Jürgen, Kobilka, Brian K.

“…The X-ray crystal structure of the M3 muscarinic acetylcholine receptor bound to the bronchodilator drug tiotropium is reported; comparison of this structure…”
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Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes by Xiao, Peng, Yan, Wei, Gou, Lu, Zhong, Ya-Ni, Kong, Liangliang, Wu, Chao, Wen, Xin, Yuan, Yuan, Cao, Sheng, Qu, Changxiu, Yang, Xin, Yang, Chuan-Cheng, Xia, Anjie, Hu, Zhenquan, Zhang, Qianqian, He, Yong-Hao, Zhang, Dao-Lai, Zhang, Chao, Hou, Gui-Hua, Liu, Huanxiang, Zhu, Lizhe, Fu, Ping, Yang, Shengyong, Rosenbaum, Daniel M., Sun, Jin-Peng, Du, Yang, Zhang, Lei, Yu, Xiao, Shao, Zhenhua

“…Dopamine receptors, including D1- and D2-like receptors, are important therapeutic targets in a variety of neurological syndromes, as well as cardiovascular…”
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Structure of a nanobody-stabilized active state of the β2 adrenoceptor by Rasmussen, Søren G. F., Choi, Hee-Jung, Fung, Juan Jose, Pardon, Els, Casarosa, Paola, Chae, Pil Seok, DeVree, Brian T., Rosenbaum, Daniel M., Thian, Foon Sun, Kobilka, Tong Sun, Schnapp, Andreas, Konetzki, Ingo, Sunahara, Roger K., Gellman, Samuel H., Pautsch, Alexander, Steyaert, Jan, Weis, William I., Kobilka, Brian K.

“…G protein coupled receptors (GPCRs) exhibit a spectrum of functional behaviours in response to natural and synthetic ligands. Recent crystal structures provide…”
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Structure-based development of a subtype-selective orexin 1 receptor antagonist by Hellmann, Jan, Drabek, Matthäus, Yin, Jie, Gunera, Jakub, Pröll, Theresa, Kraus, Frank, Langmead, Christopher J., Hübner, Harald, Weikert, Dorothee, Kolb, Peter, Rosenbaum, Daniel M., Gmeiner, Peter

“…Orexins are neuropeptides that activate the rhodopsin-like G proteincoupled receptors OX1R and OX2R. The orexin system plays an important role in the…”
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Structure and function of an irreversible agonist-β2 adrenoceptor complex by Rosenbaum, Daniel M., Zhang, Cheng, Lyons, Joseph A., Holl, Ralph, Aragao, David, Arlow, Daniel H., Rasmussen, Søren G. F., Choi, Hee-Jung, DeVree, Brian T., Sunahara, Roger K., Chae, Pil Seok, Gellman, Samuel H., Dror, Ron O., Shaw, David E., Weis, William I., Caffrey, Martin, Gmeiner, Peter, Kobilka, Brian K.

“…β-adrenergic receptor structures Two papers by Brian Kobilka and colleagues describe the X-ray crystal structure of the human β 2 adrenergic receptor (β 2 AR)…”
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High-Resolution Crystal Structure of an Engineered Human β₂-Adrenergic G Protein-Coupled Receptor by Cherezov, Vadim, Rosenbaum, Daniel M, Hanson, Michael A, Rasmussen, Søren G.F, Thian, Foon Sun, Kobilka, Tong Sun, Choi, Hee-Jung, Kuhn, Peter, Weis, William I, Kobilka, Brian K, Stevens, Raymond C

“…Heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors constitute the largest family of eukaryotic signal transduction proteins that…”
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On the use of Pichia pastoris for isotopic labeling of human GPCRs for NMR studies by Clark, Lindsay, Dikiy, Igor, Rosenbaum, Daniel M., Gardner, Kevin H.

“…NMR studies of human integral membrane proteins provide unique opportunities to probe structure and dynamics at specific locations and on multiple timescales,…”
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Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors by Yin, Jie, Babaoglu, Kerim, Brautigam, Chad A, Clark, Lindsay, Shao, Zhenhua, Scheuermann, Thomas H, Harrell, Charles M, Gotter, Anthony L, Roecker, Anthony J, Winrow, Christopher J, Renger, John J, Coleman, Paul J, Rosenbaum, Daniel M

“…Human orexin receptors (hOX 1 R and hOX 2 R) are GPCRs involved in sleep regulation. Structures of hOX 1 R bound to a selective antagonist or to a dual…”
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Crystal structure of the human β2 adrenergic G-protein-coupled receptor by RASMUSSEN, Søren G. F, CHOI, Hee-Jung, SCHERTLER, Gebhard F. X, WEIS, William I, K OBILKA, Brian K, ROSENBAUM, Daniel M, TONG SUN KOBILKA, FOON SUN THIAN, EDWARDS, Patricia C, BURGHAMMER, Manfred, RATNALA, Venkata R. P, S ANISHVILI, Ruslan, F ISCHETTI, Robert F

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Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model by Rosenbaum, Daniel M., Degterev, Alexei, David, Joel, Rosenbaum, Pearl S., Roth, Steven, Grotta, James C., Cuny, Gregory D., Yuan, Junying, Savitz, Sean I.

“…Necroptosis is programmed necrosis triggered by death receptor signaling. We investigated whether necroptosis contributes to neuronal damage and functional…”
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Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor by Bokoch, Michael P., Zou, Yaozhong, Rasmussen, Søren G. F., Liu, Corey W., Nygaard, Rie, Rosenbaum, Daniel M., Fung, Juan José, Choi, Hee-Jung, Thian, Foon Sun, Kobilka, Tong Sun, Puglisi, Joseph D., Weis, William I., Pardo, Leonardo, Prosser, R. Scott, Mueller, Luciano, Kobilka, Brian K.

“…Ligand-specific changes in GPCRs G-protein-coupled receptors (GPCRs) mediate the majority of cellular responses to hormones and neurotransmitters, and these…”
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Molecular mechanism of the wake-promoting agent TAK-925 by Yin, Jie, Kang, Yanyong, McGrath, Aaron P., Chapman, Karen, Sjodt, Megan, Kimura, Eiji, Okabe, Atsutoshi, Koike, Tatsuki, Miyanohana, Yuhei, Shimizu, Yuji, Rallabandi, Rameshu, Lian, Peng, Bai, Xiaochen, Flinspach, Mack, De Brabander, Jef K., Rosenbaum, Daniel M.

“…The OX 2 orexin receptor (OX 2 R) is a highly expressed G protein-coupled receptor (GPCR) in the brain that regulates wakefulness and circadian rhythms in…”
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Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA by Suno, Ryoji, Kimura, Kanako Terakado, Nakane, Takanori, Yamashita, Keitaro, Wang, Junmei, Fujiwara, Takaaki, Yamanaka, Yasuaki, Im, Dohyun, Horita, Shoichiro, Tsujimoto, Hirokazu, Tawaramoto, Maki S., Hirokawa, Takatsugu, Nango, Eriko, Tono, Kensuke, Kameshima, Takashi, Hatsui, Takaki, Joti, Yasumasa, Yabashi, Makina, Shimamoto, Keiko, Yamamoto, Masaki, Rosenbaum, Daniel M., Iwata, So, Shimamura, Tatsuro, Kobayashi, Takuya

“…Orexin peptides in the brain regulate physiological functions such as the sleep-wake cycle, and are thus drug targets for the treatment of insomnia. Using…”
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Reply to: The G protein preference of orexin receptors is currently an unresolved issue by Yin, Jie, Kang, Yanyong, McGrath, Aaron P., Chapman, Karen, Sjodt, Megan, Kimura, Eiji, Okabe, Atsutoshi, Koike, Tatsuki, Miyanohana, Yuhei, Shimizu, Yuji, Rallabandi, Rameshu, Lian, Peng, Bai, Xiaochen, Flinspach, Mack, De Brabander, Jef K., Rosenbaum, Daniel M.

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The prolyl 4-hydroxylase inhibitor GSK360A decreases post-stroke brain injury and sensory, motor, and cognitive behavioral deficits by Zhou, Jin, Li, Jie, Rosenbaum, Daniel M, Zhuang, Jian, Poon, Carrie, Qin, Pu, Rivera, Katrina, Lepore, John, Willette, Robert N, Hu, Erding, Barone, Frank C

“…There is interest in pharmacologic preconditioning for end-organ protection by targeting the HIF system. This can be accomplished by inhibition of prolyl…”
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Ligand modulation of sidechain dynamics in a wild-type human GPCR by Clark, Lindsay D, Dikiy, Igor, Chapman, Karen, Rödström, Karin Ej, Aramini, James, LeVine, Michael V, Khelashvili, George, Rasmussen, Søren Gf, Gardner, Kevin H, Rosenbaum, Daniel M

“…GPCRs regulate all aspects of human physiology, and biophysical studies have deepened our understanding of GPCR conformational regulation by different ligands…”
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