The ultrastructure of the plasma-sprayed hydroxyapatite–bone interface predisposing to bone bonding

The ultrastructure of the plasma-sprayed hydroxyapatite–bone interface predisposing to bone bonding

The deposition of biological apatite and subsequent formation of bone on hydroxyapatite implants depends on the partial dissolution of the implant surface and the reprecipitation of carbonated apatite from the biological milieu. Previous investigations in vitro have shown that the degree of dissolut...

Full description

Saved in:
Bibliographic Details
Published in:Biomaterials Vol. 23; no. 3; pp. 725 - 733
Main Authors: Porter, A.E., Hobbs, L.W., Rosen, V.Benezra, Spector, M.
Format: Journal Article
Language:English
Published: Netherlands Elsevier Ltd 01-02-2002
Subjects:
Alloys - chemistry
Bone Substitutes - chemistry
Carbonated-apatite
Coated Materials, Biocompatible - chemistry
Collagen - chemistry
Crystallization
Durapatite - chemistry
Humans
Hydroxyapatite
Microscopy, Electron
Microscopy, Electron, Scanning
Mineralization
Plasma spraying
Prosthesis Design
Reprecipitation
Titanium
Carbonated-apatite
Hydroxyapatite
Reprecipitation
Plasma spraying
Mineralization
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The deposition of biological apatite and subsequent formation of bone on hydroxyapatite implants depends on the partial dissolution of the implant surface and the reprecipitation of carbonated apatite from the biological milieu. Previous investigations in vitro have shown that the degree of dissolution and reprecipitation decreases as the coating crystallinity increases. These findings prompted the current study of the effects of coating crystallinity on the mechanism of bone bonding. The process of mineralization of bone associated with a hydroxyapatite coating was compared to the normal process of ossification. Plasma-sprayed hydroxyapatite (PSHA) coated titanium alloy (6% Al–4% V) rods as received and annealed for 0.7 h at 600°C in air to increase the coating crystallinity were implanted in the proximal and distal femora and proximal tibiae of adult mongrel dogs for 3 h, 3 and 10 days. Bony sites containing the implant were prepared for ultramicrotomy and transmission electron microscopy using an anhydrous embedding procedure: fixation in ethylene glycol and embedment in Spurr's resin. The results demonstrated the precipitation of biological apatite crystallites on non-annealed PSHA coatings in vivo within 3 h of implantation. After 3 and 10 days there were differences in the ultrastructure of the mineral phase on the surfaces of non-annealed and annealed surfaces. Observations showed that there was little difference in the mechanism of mineralization of bone associated with HA-coated prostheses and the normal process of ossification.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0142-9612
1878-5905
DOI:10.1016/S0142-9612(01)00177-6