Search Results - "Rosen, Mitchell B"

Evaluation of perfluoroalkyl acid activity using primary mouse and human hepatocytes by Rosen, Mitchell B, Das, Kaberi P, Wood, Carmen R, Wolf, Cynthia J, Abbott, Barbara D, Lau, Christopher

“…Abstract While perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) have been studied at length, less is known about the biological activity of…”
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Gene Expression Profiling in Wild-Type and PPARα-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPARα-Independent Effects by Rosen, Mitchell B., Schmid, Judith R., Corton, J. Christopher, Zehr, Robert D., Das, Kaberi P., Abbott, Barbara D., Lau, Christopher

“…Perfluorooctane sulfonate (PFOS) is a perfluoroalkyl acid (PFAA) and a persistent environmental contaminant found in the tissues of humans and wildlife…”
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PPARα-independent transcriptional targets of perfluoroalkyl acids revealed by transcript profiling by Rosen, Mitchell B, Das, Kaberi P, Rooney, John, Abbott, Barbara, Lau, Christopher, Corton, J. Christopher

“…Abstract Perfluoroalkyl acids (PFAAs) are ubiquitous and persistent environmental contaminants. Compounds such as perfluoroocanoic acid (PFOA), perfluorooctane…”
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Developmental toxicity of perfluorononanoic acid in mice by Das, Kaberi P., Grey, Brian E., Rosen, Mitchell B., Wood, Carmen R., Tatum-Gibbs, Katoria R., Zehr, R. Daniel, Strynar, Mark J., Lindstrom, Andrew B., Lau, Christopher

“…•Similar to PFOA, PFNA caused neonatal mortality and growth deficits.•PFNA was more potent than PFOA, due in part to a longer half life.•PFNA increased liver…”
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Toxicogenomic Dissection of the Perfluorooctanoic Acid Transcript Profile in Mouse Liver: Evidence for the Involvement of Nuclear Receptors PPARα and CAR by Rosen, Mitchell B., Lee, Janice S., Ren, Hongzu, Vallanat, Beena, Liu, Jie, Waalkes, Michael P., Abbott, Barbara D., Lau, Christopher, Corton, J. Christopher

“…A number of perfluorinated alkyl acids including perfluorooctanoic acid (PFOA) elicit effects similar to peroxisome proliferator chemicals (PPC) in mouse and…”
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Does Exposure to Perfluoroalkyl Acids Present a Risk to Human Health? by Rosen, Mitchell B., Lau, Christopher, Corton, J. Christopher

“…The information in this document has been funded by the U.S. Environmental Protection Agency. It has been subjected to review by the National Health and…”
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Gene Expression Profiling in Wild-Type and PPAR-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPAR-Independent Effects by Rosen, Mitchell B., Schmid, Judith R., Corton, J. Christopher, Zehr, Robert D., Das, Kaberi P., Abbott, Barbara D., Lau, Christopher

“…Perfluorooctane sulfonate (PFOS) is a perfluoroalkyl acid (PFAA) and a persistent environmental contaminant found in the tissues of humans and wildlife…”
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Gene Profiling in the Livers of Wild-type and PPARα-Null Mice Exposed to Perfluorooctanoic Acid by Rosen, Mitchell B., Abbott, Barbara D., Wolf, Douglas C., Corton, J. Christopher, Wood, Carmen R., Schmid, Judith E., Das, Kaberi P., Zehr, Robert D., Blair, Eric T., Lau, Christopher

“…Health concerns have been raised because perfluorooctanoic acid (PFOA) is commonly found in the environment and can be detected in humans. In rodents, PFOA is…”
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Gene expression profiling in the lung and liver of PFOA-exposed mouse fetuses by Rosen, Mitchell B, Thibodeaux, Julie R, Wood, Carmen R, Zehr, Robert D, Schmid, Judith E, Lau, Christopher

“…Abstract Perfluorooctanoic acid (PFOA) is a stable perfluoroalkyl acid used to synthesize fluoropolymers during the manufacture of a wide variety of products…”
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Comparative Hepatic Effects of Perfluorooctanoic Acid and WY 14,643 in PPAR-α Knockout and Wild-type Mice by Wolf, Douglas C., Moore, Tanya, Abbott, Barbara D., Rosen, Mitchell B., Das, Kaberi P., Zehr, Robert D., Lindstrom, Andrew B., Strynar, Mark J., Lau, Christopher

“…Perfluorooctanoic acid (PFOA) is a chemical used in the production of fluoropolymers. Its persistence in the environment and presence in humans and wildlife…”
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Gene expression profiling in the liver and lung of perfluorooctane sulfonate-exposed mouse fetuses: Comparison to changes induced by exposure to perfluorooctanoic acid by Rosen, Mitchell B., Schmid, Judith E., Das, Kaberi P., Wood, Carmen R., Zehr, Robert D., Lau, Christopher

“…Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are environmental contaminants found in the tissues of humans and wildlife. They are…”
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ATP Binding Cassette Sub‐family Member 2 (ABCG2) and Xenobiotic Exposure During Early Mouse Embryonic Stem Cell Differentiation by Rosen, Mitchell B., Jeffay, Susan C., Nichols, Harriette P., Hoopes, Maria R., Hunter, E. Sidney

“…Background ATP binding cassette sub‐family member 2 (ABCG2) is a well‐defined efflux transporter found in a variety of tissues. The role of ABCG2 during early…”
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Gene expression analysis in the ventral prostate of rats exposed to vinclozolin or procymidone by Rosen, Mitchell B., Wilson, Vickie S., Schmid, Judith E., Gray, L. Earl

“…Vinclozolin and procymidone are antiandrogens that are thought to share a common androgen receptor (AR) mediated mechanism of action. This assessment is based…”
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Developmental effects of maternal stress in the CD-1 mouse induced by restraint on single days during the period of major organogenesis by Chernoff, N, Miller, D B, Rosen, M B, Mattscheck, C L

“…Maternal stress during gestation can produce significant fetal and/or postnatal effects, and can enhance the teratogenicity of other agents. We have previously…”
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5-Aza-2′-deoxycytidine-induced cytotoxicity and limb reduction defects in the mouse by Rosen, Mitchell B., Chernoff, Neil

“…Background 5‐Aza‐2′‐deoxycytidine (dAZA), causes hindlimb phocomelia in CD‐1 mice. Studies in our laboratory have examined the hypothesis that compound‐…”
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Gene expression profiling in the liver and lung of perfluorooctane sulfonate-exposed mouse fetuses: Comparison to changes induced by exposure to perfluorooctanoic acid: Recent Advances in Perfluoroalkyl Acid Research by ROSEN, Mitchell B, SCHMID, Judith E, DAS, Kaberi P, WOOD, Carmen R, ZEHR, Robert D, LAU, Christopher

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Gene Expression Profiling in Wild-Type and PPARα-Null Mice Exposed to Perfluorooctane Sulfonate Reveals PPARα-Independent Effects by Schmid, Judith R., Rosen, Mitchell B., Corton, J. Christopher, Zehr, Robert D., Das, Kaberi P., Abbott, Barbara D., Lau, Christopher S.

“…Perfluorooctane sulfonate (PFOS) is a perfluoroalkyl acid (PFAA) and a persistent environmental contaminant found in the tissues of humans and wildlife…”
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Gene expression analysis in the ventral prostate of rats exposed to vinclozolin or procymidone: Systems biology/Computational toxicology by ROSEN, Mitchell B, WILSON, Vickie S, SCHMID, Judith E, GRAY, L. Earl

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Effects of chemically induced maternal toxicity on prenatal development in the rat by Chernoff, N, Setzer, R W, Miller, D B, Rosen, M B, Rogers, J M

“…The hypothesis that chemically induced overt maternal toxicity induces a characteristic syndrome of adverse developmental effects in the rat was investigated…”
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Cyclophosphamide teratogenesis: evidence for compensatory responses to induced cellular toxicity by Francis, B M, Rogers, J M, Sulik, K K, Alles, A J, Elstein, K H, Zucker, R M, Massaro, E J, Rosen, M B, Chernoff, N

“…Cyclophosphamide (CP) administered ip to pregnant mice on day 10 of gestation (day of plug = day 0) is teratogenic (exencephaly, cleft palate, and limb…”
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