Search Results - "Rosen, Michael R"

Microplastics in Lake Mead National Recreation Area, USA: Occurrence and biological uptake by Baldwin, Austin K, Spanjer, Andrew R, Rosen, Michael R, Thom, Theresa

“…Microplastics are an environmental contaminant of growing concern, but there is a lack of information about microplastic distribution, persistence,…”
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Mechanisms of Earthquake‐Induced Chemical and Fluid Transport to Carbonate Groundwater Springs After Earthquakes by Rosen, Michael R., Binda, Gilberto, Archer, Claire, Pozzi, Andrea, Michetti, Alessandro M., Noble, Paula J.

“…Mechanisms by which hydrochemical changes occur after earthquakes are not well documented. We use the 2016–2017 central Italy seismic sequence, which caused…”
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Human Embryonic and Induced Pluripotent Stem Cell-Derived Cardiomyocytes Exhibit Beat Rate Variability and Power-Law Behavior by MANDEL, Yael, WEISSMAN, Amir, BINAH, Ofer, SCHICK, Revital, BARAD, Lili, NOVAK, Atara, MEIRY, Gideon, GOLDBERG, Stanislav, LORBER, Avraham, ROSEN, Michael R, ITSKOVITZ-ELDOR, Joseph

“…The sinoatrial node is the main impulse-generating tissue in the heart. Atrioventricular conduction block and arrhythmias caused by sinoatrial node dysfunction…”
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Application of blebbistatin as an excitation–contraction uncoupler for electrophysiologic study of rat and rabbit hearts by Fedorov, Vadim V., PhD, Lozinsky, Ilya T., PhD, Sosunov, Eugene A., PhD, Anyukhovsky, Evgeniy P., PhD, Rosen, Michael R., MD, Balke, C. William, MD, PhD, Efimov, Igor R., PhD

“…Background Application of fluorescence imaging of cardiac electrical activity is limited by motion artifacts and/or side effects of currently available…”
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Mesenchymal Stem Cells Support Migration, Extracellular Matrix Invasion, Proliferation, and Survival of Endothelial Cells In Vitro by Potapova, Irina A., Gaudette, Glenn R., Brink, Peter R., Robinson, Richard B., Rosen, Michael R., Cohen, Ira S., Doronin, Sergey V.

“…We investigated effects of the paracrine factors secreted by human mesenchymal stem cells (hMSCs) on endothelial cell migration, extracellular matrix invasion,…”
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Induced Pluripotent Stem Cell-Derived Cardiomyocytes Provide In Vivo Biological Pacemaker Function by Chauveau, Samuel, Anyukhovsky, Evgeny P, Ben-Ari, Meital, Naor, Shulamit, Jiang, Ya-Ping, Danilo, Jr, Peter, Rahim, Tania, Burke, Stephanie, Qiu, Xiaoliang, Potapova, Irina A, Doronin, Sergey V, Brink, Peter R, Binah, Ofer, Cohen, Ira S, Rosen, Michael R

“…Although multiple approaches have been used to create biological pacemakers in animal models, induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs)…”
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Increased Persistent Sodium Current Due to Decreased PI3K Signaling Contributes to QT Prolongation in the Diabetic Heart by ZHONGJU LU, JIANG, Ya-Ping, WU, Chia-Yen C, BALLOU, Lisa M, SHENGNAN LIU, CARPENTER, Eileen S, ROSEN, Michael R, COHEN, Ira S, LIN, Richard Z

“…Diabetes is an independent risk factor for sudden cardiac death and ventricular arrhythmia complications of acute coronary syndrome. Prolongation of the QT…”
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Regulation of heart rate and the pacemaker current by phosphoinositide 3-kinase signaling by Lin, Richard Z, Lu, Zhongju, Anyukhovsky, Evgeny P, Jiang, Ya-Ping, Wang, Hong Zhan, Gao, Junyuan, Rosen, Michael R, Ballou, Lisa M, Cohen, Ira S

“…Heart rate in physiological conditions is set by the sinoatrial node (SN), the primary cardiac pacing tissue. Phosphoinositide 3-kinase (PI3K) signaling is a…”
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Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart by Li, Ning, Csepe, Thomas A, Hansen, Brian J, Dobrzynski, Halina, Higgins, Robert S D, Kilic, Ahmet, Mohler, Peter J, Janssen, Paul M L, Rosen, Michael R, Biesiadecki, Brandon J, Fedorov, Vadim V

“…The hyperpolarization-activated current, If, plays an important role in sinoatrial node (SAN) pacemaking. Surprisingly, the distribution of…”
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Developmental changes in electrophysiological characteristics of human induced Pluripotent Stem Cell-derived cardiomyocytes by Ben-Ari, Meital, M.Sc, Naor, Shulamit, M.Sc, Zeevi-Levin, Naama, Ph.D, Schick, Revital, M.Sc, Jehuda, Ronen Ben, M.Sc, Reiter, Irina, M.Sc, Raveh, Amit, B.Sc, Grijnevitch, Inna, B.Sc, Barak, Omri, Ph.D, Rosen, Michael R., M.D, Weissman, Amir, M.D, Binah, Ofer, Ph.D

“…Background Previous studies proposed that throughout differentiation of human induced Pluripotent Stem Cell-derived cardiomyocytes (iPSC-CMs) only 3 types of…”
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From beat rate variability in induced pluripotent stem cell–derived pacemaker cells to heart rate variability in human subjects by Ben-Ari, Meital, BSc, Schick, Revital, BSc, Barad, Lili, BSc, Novak, Atara, MSc, Ben-Ari, Erez, BSc, Lorber, Avraham, MD, Itskovitz-Eldor, Joseph, MD, PhD, Rosen, Michael R., MD, FHRS, Weissman, Amir, MD, Binah, Ofer, PhD

“…Background We previously reported that induced pluripotent stem cell–derived cardiomyocytes manifest beat rate variability (BRV) resembling heart rate…”
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Cardiac memory: The slippery slope twixt normalcy and pathology by Rosen, Michael R., MD, Bergfeldt, Lennart, MD, PhD

“…Abstract “Cardiac memory” is an altered repolarization phenotype resulting from prior cardiac rate, rhythm, and/or activation changes. The various types of…”
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Defective cardiac ryanodine receptor regulation during atrial fibrillation by VEST, John A, WEHRENS, Xander H. T, REIKEN, Steven R, LEHNART, Stephan E, DOBREV, Dobromir, CHANDRA, Parag, DANILO, Peter, RAVENS, Ursula, ROSEN, Michael R, MARKS, Andrew R

“…Ca2+ leak from the sarcoplasmic reticulum (SR) may play an important role in triggering and/or maintaining atrial arrhythmias, including atrial fibrillation…”
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Xenografted adult human mesenchymal stem cells provide a platform for sustained biological pacemaker function in canine heart by PLOTNIKOV, Alexei N, SHLAPAKOVA, Iryna, ROBINSON, Richard B, COHEN, Ira S, ROSEN, Michael R, SZABOLCS, Matthias J, DANILO, Peter, LORELL, Beverly H, POTAPOVA, Irina A, ZHONGJU LU, ROSEN, Amy B, MATHIAS, Richard T, BRINK, Peter R

“…Biological pacemaking has been performed with viral vectors, human embryonic stem cells, and adult human mesenchymal stem cells (hMSCs) as delivery systems…”
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Dispersion of repolarization in canine ventricle and the electrocardiographic T wave: Tp-e interval does not reflect transmural dispersion by Opthof, Tobias, PhD, Coronel, Ruben, MD, Wilms-Schopman, Francien J.G, Plotnikov, Alexei N., MD, Shlapakova, Iryna N., MD, Danilo, Peter, PhD, Rosen, Michael R., MD, Janse, Michiel J., MD

“…Background The concept that the interval between the peak (Tpeak ) and the end (Tend ) of the T wave (Tp-e ) is a measure of transmural dispersion of…”
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HCN2/SkM1 Gene Transfer Into Canine Left Bundle Branch Induces Stable, Autonomically Responsive Biological Pacing at Physiological Heart Rates by Boink, Gerard J.J., MSc, Duan, Lian, MD, Nearing, Bruce D., PhD, Shlapakova, Iryna N., MD, Sosunov, Eugene A., PhD, Anyukhovsky, Evgeny P., PhD, Bobkov, Eugene, BSC, Kryukova, Yelena, PhD, Ozgen, Nazira, MD, PhD, Danilo, Peter, PhD, Cohen, Ira S., MD, PhD, Verrier, Richard L., PhD, Robinson, Richard B., PhD, Rosen, Michael R., MD

“…Objectives This study sought to test the hypothesis that hyperpolarization-activated cyclic nucleotide–gated (HCN)–based biological pacing might be improved…”
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Accessory Subunit KChIP2 Modulates the Cardiac L-Type Calcium Current by Thomsen, Morten B, Wang, Chaojian, Özgen, Nazira, Wang, Hong-Gang, Rosen, Michael R, Pitt, Geoffrey S

“…Complex modulation of voltage-gated Ca currents through the interplay among Ca channels and various Ca-binding proteins is increasingly being recognized. The K…”
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The case for the funny current and the calcium clock by Rosen, Michael R., MD, FHRS, Nargeot, Joel, PhD, Salama, Guy, PhD, FHRS

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The influence of irrigation water on the hydrology and lake water budgets of two small arid-climate lakes in Khorezm, Uzbekistan by Scott, Julian, Rosen, Michael R., Saito, Laurel, Decker, David L.

“…► Little known regarding origins and hydrology of numerous small lakes in Uzbekistan. ► These arid-climate lakes may offer potential utility. ► Study concluded…”
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Peter M. Spooner, November 11, 1942–January 30, 2016 by Lathrop, David A., PhD, Rosen, Michael R., MD

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