Search Results - "Rosen, Kenneth M."

A Critical Period for Social Experience—Dependent Oligodendrocyte Maturation and Myelination by Makinodan, Manabu, Rosen, Kenneth M., Ito, Susumu, Corfas, Gabriel

“…Early social isolation results in adult behavioral and cognitive dysfunction that correlates with white matter alterations. However, how social deprivation…”
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MAG, myelin and overcoming growth inhibition in the CNS by McKerracher, Lisa, Rosen, Kenneth M

“…While neurons in the central nervous system (CNS) have the capacity to regenerate their axons after injury, they fail to do so, in part because regeneration is…”
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Nerve injury induces glial cell line-derived neurotrophic factor (gdnf) expression in schwann cells through purinergic signaling and the pkc-pkd pathway by Xu, Pin, Rosen, Kenneth M., Hedstrom, Kristian, Rey, Osvaldo, Guha, Sushovan, Hart, Courtney, Corfas, Gabriel

“…Upon peripheral nerve injury, specific molecular events, including increases in the expression of selected neurotrophic factors, are initiated to prepare the…”
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Potential primary roles of glial cells in the mechanisms of psychiatric disorders by Yamamuro, Kazuhiko, Kimoto, Sohei, Rosen, Kenneth M, Kishimoto, Toshifumi, Makinodan, Manabu

“…While neurons have long been considered the major player in multiple brain functions such as perception, emotion, and memory, glial cells have been relegated…”
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Cell-Free Embryonic Stem Cell Extract–Mediated Derivation of Multipotent Stem Cells From NIH3T3 Fibroblasts for Functional and Anatomical Ischemic Tissue Repair by Rajasingh, Johnson, Lambers, Erin, Hamada, Hiromichi, Bord, Evelyn, Thorne, Tina, Goukassian, Ilona, Krishnamurthy, Prasanna, Rosen, Kenneth M, Ahluwalia, Deepali, Zhu, Yan, Qin, Gangjian, Losordo, Douglas W, Kishore, Raj

“…The oocyte-independent source for the generation of pluripotent stem cells is among the ultimate goals in regenerative medicine. We report that on exposure to…”
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Self-delivering RNAi compounds as therapeutic agents in the central nervous system to enhance axonal regeneration after injury by Woller, Sarah A., Ruschel, Joerg, Morquette, Barbara, Cardia, James, Yan, Dinxue, Holton, Katherine, Shmushkovich, Taisia, Niederst, Emily, Bulock, Karen, Wolfson, Alexey, Abbinanti, Matthew, Fournier, Alyson E., McKerracher, Lisa, Rosen, Kenneth M.

“…The therapeutic use of RNAi has grown but often faces several hurdles related to delivery systems, compound stability, immune activation, and…”
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ARIA : A neuromuscular junction neuregulin by FISCHBACH, G. D, ROSEN, K. M

“…Motor neurons influence the expression and the distribution of acetylcholine receptors in skeletal muscle. Molecules that mediate this carefully choreographed…”
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The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid by Lee, Han-Kyu, Kumar, Pravir, Fu, Qinghao, Rosen, Kenneth M, Querfurth, Henry W

“…Intraneuronal beta-amyloid (Abeta(i)) accumulates early in Alzheimer's disease (AD) and inclusion body myositis. Several organelles, receptor molecules,…”
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Mickey, Can You Spare a Dime? "Disneywar", Executive Compensation, Corporate Governance, and Business Law Pedagogy by Rosen, Kenneth M.

“…American business executives are under fire. Recent, notorious difficulties at companies such as the Enron Corporation brought attention to these individuals…”
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Differential Effects of Mitochondrial Heat Shock Protein 60 and Related Molecular Chaperones to Prevent Intracellular β-Amyloid-induced Inhibition of Complex IV and Limit Apoptosis by Veereshwarayya, Vimal, Kumar, Pravir, Rosen, Kenneth M., Mestril, Ruben, Querfurth, Henry W.

“…Defects in mitochondrial oxidative metabolism, in particular decreased activity of cytochrome c oxidase, have been reported in Alzheimer disease tissue and in…”
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Biological function of nuclear receptor tyrosine kinase action by Song, Sungmin, Rosen, Kenneth M, Corfas, Gabriel

“…Receptor tyrosine kinases (RTKs) were believed until recently to act at the cell membrane in a singular fashion (i.e., binding of ligands on the extracellular…”
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CHIP and HSPs interact with β-APP in a proteasome-dependent manner and influence Aβ metabolism by Kumar, Pravir, Ambasta, Rashmi K., Veereshwarayya, Vimal, Rosen, Kenneth M., Kosik, Ken S., Band, Hamid, Mestril, Ruben, Patterson, Cam, Querfurth, Henry W.

“…The C-terminus Hsp70 interacting protein (CHIP) has dual function as both co-chaperone and ubiquitin ligase. CHIP is increasingly implicated in the biology of…”
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Parkin reverses intracellular β-amyloid accumulation and its negative effects on proteasome function by Rosen, Kenneth M., Moussa, Charbel E.-H., Lee, Han-Kyu, Kumar, Pravir, Kitada, Tohru, Qin, Gangjian, Fu, Qinghao, Querfurth, Henry W.

“…The significance of intracellular β‐amyloid (Aβ42) accumulation is increasingly recognized in Alzheimer's disease (AD) pathogenesis. Aβ removal mechanisms that…”
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Intraneuronal beta-amyloid expression downregulates the Akt survival pathway and blunts the stress response by Magrané, Jordi, Rosen, Kenneth M, Smith, Roy C, Walsh, Kenneth, Gouras, Gunnar K, Querfurth, Henry W

“…Early events in Alzheimer's disease (AD) pathogenesis implicate the accumulation of beta-amyloid (Abeta) peptide inside neurons in vulnerable brain regions…”
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Parkin Protects against Mitochondrial Toxins and β-Amyloid Accumulation in Skeletal Muscle Cells by Rosen, Kenneth M., Veereshwarayya, Vimal, Moussa, Charbel E-H., Fu, Qinghao, Goldberg, Matthew S., Schlossmacher, Michael G., Shen, Jie, Querfurth, Henry W.

“…Mutations in the ubiquitin ligase-encoding Parkin gene have been implicated in the pathogenesis of autosomal recessive Parkinson disease. Outside of the…”
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Antiangiogenesis mediates cisplatin-induced peripheral neuropathy : Attenuation or reversal by local vascular endothelial growth factor gene therapy without augmenting tumor growth by KIRCHMAIR, Rudolf, WALTER, Dirk H, SCHRATZBERGER, Peter, YOON, Young-Sup, WEBER, Alberto, PANAGIOTOU, Eleftheria, ROSEN, Kenneth M, BAHLMANN, Ferdinand H, ADELMAN, Lester S, WEINBERG, David H, ROPPER, Allan H, ISNER, Jeffrey M, II, Masaaki, LOSORDO, Douglas W, RITTIG, Kilian, TIETZ, Anne B, MURAYAMA, Toshinori, EMANUELI, Costanza, SILVER, Marcy, WECKER, Andrea, AMANT, Carole

“…Toxic neuropathies induced by cisplatin and other chemotherapeutic agents are important clinical problems because of their high incidence, their lack of…”
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"Who Killed Katie Couric?" and Other Tales from the World of Executive Compensation Reform by Rosen, Kenneth M

“…With average Americans perturbed about executive pay, government officials are taking action. Officials appear to be racing against each other to battle…”
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Transgenic expression of β-APP in fast-twitch skeletal muscle leads to calcium dyshomeostasis and IBM-like pathology by Moussa, Charbel E.H, Fu, Qinghao, Kumar, Pravir, Shtifman, Alexander, Lopez, Jose R, Allen, Paul D, LaFerla, Frank, Weinberg, David, Magrane, Jordi, Aprahamian, Tamar, Walsh, Kenneth, Rosen, Kenneth M, Querfurth, Henry W

“…Intracellular deposition of the β-amyloid (Aβ) peptide is an increasingly recognized pathological hallmark associated with neurodegeneration and muscle wasting…”
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Maintenance of Acetylcholine Receptor Number by Neuregulins at the Neuromuscular Junction in Vivo by Sandrock, Alfred W., Dryer, Stuart E., Rosen, Kenneth M., Gozani, Shai N., Kramer, Rainer, Theill, Lars E., Fischbach, Gerald D.

“…ARIA (for acetylcholine receptor-inducing activity), a protein purified on the basis of its ability to stimulate acetylcholine receptor (AChR) synthesis in…”
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Differential expression of ARIA isoforms in the rat brain by Corfas, Gabriel, Rosen, Kenneth M, Aratake, Hisashi, Krauss, Raul, Fischbach, Gerald D

“…ARIA, heregulin, neu differentiation factor, and glial growth factor are members of a new family of growth and differentiation factors whose effects have been…”
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