Search Results - "Rosen, Eliot M."
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DIM (3,3′-diindolylmethane) confers protection against ionizing radiation by a unique mechanism
Published in Proceedings of the National Academy of Sciences - PNAS (12-11-2013)“…DIM (3,3′-diindolylmethane), a small molecule compound, is a proposed cancer preventive agent that can be safely administered to humans in repeated doses. We…”
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Targeting the BRCA1/2 tumor suppressors
Published in Current drug targets (01-01-2014)“…The breast cancer susceptibility genes BRCA1 and BRCA2 are classic tumor suppressor genes that exhibit an autosomal dominant pattern of inheritance with high…”
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Transcriptional Regulation of the Base Excision Repair Pathway by BRCA1
Published in The Journal of biological chemistry (18-06-2010)“…Inactivation of the breast cancer susceptibility gene BRCA1 plays a significant role in the development of a subset of breast cancers, although the major tumor…”
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BRCA1 down-regulates cellular levels of reactive oxygen species
Published in FEBS letters (06-05-2009)“…Previous studies have shown that the breast cancer suppressor BRCA1 stimulates antioxidant gene expression and protects cells against oxidative stress. To…”
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Interlaced X-Ray Microplanar Beams: A Radiosurgery Approach with Clinical Potential
Published in Proceedings of the National Academy of Sciences - PNAS (20-06-2006)“…Studies have shown that x-rays delivered as arrays of parallel microplanar beams (microbeams), 25- to 90-μm thick and spaced 100-300 μm on-center,…”
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BRCA1 Localization to the Telomere and Its Loss from the Telomere in Response to DNA Damage
Published in The Journal of biological chemistry (25-12-2009)“…BRCA1, a tumor suppressor, participates in DNA damage signaling and repair. Previously, we showed that BRCA1 overexpression caused inhibition of telomerase…”
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Transcription-dependent epidermal growth factor receptor activation by hepatocyte growth factor
Published in Molecular cancer research (01-01-2008)“…The mechanisms and biological implications of coordinated receptor tyrosine kinase coactivation remain poorly appreciated. Epidermal growth factor receptor…”
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BRCA1 induces antioxidant gene expression and resistance to oxidative stress
Published in Cancer research (Chicago, Ill.) (01-11-2004)“…Mutations of the breast cancer susceptibility gene 1 (BRCA1), a tumor suppressor, confer an increased risk for breast, ovarian, and prostate cancers. To…”
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BRCA1 gene in breast cancer
Published in Journal of cellular physiology (01-07-2003)“…The BRCA1 gene was identified and cloned in 1994 based its linkage to early onset breast cancer and breast‐ovarian cancer syndromes in women. While inherited…”
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BRCA1 Inhibits Membrane Estrogen and Growth Factor Receptor Signaling to Cell Proliferation in Breast Cancer
Published in Molecular and Cellular Biology (01-07-2004)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Role of Src Signal Transduction Pathways in Scatter Factor-mediated Cellular Protection
Published in The Journal of biological chemistry (20-03-2009)“…Scatter factor (SF) (hepatocyte growth factor) is a pleiotrophic cytokine that accumulates in tumors, where it may induce invasion, angiogenesis, and…”
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BRCA1 regulation of base excision repair pathway
Published in Cell cycle (Georgetown, Tex.) (01-07-2010)“…This feature item briefly reviews the relation of the tumor suppressor function of BRCA1 with DNA damage and repair. The main focus of this article is on the…”
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The Breast Cancer Susceptibility Gene BRCA1 Regulates Progesterone Receptor Signaling in Mammary Epithelial Cells
Published in Molecular endocrinology (Baltimore, Md.) (01-01-2006)“…The progesterone receptor (PR) plays roles in normal mammary development and breast cancer formation, where it may exert both stimulatory and inhibitory…”
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BRCA1 Interaction with Human Papillomavirus Oncoproteins
Published in The Journal of biological chemistry (30-09-2005)“…Previously, we reported that BRCA1 strongly represses the transcriptional activity of estrogen receptor-α (ER-α) in human breast and prostate cancer cells but…”
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BRCA1 regulates follistatin function in ovarian cancer and human ovarian surface epithelial cells
Published in PloS one (01-06-2012)“…Follistatin (FST), a folliculogenesis regulating protein, is found in relatively high concentrations in female ovarian tissues. FST acts as an antagonist to…”
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In vivo targeting of SF/HGF and c‐met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis
Published in The FASEB journal (01-01-2002)“…The multifunctional growth factor scatter factor/hepatocyte growth factor (SF/HGF) and its receptor c‐met have been implicated in the genesis, malignant…”
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Ribotoxic Stress Sensitizes Glioblastoma Cells to Death Receptor–Induced Apoptosis: Requirements for c-Jun NH2-Terminal Kinase and Bim
Published in Molecular cancer research (01-08-2007)“…A prominent feature of glioblastoma is its resistance to death receptor–mediated apoptosis. In this study, we explored the possibility of modulating death…”
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BRCA1 Modulates Xenobiotic Stress-inducible Gene Expression by Interacting with ARNT in Human Breast Cancer Cells
Published in The Journal of biological chemistry (26-05-2006)“…Previously, we have reported that BRCA1 regulates the expression of various classes of genes, including genes involved in xenobiotic stress responses (Bae, I.,…”
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New approaches to radiation protection
Published in Frontiers in oncology (20-01-2015)“…Radioprotectors are compounds that protect against radiation injury when given prior to radiation exposure. Mitigators can protect against radiation injury…”
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Murine EMT-6 Carcinoma: High Therapeutic Efficacy of Microbeam Radiation Therapy
Published in Radiation research (01-05-2003)“…Dilmanian, F. A., Morris, G. M., Zhong, N., Bacarian, T., Hainfeld, J. F., Kalef-Ezra, J., Brewington, L. J., Tammam, J. and Rosen, E. M. Murine EMT-6…”
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