Association of oxytocin levels and oxytocin receptor gene polymorphism (rs2254298) with cardiovascular risk factors in Brazilian elderly from Primary Health Care

Association of oxytocin levels and oxytocin receptor gene polymorphism (rs2254298) with cardiovascular risk factors in Brazilian elderly from Primary Health Care

•There was no association of oxytocin receptor gene polymorphism (OXTR rs 2254298) with cardiovascular risk factors.•The elderly with higher dosages of oxytocin had lower concentrations of postprandial triglycerides.•On Poisson regression analysis, OT remained a predictor for leanness. Morbidity and...

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Published in:Archives of gerontology and geriatrics Vol. 84; p. 103903
Main Authors: Jacondino, Camila Bittencourt, Borges, Cristiane Alves, Rosemberg, Laura Schlater, da Silva, Irênio Gomes, da Luz Correa, Bruna, Valle Gottlieb, Maria Gabriela
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01-09-2019
Subjects:
Aged
Aged, 80 and over
Aging
Cardiovascular Diseases - etiology
Cardiovascular Risk factors
Cross-Sectional Studies
Female
Genetic polymorphism
Humans
Male
OXTR polymorphism
Oxytocin
Oxytocin - blood
Polymorphism, Genetic
Primary Health Care
Receptors, Oxytocin - genetics
Risk Factors
Triglycerides - blood
Cardiovascular Risk factors
Aging
Oxytocin
Genetic polymorphism
OXTR polymorphism
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Summary:•There was no association of oxytocin receptor gene polymorphism (OXTR rs 2254298) with cardiovascular risk factors.•The elderly with higher dosages of oxytocin had lower concentrations of postprandial triglycerides.•On Poisson regression analysis, OT remained a predictor for leanness. Morbidity and mortality from cardiovascular disease is a typical phenomenon in the elderly, and are related to unfavorable genetic, hormonal and environmental (lifestyle) interactions. In this context, oxytocin (OT) seems plays a key role in the development of CVD by performing important actions in metabolism energy and hemodynamic variables. To verify if there is an association between (OT) levels and the oxytocin receptor gene (OXTR) polymorphism (rs2254298) with cardiovascular risk factors (CRF) in the elderly. This was a cross-sectional study in community-dwelling elderly attending primary health care. The genotyping was done using the polymerase chain reaction technique. The CRF factors investigated included hypertension, diabetes mellitus, dyslipidemia, sedentary lifestyle, and obesity. Levels of triglycerides (TGC) postprandial and glucose were measured in capillary blood. OT and cortisol levels were measured by enzyme-linked immunosorbent assay (ELISA). The sample comprised 177 elderly individuals. OT levels showed a significant negative correlation with postprandial triglycerides (p = 0.030) and BMI (p = 0.019). OT levels were also associated with leanness (p = 0.005). On Poisson regression analysis, OT remained a predictor for leanness (p = 0.010). No significant associations were observed between the OXTR polymorphism and CRF. The results suggest that Postprandial TGC levels are increased, while OT levels are decreased, and this hormone was significantly elevated in lean elderly. Future studies are needed to confirm these findings, and the role of OT in metabolic parameters.
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ISSN:0167-4943
1872-6976
DOI:10.1016/j.archger.2019.103903