Search Results - "Rosemarie B. Lichtner"

Total Synthesis and Antitumor Activity of ZK-EPO: The First Fully Synthetic Epothilone in Clinical Development by Klar, Ulrich, Buchmann, Bernd, Schwede, Wolfgang, Skuballa, Werner, Hoffmann, Jens, Lichtner, Rosemarie B.

“…Going to trial: From about 350 active epothilone analogues synthesized by a highly convergent synthesis, one (ZK‐EPO, see picture) has been chosen for clinical…”
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Construction of a Computable Network Model for DNA Damage, Autophagy, Cell Death, and Senescence by Gebel, Stephan, Lichtner, Rosemarie B., Frushour, Brian, Schlage, Walter K., Hoang, Vy, Talikka, Marja, Hengstermann, Arnd, Mathis, Carole, Veljkovic, Emilija, Peck, Michael, Peitsch, Manuel C., Deehan, Renee, Hoeng, Julia, Westra, Jurjen W.

“…Towards the development of a systems biology-based risk assessment approach for environmental toxicants, including tobacco products in a systems toxicology…”
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A Modular Cell-Type Focused Inflammatory Process Network Model for Non-Diseased Pulmonary Tissue by Westra, Jurjen W., Schlage, Walter K., Hengstermann, Arnd, Gebel, Stephan, Mathis, Carole, Thomson, Ty, Wong, Ben, Hoang, Vy, Veljkovic, Emilija, Peck, Michael, Lichtner, Rosemarie B., Weisensee, Dirk, Talikka, Marja, Deehan, Renee, Hoeng, Julia, Peitsch, Manuel C.

“…Exposure to environmental stressors such as cigarette smoke (CS) elicits a variety of biological responses in humans, including the induction of inflammatory…”
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Systematic Verification of Upstream Regulators of a Computable Cellular Proliferation Network Model on Non-Diseased Lung Cells Using a Dedicated Dataset by Belcastro, Vincenzo, Poussin, Carine, Gebel, Stephan, Mathis, Carole, Schlage, Walter K., Lichtner, Rosemarie B., Quadt-Humme, Sibille, Wagner, Sandra, Hoeng, Julia, Peitsch, Manuel C.

“…We recently constructed a computable cell proliferation network (CPN) model focused on lung tissue to unravel complex biological processes and their…”
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Studies on the development of resistance to the pure antiestrogen Faslodex™ in three human breast cancer cell lines by Sommer, Anette, Hoffmann, Jens, Lichtner, Rosemarie B., Schneider, Martin R., Parczyk, Karsten

“…In order to understand the mechanisms underlying the development of resistance to a pure antiestrogen we established three human breast carcinoma cell lines…”
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Improved Cellular Pharmacokinetics and Pharmacodynamics Underlie the Wide Anticancer Activity of Sagopilone by HOFFMANN, Jens, VILALE, Ilio, PANARETAKIS, Theocharis, SIEMEISTER, Gerhard, LAGE, Hermann, NANTY, Lisa, HAMMER, Stefanie, MITTELSTAEDT, Kevin, WINSEL, Sebastian, ESCHENBRENNER, Julia, CASTEDO, Maria, DEMARCHE, Carine, BUCHMANN, Bernd, KLAR, Ulrich, KROEMER, Guido, GALLUZZI, Lorenzo, SCHWEDE, Wolfgang, SENOVILLA, Laura, SKUBALLA, Werner, VIVET, Sonia, LICHTNER, Rosemarie B, VICENCIO, José M

“…Sagopilone (ZK-EPO) is the first fully synthetic epothilone undergoing clinical trials for the treatment of human tumors. Here, we investigate the cellular…”
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Towards the validation of a lung tumorigenesis model with mainstream cigarette smoke inhalation using the A/J mouse by Stinn, Walter, Berges, An, Meurrens, Kris, Buettner, Ansgar, Gebel, Stephan, Lichtner, Rosemarie B, Janssens, Kris, Veljkovic, Emilija, Xiang, Yang, Roemer, Ewald, Haussmann, Hans-Juergen

“…Highlights ► Reliability of the assay was shown by intra- and inter-laboratory reproducibility. ► Robustness was shown by comparison to historic data. ►…”
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Construction of a computable cell proliferation network focused on non-diseased lung cells by Westra, Jurjen W, Schlage, Walter K, Frushour, Brian P, Gebel, Stephan, Catlett, Natalie L, Han, Wanjiang, Eddy, Sean F, Hengstermann, Arnd, Matthews, Andrea L, Mathis, Carole, Lichtner, Rosemarie B, Poussin, Carine, Talikka, Marja, Veljkovic, Emilija, Van Hooser, Aaron A, Wong, Benjamin, Maria, Michael J, Peitsch, Manuel C, Deehan, Renee, Hoeng, Julia

“…Critical to advancing the systems-level evaluation of complex biological processes is the development of comprehensive networks and computational methods to…”
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Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors by LICHTNER, Rosemarie B, MENRAD, Andreas, SOMMER, Anette, KLAR, Ulrich, SCHNEIDER, Martin R

“…Several inhibitors of EGF receptor (EGFR) tyrosine kinase activity have been developed that compete with ATP at its binding site such as the quinazolines PD…”
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Estrogen/EGF receptor interactions in breast cancer: rationale for new therapeutic combination strategies by Lichtner, Rosemarie B.

“…In the therapy of estrogen receptor (ER) positive human mammary carcinomas, the treatment with the antiestrogen tamoxifen has been well established. However,…”
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Characterization of new estrogen receptor destabilizing compounds: Effects on estrogen-sensitive and tamoxifen-resistant breast cancer by HOFFMANN, Jens, BOHLMANN, Rolf, GIESCHEN, Hille, ULBRICH, Hannes-F, SCHNEIDER, Martin R, HEINRICH, Nikolaus, HOFMEISTER, Helmut, KROLL, Jörg, KÜNZER, Hermann, LICHTNER, Rosemarie B, NISHINO, Yuki, PARCZYK, Karsten, SAUER, Gerhard

“…Antiestrogens of the selective estrogen receptor modulator (SERM) type, such as tamoxifen, have two major limitations: their mixed agonist and antagonist…”
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EGF receptor targeting in therapy-resistant human tumors by Schmidt, Mathias, Lichtner, Rosemarie B

“…The development of resistance against cytotoxic or endocrine therapy limits the number of chemotherapeutic compounds used in the clinic. The receptor for EGF…”
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Selective increase of ?2-integrin sub-unit expression on human carcinoma cells upon EGF-receptor activation by Krensel, Kirstin, Lichtner, Rosemarie B.

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Cellular distribution and biological activity of epidermal growth factor receptors in A431 cells are influenced by cell-cell contact by Lichtner, R B, Schirrmacher, V

“…The potential significance of cell-cell interactions on EGF receptor (EGFR) activity was investigated in cultured adherent A431 cells seeded as single-cell…”
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Estrogen/EGF receptor interactions in breast cancer: rationale for new therapeutic combination strategies : Breast cancers by LICHTNER, Rosemarie B

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Cover Picture: Total Synthesis and Antitumor Activity of ZK-EPO: The First Fully Synthetic Epothilone in Clinical Development (Angew. Chem. Int. Ed. 47/2006) by Klar, Ulrich, Buchmann, Bernd, Schwede, Wolfgang, Skuballa, Werner, Hoffmann, Jens, Lichtner, Rosemarie B.

“…Nature is a brilliant architect for the design of compounds with interesting biological functions. Epothilone B (top), a metabolite of myxobacteria (fruiting…”
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Systematic Verification of Upstream Regulators of a Computable Cellular Proliferation Network Model on Non-Diseased Lung Cells Using a Dedicated Dataset by Vincenzo Belcastro, Carine Poussin, Stephan Gebel, Carole Mathis, Walter K. Schlage, Rosemarie B. Lichtner, Sibille Quadt-Humme, Sandra Wagner, Julia Hoeng, Manuel C. Peitsch

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EGF receptor in neoplasia and metastasis by Khazaie, K, Schirrmacher, V, Lichtner, R B

“…EGFR is a member of the tyrosine kinase family of cell surface receptors with a wide range of expression throughout development and in a variety of different…”
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A Modular Cell-Type Focused Inflammatory Process Network Model for Non-Diseased Pulmonary Tissue by Jurjen W. Westra, Walter K. Schlage, Arnd Hengstermann, Stephan Gebel, Carole Mathis, Ty Thomson, Ben Wong, Vy Hoang, Emilija Veljkovic, Michael Peck, Rosemarie B. Lichtner, Dirk Weisensee, Marja Talikka, Renee Deehan, Julia Hoeng, Manuel C. Peitsch

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Construction of a Computable Network Model for DNA Damage, Autophagy, Cell Death, and Senescence by Stephan Gebel, Rosemarie B. Lichtner, Brian Frushour, Walter K. Schlage, Vy Hoang, Marja Talikka, Arnd Hengstermann, Carole Mathis, Emilija Veljkovic, Michael Peck, Manuel C. Peitsch, Renee Deehan, Julia Hoeng, Jurjen W. Westra

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