Search Results - "Roselt, Peter D"

Effective Preparation of [ 18 F]Flumazenil Using Copper-Mediated Late-Stage Radiofluorination of a Stannyl Precursor by Haskali, Mohammad B, Roselt, Peter D, O'Brien, Terence J, Hutton, Craig A, Ali, Idrish, Vivash, Lucy, Jupp, Bianca

“…(1) Background: [18F]Flumazenil 1 ([18F]FMZ) is an established positron emission tomography (PET) radiotracer for the imaging of the gamma-aminobutyric acid…”
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Automated synthesis of [89Zr]ZrCl4, [89Zr]ZrDFOSquaramide-bisPh(PSMA) and [89Zr]ZrDFOSquaramide-TATE by Noor, Asif, Roselt, Peter D., McGowan, Emily R., Poniger, Stan, Wheatcroft, Michael P., Donnelly, Paul S.

“…Background Automated [ 89 Zr]Zr-radiolabeling processes have the potential to streamline the production of [ 89 Zr]Zr-labelled PET imaging agents. Most…”
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Automated preparation of clinical grade [68Ga]Ga-DOTA-CP04, a cholecystokinin-2 receptor agonist, using iPHASE MultiSyn synthesis platform by Haskali, Mohammad B., Roselt, Peter D., Binns, David, Hetsron, Amit, Poniger, Stan, Hutton, Craig A., Hicks, Rodney J.

“…Background Gallium-68 ([ 68 Ga]Ga) labelled radiopharmaceuticals have become a valuable tool in clinical practice using Positron Emission Tomography (PET)…”
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One-step radiosynthesis of 4-nitrophenyl 2-[18F]fluoropropionate ([18F]NFP); improved preparation of radiolabeled peptides for PET imaging by Haskali, Mohammad B., Roselt, Peter D., Karas, John A., Noonan, Wayne, Wichmann, Christian W., Katsifis, Andrew, Hicks, Rodney J., Hutton, Craig A.

“…The versatile 18F‐labeled prosthetic group, 4‐nitrophenyl 2‐[18F]fluoropropionate ([18F]NFP), was synthesized in a single step in 45 min from 4‐nitrophenyl…”
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A Bivalent Inhibitor of Prostate Specific Membrane Antigen Radiolabeled with Copper‐64 with High Tumor Uptake and Retention by Zia, Nicholas A., Cullinane, Carleen, Van Zuylekom, Jessica K., Waldeck, Kelly, McInnes, Lachlan E., Buncic, Gojko, Haskali, Mohammad B., Roselt, Peter D., Hicks, Rodney J., Donnelly, Paul S.

“…Molecules containing lysine‐ureido‐glutamate functional groups bind to the active site of prostate specific membrane antigen, which is overexpressed in…”
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Development of Highly Potent Clinical Candidates for Theranostic Applications against Cholecystokinin‑2 Receptor Positive Cancers by Corlett, Alicia, Pinson, Jo-Anne, Rahimi, Marwa N., Zuylekom, Jessica Van, Cullinane, Carleen, Blyth, Benjamin, Thompson, Philip E., Hutton, Craig A., Roselt, Peter D., Haskali, Mohammad B.

“…Peptide receptor radionuclide therapy (PRRT) is a promising form of systemic radiation therapy designed to eradicate cancer. Cholecystokinin-2 receptor (CCK2R)…”
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Bivalent Inhibitors of Prostate-Specific Membrane Antigen Conjugated to Desferrioxamine B Squaramide Labeled with Zirconium-89 or Gallium-68 for Diagnostic Imaging of Prostate Cancer by Noor, Asif, Van Zuylekom, Jessica K, Rudd, Stacey E, Waldeck, Kelly, Roselt, Peter D, Haskali, Mohammad B, Wheatcroft, Michael P, Yan, Eddie, Hicks, Rodney J, Cullinane, Carleen, Donnelly, Paul S

“…Prostate-specific membrane antigen (PSMA) is a carboxypeptidase that is overexpressed in prostate cancer and is an excellent candidate for targeted diagnostic…”
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A New Turn in Peptide-Based Imaging Agents: Foldamers Afford Improved Theranostics Targeting Cholecystokinin‑2 Receptor-Positive Cancer by Corlett, Alicia, Sani, Marc-Antoine, Van Zuylekom, Jessica, Ang, Ching-Seng, von Guggenberg, Elisabeth, Cullinane, Carleen, Blyth, Benjamin, Hicks, Rodney J, Roselt, Peter D, Thompson, Philip E, Hutton, Craig A, Haskali, Mohammad B

“…Proteins adopt unique folded secondary and tertiary structures that are responsible for their remarkable biological properties. This structural complexity is…”
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Copper Bis(thiosemicarbazonato)-stilbenyl Complexes That Bind to Amyloid‑β Plaques by Noor, Asif, Hayne, David J, Lim, SinChun, Van Zuylekom, Jessica K, Cullinane, Carleen, Roselt, Peter D, McLean, Catriona A, White, Jonathan M, Donnelly, Paul S

“…Alzheimer’s disease is characterized by the presence of extracellular amyloid-β plaques. Positron emission tomography (PET) imaging with tracers radiolabeled…”
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Modification of Biodistribution and Brain Uptake of Copper Bis(thiosemicarbazonato) Complexes by the Incorporation of Amine and Polyamine Functional Groups by Paterson, Brett M, Cullinane, Carleen, Crouch, Peter J, White, Anthony R, Barnham, Kevin J, Roselt, Peter D, Noonan, Wayne, Binns, David, Hicks, Rodney J, Donnelly, Paul S

“…The synthesis of new bis­(thiosemicarbazonato)­copper­(II) complexes featuring polyamine substituents via selective transamination reactions is presented…”
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Precision peptide theranostics: developing N - to C -terminus optimized theranostics targeting cholecystokinin-2 receptor by Rahimi, Marwa N, Corlett, Alicia, Van Zuylekom, Jessica, Sani, Marc Antoine, Blyth, Benjamin, Thompson, Philip, Roselt, Peter D, Haskali, Mohammad B

“…Peptides are ideal for theranostic development as they afford rapid target accumulation, fast clearance from background tissue, and exhibit good tissue…”
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Imaging Somatostatin Positive Tumors with Tyr3‑Octreotate/Octreotide Conjugated to Desferrioxamine B Squaramide Radiolabeled with either Zirconium-89 or Gallium-68 by Noor, Asif, Van Zuylekom, Jessica K, Rudd, Stacey E, Roselt, Peter D, Haskali, Mohammad B, Yan, Eddie, Wheatcroft, Michael, Hicks, Rodney J, Cullinane, Carleen, Donnelly, Paul S

“…Radiolabeled derivatives of Tyr3-octreotide and Tyr3-octreotate, synthetic analogues of the peptide hormone somatostatin, can be used for positron emission…”
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Gallium Fluoride Complexes with Acyclic Bispicolinic Ligands as Potential New Fluorine‐18 Labelled Imaging Agents by Koay, HuiJing, Haskali, Mohammad B., Roselt, Peter D., White, Jonathan M., Donnelly, Paul S.

“…The positron‐emitting radionuclide, fluorine‐18, is used to radiolabel molecules to develop tracers for diagnostic imaging with positron‐emission tomography…”
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Therapeutic Efficacy of a Bivalent Inhibitor of Prostate-Specific Membrane Antigen Labeled with 67Cu by McInnes, Lachlan E, Cullinane, Carleen, Roselt, Peter D, Jackson, Susan, Blyth, Benjamin J, van Dam, Ellen M, Zia, Nicholas A, Harris, Matthew J, Hicks, Rodney J, Donnelly, Paul S

“…Radionuclide therapy targeting prostate-specific membrane antigen (PSMA) is promising for prostate cancer. We previously reported a ligand, 64Cu-CuSarbisPSMA,…”
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Therapeutic Efficacy of a Bivalent Inhibitor of Prostate-Specific Membrane Antigen Labeled with 67 Cu by McInnes, Lachlan E, Cullinane, Carleen, Roselt, Peter D, Jackson, Susan, Blyth, Benjamin J, van Dam, Ellen M, Zia, Nicholas A, Harris, Matthew J, Hicks, Rodney J, Donnelly, Paul S

“…Radionuclide therapy targeting prostate-specific membrane antigen (PSMA) is promising for prostate cancer. We previously reported a ligand, Cu-CuSarbisPSMA,…”
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Imaging Somatostatin Positive Tumors with Tyr 3 -Octreotate/Octreotide Conjugated to Desferrioxamine B Squaramide Radiolabeled with either Zirconium-89 or Gallium-68 by Noor, Asif, Van Zuylekom, Jessica K, Rudd, Stacey E, Roselt, Peter D, Haskali, Mohammad B, Yan, Eddie, Wheatcroft, Michael, Hicks, Rodney J, Cullinane, Carleen, Donnelly, Paul S

“…Radiolabeled derivatives of Tyr -octreotide and Tyr -octreotate, synthetic analogues of the peptide hormone somatostatin, can be used for positron emission…”
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4-Nitrophenyl activated esters are superior synthons for indirect radiofluorination of biomolecules by Haskali, Mohammad B, Farnsworth, Ashleigh L, Roselt, Peter D, Hutton, Craig A

“…Indirect radiolabelling has for a long time been the mainstay strategy for radiofluorination of biomolecules. Acylation of biomolecules through the use of an…”
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Peptide Receptor Radionuclide Therapy with 67 Cu-CuSarTATE Is Highly Efficacious Against a Somatostatin-Positive Neuroendocrine Tumor Model by Cullinane, Carleen, Jeffery, Charmaine M, Roselt, Peter D, van Dam, Ellen M, Jackson, Susan, Kuan, Kevin, Jackson, Price, Binns, David, van Zuylekom, Jessica, Harris, Matthew J, Hicks, Rodney J, Donnelly, Paul S

“…Peptide receptor radionuclide therapy (PRRT) using radiolabeled octreotate is an effective treatment for somatostatin receptor 2-expressing neuroendocrine…”
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A Copper Complex of a Thiosemicarbazone-Pyridylhydrazone Ligand Containing a Vinylpyridine Functional Group as a Potential Imaging Agent for Amyloid-β Plaques by McInnes, Lachlan E, Noor, Asif, Roselt, Peter D, McLean, Catriona A, White, Jonathan M, Donnelly, Paul S

“…Complexes containing positron-emitting radionuclides of copper have the potential to be of use for diagnostic imaging with positron emission tomography…”
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Radiosynthesis and preliminary in vivo evaluation of 18F-labelled glycosylated duramycin peptides for imaging of phosphatidylethanolamine during apoptosis by Haskali, Mohammad B, Denoyer, Delphine, Roselt, Peter D, Hicks, Rodney J, Hutton, Craig A

“…Duramycin derivatives incorporating an [18F]-labelled prosthetic group and one or two hydrophilic sugar amino acid moieties have been prepared as potential…”
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