Search Results - "Rose, Rachel H."

Potential Sources of Inter-Subject Variability in Monoclonal Antibody Pharmacokinetics by Gill, Katherine L., Machavaram, Krishna K., Rose, Rachel H., Chetty, Manoranjenni

“…Understanding inter-subject variability in drug pharmacokinetics and pharmacodynamics is important to ensure that all patients attain suitable drug exposure to…”
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Application of physiologically based pharmacokinetic models for therapeutic proteins and other novel modalities by Rose, Rachel H., Sepp, Armin, Stader, Felix, Gill, Katherine L., Liu, Cong, Gardner, Iain

“…The past two decades have seen diversification of drug development pipelines and approvals from traditional small molecule therapies to alternative modalities…”
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A novel fluorescent histamine H1 receptor antagonist demonstrates the advantage of using fluorescence correlation spectroscopy to study the binding of lipophilic ligands by Rose, Rachel H, Briddon, Stephen J, Hill, Stephen J

“…BACKGROUND AND PURPOSE Fluorescent ligands facilitate the study of ligand–receptor interactions at the level of single cells and individual receptors. Here, we…”
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Quantitative systems pharmacology‐based exploration of relevant anti‐amyloid therapy challenges in clinical practice by Geerts, Hugo, Bergeler, Silke, Walker, Mike, Rose, Rachel H., Graaf, Piet H.

“…INTRODUCTION Addressing practical challenges in clinical practice after the recent approvals of amyloid antibodies in Alzheimer's disease (AD) will benefit…”
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Learn–confirm in model‐informed drug development: Assessing an immunogenicity quantitative systems pharmacology platform by Franssen, Linnea C., Swat, Maciej J., Kierzek, Andrzej M., Rose, Rachel H., Graaf, Piet H., Grimm, Hans Peter

“…Immunogenicity against therapeutic proteins frequently causes attrition owing to its potential impact on pharmacokinetics, pharmacodynamics, efficacy, and…”
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Pharmacokinetics, Pharmacodynamics and Physiologically-Based Pharmacokinetic Modelling of Monoclonal Antibodies by Dostalek, Miroslav, Gardner, Iain, Gurbaxani, Brian M., Rose, Rachel H., Chetty, Manoranjenni

“…Development of monoclonal antibodies (mAbs) and their functional derivatives represents a growing segment of the development pipeline in the pharmaceutical…”
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Physiologically-based pharmacokinetic modeling to predict drug-drug interaction of enzalutamide with combined P-gp and CYP3A substrates by Otsuka, Yukio, Poondru, Srinivasu, Bonate, Peter L., Rose, Rachel H., Jamei, Masoud, Ushigome, Fumihiko, Minematsu, Tsuyoshi

“…Enzalutamide is known to strongly induce cytochrome P450 3A4 (CYP3A4). Furthermore, enzalutamide showed induction and inhibition of P-glycoprotein (P-gp) in in…”
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Incorporation of the Time-Varying Postprandial Increase in Splanchnic Blood Flow into a PBPK Model to Predict the Effect of Food on the Pharmacokinetics of Orally Administered High-Extraction Drugs by Rose, Rachel H., Turner, David B., Neuhoff, Sibylle, Jamei, Masoud

“…ABSTRACT Following a meal, a transient increase in splanchnic blood flow occurs that can result in increased exposure to orally administered high-extraction…”
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The use of PBPK/PD to establish clinically relevant dissolution specifications for zolpidem immediate release tablets by Paraiso, Rafael L.M., Rose, Rachel H., Fotaki, Nikoletta, McAllister, Mark, Dressman, Jennifer B.

“…Zolpidem is a non-benzodiazepine hypnotic agent which has been shown to be effective in inducing and maintaining sleep in adults and is one of the most…”
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A novel fluorescent histamine H 1 receptor antagonist demonstrates the advantage of using fluorescence correlation spectroscopy to study the binding of lipophilic ligands by Rose, Rachel H, Briddon, Stephen J, Hill, Stephen J

“…BACKGROUND AND PURPOSE Fluorescent ligands facilitate the study of ligand–receptor interactions at the level of single cells and individual receptors. Here, we…”
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Bimolecular fluorescence complementation: lighting up seven transmembrane domain receptor signalling networks by Rose, Rachel H, Briddon, Stephen J, Holliday, Nicholas D

“…There is increasing complexity in the organization of seven transmembrane domain (7TM) receptor signalling pathways, and in the ability of their ligands to…”
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Applications of linking PBPK and PD models to predict the impact of genotypic variability, formulation differences, differences in target binding capacity and target site drug concentrations on drug responses and variability by Chetty, Manoranjenni, Rose, Rachel H, Abduljalil, Khaled, Patel, Nikunjkumar, Lu, Gaohua, Cain, Theresa, Jamei, Masoud, Rostami-Hodjegan, Amin

“…This study aimed to demonstrate the added value of integrating prior in vitro data and knowledge-rich physiologically based pharmacokinetic (PBPK) models with…”
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Abstract 2952: Predicting concentration of PARP inhibitors in human tumor tissue using PBPK modeling by Rose, Rachel H., Sun, Kaiming, Li, Linzhong, Gada, Keyur, Wang, Jing Yu, Qiu, Yongchang

“…Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors exert their effect intracellularly within tumor, thus sufficient tumor penetration is essential for a…”
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A novel fluorescent histamine H, receptor antagonist demonstrates the advantage of using fluorescence correlation spectroscopy to study the binding of lipophilic ligands by ROSE, Rachel H, BRIDDON, Stephen J, HILL, Stephen J

“…Fluorescent ligands facilitate the study of ligand-receptor interactions at the level of single cells and individual receptors. Here, we describe a novel…”
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The Effect of Agonist Activation and Homodimerisation on the Membrane Diffusion of the Human Histamine H1 Receptor by Rose, Rachel H., Briddon, Stephen J., Hill, Stephen J.

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