Search Results - "Rose, Mark J."

Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans by Gavva, Narender R., Treanor, James J.S., Garami, Andras, Fang, Liang, Surapaneni, Sekhar, Akrami, Anna, Alvarez, Francisco, Bak, Annette, Darling, Mary, Gore, Anu, Jang, Graham R., Kesslak, James P., Ni, Liyun, Norman, Mark H., Palluconi, Gabrielle, Rose, Mark J., Salfi, Margaret, Tan, Edward, Romanovsky, Andrej A., Banfield, Christopher, Davar, Gudarz

“…The vanilloid receptor TRPV1 has been identified as a molecular target for the treatment of pain associated with inflammatory diseases and cancer. Hence, TRPV1…”
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Heparanase induces inflammatory cell recruitment in vivo by promoting adhesion to vascular endothelium by Lever, Rebecca, Rose, Mark J, McKenzie, Edward A, Page, Clive P

“…Heparanase (HPSE1) is known to be involved in mechanisms of metastatic tumor cell migration. This enzyme selectively cleaves heparan sulfate proteoglycans…”
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Pharmacokinetics of Anti-hepcidin Monoclonal Antibody Ab 12B9m and Hepcidin in Cynomolgus Monkeys by Xiao, Jim J., Krzyzanski, Wojciech, Wang, Yow-Ming, Li, Hongyan, Rose, Mark J., Ma, Mark, Wu, Yuling, Hinkle, Beth, Perez-Ruixo, Juan Jose

“…Hepcidin is a key regulator responsible for systemic iron homeostasis. A semi-mechanistic PK model for hepcidin and a fully human anti-hepcidin monoclonal…”
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Selective and potent Raf inhibitors paradoxically stimulate normal cell proliferation and tumor growth by Carnahan, Josette, Beltran, Pedro J, Babij, Carol, Le, Quynh, Rose, Mark J, Vonderfecht, Steven, Kim, Joseph L, Smith, Adrian L, Nagapudi, Karthik, Broome, Martin A, Fernando, Manory, Kha, Hue, Belmontes, Brian, Radinsky, Robert, Kendall, Richard, Burgess, Teresa L

“…Raf inhibitors are under clinical investigation, specifically in patients with tumor types harboring frequent activating mutations in B-Raf. Here, we show that…”
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Development of a method for the sensitive and quantitative determination of hepcidin in human serum using LC-MS/MS by Li, Hongyan, Rose, Mark J., Tran, Linh, Zhang, Jingwen, Miranda, Les P., James, Christopher A., Sasu, Barbra J.

“…Hepcidin, a 25-amino acid peptide hormone, plays a crucial regulatory role in iron metabolism. Elevated hepcidin has been observed in response to inflammation…”
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Quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays by Viswanathan, C T, Bansal, Surendra, Booth, Brian, DeStefano, Anthony J, Rose, Mark J, Sailstad, Jeffrey, Shah, Vinod P, Skelly, Jerome P, Swann, Patrick G, Weiner, Russell

“…The Third AAPS/FDA Bioanalytical Workshop, entitled "Quantitative Bioanalytical Methods Validation and Implementation: Best Practices for Chromatographic and…”
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EVALUATION OF MICRODOSING STRATEGIES FOR STUDIES IN PRECLINICAL DRUG DEVELOPMENT: DEMONSTRATION OF LINEAR PHARMACOKINETICS IN DOGS OF A NUCLEOSIDE ANALOG OVER A 50-FOLD DOSE RANGE by SANDHU, Punam, VOGEL, John S, BAILLIE, Thomas A, ROSE, Mark J, UBICK, Esther A, BRUNNER, Janice E, WALLACE, Michael A, ADELSBERGER, Jennifer K, BAKER, Maribeth P, HENDERSON, Paul T, PEARSON, Paul G

“…The technique of accelerator mass spectrometry (AMS) was validated successfully and used to study the pharmacokinetics and disposition in dogs of a preclinical…”
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Concerns in the development of an assay for determination of a highly conjugated adsorption-prone compound in human urine by YANG XU, LIHONG DU, ROSE, Mark J, IRONG FU, WOOLF, Eric J, MUSSON, Donald G

“…Concerns in pre-analytical handling of urine samples are discussed using a new KDR kinase inhibitor,…”
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Selective Inhibitors of the Mutant B-Raf Pathway: Discovery of a Potent and Orally Bioavailable Aminoisoquinoline by Smith, Adrian L, DeMorin, Frenel F, Paras, Nick A, Huang, Qi, Petkus, Jeffrey K, Doherty, Elizabeth M, Nixey, Thomas, Kim, Joseph L, Whittington, Douglas A, Epstein, Linda F, Lee, Matthew R, Rose, Mark J, Babij, Carol, Fernando, Manory, Hess, Kristen, Le, Quynh, Beltran, Pedro, Carnahan, Josette

“…The discovery and optimization of a novel series of aminoisoquinolines as potent, selective, and efficacious inhibitors of the mutant B-Raf pathway is…”
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Design and Synthesis of Conformationally Constrained Glucagon-Like Peptide-1 Derivatives with Increased Plasma Stability and Prolonged in Vivo Activity by Miranda, Les P, Winters, Katherine A, Gegg, Colin V, Patel, Ankita, Aral, Jennifer, Long, Jason, Zhang, Jingwen, Diamond, Stephanie, Guido, Mark, Stanislaus, Shanaka, Ma, Mark, Li, Hongyan, Rose, Mark J, Poppe, Leszek, Véniant, Murielle M

“…A series of conformationally constrained derivatives of glucagon-like peptide-1 (GLP-1) were designed and evaluated. By use of [Gly8]GLP-1(7–37)-NH2 (2)…”
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Serum hepcidin but not prohepcidin may be an effective marker for anemia of inflammation (AI) by Sasu, Barbra J., Li, Hongyan, Rose, Mark J., Arvedson, Tara L., Doellgast, George, Molineux, Graham

“…Anemia in cancer patients can result from a complex interaction of numerous factors including iron deficiency, inflammation, toxicity related to therapy and…”
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Validation of a method for the determination of AMG 579 in cerebrospinal fluid with a focus on sample collection procedures for clinical trials by Wilson, Sarah F., Kerr, Savannah J., Rose, Mark J., James, Christopher A.

“…•Molecules can non-specifically bind to surfaces thus reducing their recovery in low protein matrices such as CSF.•When sampling CSF in the clinic, potential…”
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Development of a method for the determination of glycine in human cerebrospinal fluid using pre-column derivatization and LC–MS/MS by Wilson, Sarah F., James, Christopher A., Zhu, Xiaochun, Davis, Mike T., Rose, Mark J.

“…An LC–MS/MS method using pre-column derivatization with phenylisothiocyanate (PITC) was developed to quantify glycine in human cerebrospinal fluid (CSF) and…”
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Bioanalytical Method Validation: Concepts, Expectations and Challenges in Small Molecule and Macromolecule—A Report of PITTCON 2013 Symposium by Bashaw, Edward D., DeSilva, Binodh, Rose, Mark J., Wang, Yow-Ming C., Shukla, Chinmay

“…The concepts, importance, and implications of bioanalytical method validation has been discussed and debated for a long time. The recent high profile issues…”
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Direct Quantitative Analysis of a 20 kDa PEGylated Human Calcitonin Gene Peptide Antagonist in Cynomolgus Monkey Serum Using In-Source CID and UPLC-MS/MS by Li, Hongyan, Rose, Mark J., Holder, Jerry Ryan, Wright, Marie, Miranda, Les P., James, Christopher A.

“…PEGylation is a successful strategy to improve the pharmacokinetic and pharmaceutical properties of therapeutic peptides. However, quantitative analysis of…”
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Platelets are essential for leukocyte recruitment in allergic inflammation by Pitchford, Simon C., Yano, Hiroshi, Lever, Rebecca, Riffo-Vasquez, Yanira, Ciferri, Silvia, Rose, Mark J., Giannini, Silvia, Momi, Stefania, Spina, Domenico, O'Connor, Brian, Gresele, Paolo, Page, Clive P.

“…Background: The role of platelets in inflammation is recognized but poorly characterized, and little is known of their interaction with leukocytes. However,…”
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Single- and Multiple-Dose Pharmacokinetics of Etoricoxib, a Selective Inhibitor of Cyclooxygenase-2, in Man by Agrawal, Nancy G. B., Porras, Arturo G., Matthews, Catherine Z., Rose, Mark J., Woolf, Eric J., Musser, Bret J., Dynder, Andrea L., Mazina, Katherine E., Lasseter, Kenneth C., Hunt, Thomas L., Schwartz, Jules I., McCrea, Jacqueline B., Gottesdiener, Keith M.

“…The single‐ and multiple‐dose pharmacokinetics of etoricoxib, a selective inhibitor of cyclooxygenase‐2, were examined in two clinical studies. Single‐dose…”
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Amino acid and peptide analysis using derivatization with p-nitrophenol-2,5-dihydroxyphenylacetate bis-tetrahydropyranyl ether and capillary electrophoresis with electrochemical detection by Rose, Mark J, Lunte, Susan M, Carlson, Robert G, Stobaugh, John F

“…The amine derivatization reagent p-nitrophenol-2,5-dihydroxyphenylacetate bis-tetrahydropyranyl ether (NDTE) was used in conjunction with capillary…”
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Determination of potato carboxypeptidase inhibitor in African Green Monkey plasma using 96-well SPE and LC–MS/MS by Rose, Mark J., Fernandez-Metzler, Carmen, Johns, Brett A., Sitko, Gary R., Cook, Jacquelynn J., Yergey, James

“…Potato carboxypeptidase inhibitor (CPI), a peptide with multiple isoforms (MW > 4000 Da) was determined from African Green Monkey plasma using a PE Sciex…”
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Pharmacokinetics of Etoricoxib in Patients with Hepatic Impairment by Agrawal, Nancy G. B., Rose, Mark J., Matthews, Catherine Z., Woolf, Eric J., Porras, Arturo G., Geer, Leslie A., Larson, Patrick J., Cote, Josee, Dilzer, Stacy C., Lasseter, Kenneth C., Alam, Imtiaz, Petty, Kevin J., Gottesdiener, Keith M.

“…The effect of hepatic insufficiency on the pharmacokinetics of etoricoxib, a selective inhibitor of cyclooxygenase‐2, was investigated following administration…”
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