Search Results - "Rose, Lynda"

Percent reduction in LDL cholesterol following high-intensity statin therapy: potential implications for guidelines and for the prescription of emerging lipid-lowering agents by Ridker, Paul M, Mora, Samia, Rose, Lynda

“…Current statin guidelines in Europe and Canada advocate achieving a fixed LDL target or the attainment of a ≥50% reduction in low-density lipoprotein…”
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Residual Inflammatory Risk on Treatment With PCSK9 Inhibition and Statin Therapy by Pradhan, Aruna D, Aday, Aaron W, Rose, Lynda M, Ridker, Paul M

“…BACKGROUND:The combination of statin therapy and PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibition markedly lowers low-density lipoprotein…”
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The neutrophil-lymphocyte ratio and incident atherosclerotic events: analyses from five contemporary randomized trials by Adamstein, Nicholas H, MacFadyen, Jean G, Rose, Lynda M, Glynn, Robert J, Dey, Amit K, Libby, Peter, Tabas, Ira A, Mehta, Nehal N, Ridker, Paul M

“…The neutrophil-lymphocyte ratio (NLR) is a readily available inflammatory biomarker that may associate with atherosclerosis and predict cardiovascular (CV)…”
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Plasma proprotein convertase subtilisin/kexin type 9 levels and the risk of first cardiovascular events by Ridker, Paul M, Rifai, Nader, Bradwin, Gary, Rose, Lynda

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that enhances degradation of the LDL receptor. While agents that inhibit PCSK9…”
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Lipid-Reduction Variability and Antidrug-Antibody Formation with Bococizumab by Ridker, Paul M, Tardif, Jean-Claude, Amarenco, Pierre, Duggan, William, Glynn, Robert J, Jukema, J. Wouter, Kastelein, John J.P, Kim, Albert M, Koenig, Wolfgang, Nissen, Steven, Revkin, James, Rose, Lynda M, Santos, Raul D, Schwartz, Pamela F, Shear, Charles L, Yunis, Carla

“…In six trials comparing the anti–PCSK9 antibody bococizumab with placebo, the reduction in LDL cholesterol at 12 weeks was 55.2 percentage points lower with…”
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Physical and neurobehavioral determinants of reproductive onset and success by Day, Felix R, Helgason, Hannes, Chasman, Daniel I, Rose, Lynda M, Loh, Po-Ru, Scott, Robert A, Helgason, Agnar, Kong, Augustine, Masson, Gisli, Magnusson, Olafur Th, Gudbjartsson, Daniel, Thorsteinsdottir, Unnur, Buring, Julie E, Ridker, Paul M, Sulem, Patrick, Stefansson, Kari, Ong, Ken K, Perry, John R B

“…John Perry, Ken Ong and colleagues perform a genome-wide association study for reproductive ability, behavior and success to determine underlying genetic…”
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C-Reactive Protein Levels and Outcomes after Statin Therapy by Ridker, Paul M, Cannon, Christopher P, Morrow, David, Rifai, Nader, Rose, Lynda M, McCabe, Carolyn H, Pfeffer, Marc A, Braunwald, Eugene

“…Statin therapy lowers not only low-density lipoprotein (LDL) cholesterol levels, but also levels of C-reactive protein (CRP), a marker of inflammation. This…”
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Genetic Obesity and the Risk of Atrial Fibrillation: Causal Estimates from Mendelian Randomization by Chatterjee, Neal A, Giulianini, Franco, Geelhoed, Bastiaan, Lunetta, Kathryn L, Misialek, Jeffrey R, Niemeijer, Maartje N, Rienstra, Michiel, Rose, Lynda M, Smith, Albert V, Arking, Dan E, Ellinor, Patrick T, Heeringa, Jan, Lin, Honghuang, Lubitz, Steven A, Soliman, Elsayed Z, Verweij, Niek, Alonso, Alvaro, Benjamin, Emelia J, Gudnason, Vilmundur, Stricker, Bruno H C, Van Der Harst, Pim, Chasman, Daniel I, Albert, Christine M

“…BACKGROUND:Observational studies have identified an association between body mass index (BMI) and incident atrial fibrillation (AF). Inferring causality from…”
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Novel locus including FGF21 is associated with dietary macronutrient intake by Chu, Audrey Y, Workalemahu, Tsegaselassie, Paynter, Nina P, Rose, Lynda M, Giulianini, Franco, Tanaka, Toshiko, Ngwa, Julius S, Qi, Qibin, Curhan, Gary C, Rimm, Eric B, Hunter, David J, Pasquale, Louis R, Ridker, Paul M, Hu, Frank B, Chasman, Daniel I, Qi, Lu

“…Dietary intake of macronutrients (carbohydrate, protein, and fat) has been associated with risk of chronic conditions such as obesity and diabetes. Family…”
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Comparison of C-Reactive Protein and Low-Density Lipoprotein Cholesterol Levels in the Prediction of First Cardiovascular Events by Ridker, Paul M, Rifai, Nader, Rose, Lynda, Buring, Julie E, Cook, Nancy R

“…Studies have suggested that C-reactive protein, a marker of inflammation, may predict the risk of cardiovascular events, including coronary events. In this…”
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Relative efficacy of atorvastatin 80 mg and pravastatin 40 mg in achieving the dual goals of low-density lipoprotein cholesterol <70 mg/dl and c-reactive protein <2 mg/l : An analysis of the PROVE-IT TIMI-22 trial by RIDKER, Paul M, MORROW, David A, ROSE, Lynda M, RIFAI, Nader, CANNON, Christopher P, BRAUNWALD, Eugene

“…The aim of this research was to compare relative efficacy of different statin regimens in achieving the dual goals of low-density lipoprotein cholesterol…”
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Cardiovascular event reduction with PCSK9 inhibition among 1578 patients with familial hypercholesterolemia: Results from the SPIRE randomized trials of bococizumab by Ridker, Paul M, Rose, Lynda M., Kastelein, John J.P., Santos, Raul D., Wei, Caimiao, Revkin, James, Yunis, Carla, Tardif, Jean-Claude, Shear, Charles L.

“…Familial hypercholesterolemia (FH) is a dominant genetic disorder associated with elevated low-density lipoprotein cholesterol (LDL-C) and premature…”
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A genome-wide association study of early menopause and the combined impact of identified variants by Perry, John R B, Corre, Tanguy, Esko, Tõnu, Chasman, Daniel I, Fischer, Krista, Franceschini, Nora, He, Chunyan, Kutalik, Zoltan, Mangino, Massimo, Rose, Lynda M, Vernon Smith, Albert, Stolk, Lisette, Sulem, Patrick, Weedon, Michael N, Zhuang, Wei V, Arnold, Alice, Ashworth, Alan, Bergmann, Sven, Buring, Julie E, Burri, Andrea, Chen, Constance, Cornelis, Marilyn C, Couper, David J, Goodarzi, Mark O, Gudnason, Vilmundur, Harris, Tamara, Hofman, Albert, Jones, Michael, Kraft, Peter, Launer, Lenore, Laven, Joop S E, Li, Guo, McKnight, Barbara, Masciullo, Corrado, Milani, Lili, Orr, Nicholas, Psaty, Bruce M, Ridker, Paul M, Rivadeneira, Fernando, Sala, Cinzia, Salumets, Andres, Schoemaker, Minouk, Traglia, Michela, Waeber, Gérard, Chanock, Stephen J, Demerath, Ellen W, Garcia, Melissa, Hankinson, Susan E, Hu, Frank B, Hunter, David J, Lunetta, Kathryn L, Metspalu, Andres, Montgomery, Grant W, Murabito, Joanne M, Newman, Anne B, Ong, Ken K, Spector, Tim D, Stefansson, Kari, Swerdlow, Anthony J, Thorsteinsdottir, Unnur, Van Dam, Rob M, Uitterlinden, André G, Visser, Jenny A, Vollenweider, Peter, Toniolo, Daniela, Murray, Anna

“…Early menopause (EM) affects up to 10% of the female population, reducing reproductive lifespan considerably. Currently, it constitutes the leading cause of…”
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A Proposal to Incorporate Trial Data Into a Hybrid ACC/AHA Algorithm for the Allocation of Statin Therapy in Primary Prevention by Ridker, Paul M, MD, MPH, Rose, Lynda, BS, Cook, Nancy R., ScD

“…Abstract Current algorithms for statin allocation in primary prevention use epidemiologic estimates of absolute risk. However, a global risk prediction score…”
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Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation: The AFGen Consortium by Norby, Faye L, Eryd, Samuel Adamsson, Niemeijer, Maartje N, Rose, Lynda M, Smith, Albert V, Yin, Xiaoyan, Agarwal, Sunil K, Arking, Dan E, Chasman, Daniel L, Chen, Lin Y, Eijgelsheim, Mark, Engström, Gunnar, Franco, Oscar H, Heeringa, Jan, Hindy, George, Hofman, Albert, Lutsey, Pamela L, Magnani, Jared W, McManus, David D, Orho-Melander, Marju, Pankow, James S, Rukh, Gull, Schulz, Christina-Alexandra, Uitterlinden, André G, Albert, Christine M, Benjamin, Emelia J, Gudnason, Vilmundur, Smith, J Gustav, Stricker, Bruno H C, Alonso, Alvaro

“…Several studies have shown associations between blood lipid levels and the risk of atrial fibrillation (AF). To test the potential effect of blood lipids with…”
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Fried food consumption, genetic risk, and body mass index: gene-diet interaction analysis in three US cohort studies by Qi, Qibin, Chu, Audrey Y, Kang, Jae H, Huang, Jinyan, Rose, Lynda M, Jensen, Majken K, Liang, Liming, Curhan, Gary C, Pasquale, Louis R, Wiggs, Janey L, De Vivo, Immaculata, Chan, Andrew T, Choi, Hyon K, Tamimi, Rulla M, Ridker, Paul M, Hunter, David J, Willett, Walter C, Rimm, Eric B, Chasman, Daniel I, Hu, Frank B, Qi, Lu

“…Objective To examine the interactions between genetic predisposition and consumption of fried food in relation to body mass index (BMI) and obesity.Design…”
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Rationale, Design, and Methodology of the Women's Genome Health Study: A Genome-Wide Association Study of More Than 25 000 Initially Healthy American Women by Ridker, Paul M, Chasman, Daniel I, Zee, Robert Y.L, Parker, Alex, Rose, Lynda, Cook, Nancy R, Buring, Julie E, Women's Genome Health Study Working Group

“…The primary aim of the Women's Genome Health Study (WGHS) is to create a comprehensive, fully searchable genome-wide database of >360 000 single nucleotide…”
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Using genetics to test the causal relationship of total adiposity and periodontitis: Mendelian randomization analyses in the Gene-Lifestyle Interactions and Dental Endpoints (GLIDE) Consortium by Shungin, Dmitry, Cornelis, Marilyn C, Divaris, Kimon, Holtfreter, Birte, Shaffer, John R, Yu, Yau-Hua, Barros, Silvana P, Beck, James D, Biffar, Reiner, Boerwinkle, Eric A, Crout, Richard J, Ganna, Andrea, Hallmans, Goran, Hindy, George, Hu, Frank B, Kraft, Peter, McNeil, Daniel W, Melander, Olle, Moss, Kevin L, North, Kari E, Orho-Melander, Marju, Pedersen, Nancy L, Ridker, Paul M, Rimm, Eric B, Rose, Lynda M, Rukh, Gull, Teumer, Alexander, Weyant, Robert J, Chasman, Daniel I, Joshipura, Kaumudi, Kocher, Thomas, Magnusson, Patrik K E, Marazita, Mary L, Nilsson, Peter, Offenbacher, Steve, Davey Smith, George, Lundberg, Pernilla, Palmer, Tom M, Timpson, Nicholas J, Johansson, Ingegerd, Franks, Paul W

“…The observational relationship between obesity and periodontitis is widely known, yet causal evidence is lacking. Our objective was to investigate causal…”
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Prospective study of sudden cardiac death among women in the United States by ALBERT, Christine M, CHAE, Claudia U, GRODSTEIN, Francine, ROSE, Lynda M, REXRODE, Kathryn M, RUSKIN, Jeremy N, STAMPFER, Meir J, MANSON, Joann E

“…There are few data regarding the determinants of sudden cardiac death (SCD) in women, primarily because of their markedly lower rate of SCD compared with men…”
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Plasma Levels of the Proinflammatory Chitin‐Binding Glycoprotein YKL‐40, Variation in the Chitinase 3‐Like 1 Gene (CHI3L1), and Incident Cardiovascular Events by Ridker, Paul M, Chasman, Daniel I., Rose, Lynda, Loscalzo, Joseph, Elias, Jack A.

“…Background YKL‐40, encoded by the chitinase 3‐like 1 (CHI3L1) gene, is a chitinase‐like protein involved in innate immune function hypothesized to play a role…”
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