Search Results - "Rose, Jack W."

Identification of Orally Active, Potent, and Selective 4-Piperazinylquinazolines as Antagonists of the Platelet-Derived Growth Factor Receptor Tyrosine Kinase Family by Pandey, Anjali, Volkots, Deborah L, Seroogy, Joseph M, Rose, Jack W, Yu, Jin-Chen, Lambing, Joseph L, Hutchaleelaha, Athiwat, Hollenbach, Stanley J, Abe, Keith, Giese, Neill A, Scarborough, Robert M

“…We have previously found that the 4-[4-(N-substituted carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazolines can function as potent and selective inhibitors of…”
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Discovery of Novel 2,8-Diazaspiro[4.5]decanes as Orally Active Glycoprotein IIb-IIIa Antagonists by Mehrotra, Mukund M., Heath, Julie A., Smyth, Mark S., Pandey, Anjali, Rose, Jack W., Seroogy, Joseph M., Volkots, Deborah L., Nannizzi-Alaimo, Lisa, Park, Gary L., Lambing, Joseph L., Hollenbach, Stanley J., Scarborough, Robert M.

“…In our efforts to develop orally active GPIIb-IIIa antagonists with improved pharmaceutical properties, we have utilized a novel 2,8-diazaspiro[4.5]decane…”
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Binding of a Novel 50-kilodalton Alboaggregin from Trimeresurus albolabris and Related Viper Venom Proteins to the Platelet Membrane Glycoprotein Ib-IX-V Complex. Effect on Platelet Aggregation and Glycoprotein Ib-Mediated Platelet Activation by Andrews, Robert K, Kroll, Michael H, Ward, Christopher M, Rose, Jack W, Scarborough, Robert M, Smith, A. Ian, López, José A, Berndt, Michael C

“…Binding of the multimeric adhesive glycoprotein, von Willebrand Factor (vWF), to the platelet membrane glycoprotein (GP) Ib-IX-V complex mediates platelet…”
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Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 3: Synthesis and SAR of potent and specific 2,8-diazaspiro[4.5]decanes by MEHROTRA, Mukund M, HEATH, Julie A, PANDEY, Anjali, SCARBOROUGH, Robert M, ROSE, Jack W, SMYTH, Mark S, SEROOGY, Joseph, VOLKOTS, Deborah L, RUHTER, Gerd, SCHOTTEN, Theo, ALAIMO, Lisa, PARK, Gary

“…The synthesis and biological activity of analogues containing spiro piperidinylpyridine and pyrrolidinylpyridine templates are described. The potent activity…”
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Fibrinogen Receptor (GPIIb-IIIa) Antagonists Derived from 5,6-Bicyclic Templates. Amidinoindoles, Amidinoindazoles, and Amidinobenzofurans Containing the N-α-Sulfonamide Carboxylic Acid Function as Potent Platelet Aggregation Inhibitors by Su, Ting, Naughton, Mary Ann H, Smyth, Mark S, Rose, Jack W, Arfsten, Ann E, McCowan, Jefferson R, Jakubowski, Joseph A, Wyss, Virginia L, Ruterbories, Kenneth J, Sall, Daniel J, Scarborough, Robert M

“…A series of highly potent and specific fibrinogen receptor antagonists have been discovered and optimized through structural modification of the novel…”
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Use of Conformationally Restricted Benzamidines as Arginine Surrogates in the Design of Platelet GPIIb-IIIa Receptor Antagonists by Sall, Daniel J, Arfsten, Ann E, Bastian, Jolie A, Denney, Michael L, Harms, Cathy S, McCowan, Jefferson R, Morin, John M, Rose, Jack W, Scarborough, Robert M, Smyth, Mark S, Um, Suzane L, Utterback, Barbara G, Vasileff, Robert T, Wikel, James H, Wyss, Virginia L, Jakubowski, Joseph A

“…The use of 5,6-bicyclic amidines as arginine surrogates in the design of a novel class of potent platelet glycoprotein IIb-IIIa receptor (GPIIb-IIIa)…”
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Design of potent and specific integrin antagonists. Peptide antagonists with high specificity for glycoprotein IIb-IIIa by SCARBOROUGH, R. M, NAUGHTON, M. A, TENG, W, ROSE, J. W, PHILLIPS, D. R, NANNIZZI, L, ARFSTEN, A, CAMPBELL, A. M, CHARO, I. F

“…Members of the snake venon-derived, "disintegrin" peptide family containing the Arg-Gly-Asp (RGD) amino acid sequence are among the most potent inhibitors of…”
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Characterization of the integrin specificities of disintegrins isolated from American pit viper venoms by SCARBOROUGH, R. M, ROSE, J. W, NAUGHTON, M. A, PHILLIPS, D. R, NANNIZZI, L, ARFSTEN, A, CAMPBELL, A. M, CHARO, I. F

“…A new series of homologous disintegrins was isolated from the venoms of new world pit viper genus Bothrops, Crotalus, and Lachesis. The relative activities of…”
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Barbourin. A GPIIb-IIIa-specific integrin antagonist from the venom of Sistrurus m. barbouri by SCARBOROUGH, R. M, ROSE, J. W, HSU, M. A, PHILLIPS, D. R, FRIED, V. A, CAMPBELL, A. M, NANNIZZI, L, CHARO, I. F

“…Sixty-two snake venoms were screened to identify those which specifically inhibit the adhesive protein binding function of the glycoprotein (GP) IIb-IIIa…”
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Angular Distribution of Photons in Showers in Lead by Rose, Jack W.

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