Search Results - "Roschke, V"

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease by Yun, Seung Pil, Kam, Tae-In, Panicker, Nikhil, Kim, SangMin, Oh, Yumin, Park, Jong-Sung, Kwon, Seung-Hwan, Park, Yong Joo, Karuppagounder, Senthilkumar S., Park, Hyejin, Kim, Sangjune, Oh, Nayeon, Kim, Nayoung Alice, Lee, Saebom, Brahmachari, Saurav, Mao, Xiaobo, Lee, Jun Hee, Kumar, Manoj, An, Daniel, Kang, Sung-Ung, Lee, Yunjong, Lee, Kang Choon, Na, Dong Hee, Kim, Donghoon, Lee, Sang Hun, Roschke, Viktor V., Liddelow, Shane A., Mari, Zoltan, Barres, Ben A., Dawson, Valina L., Lee, Seulki, Dawson, Ted M., Ko, Han Seok

“…Activation of microglia by classical inflammatory mediators can convert astrocytes into a neurotoxic A1 phenotype in a variety of neurological diseases 1 , 2 …”
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Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma by Affer, M, Chesi, M, Chen, W D, Keats, J J, Demchenko, Y N, Tamizhmani, K, Garbitt, V M, Riggs, D L, Brents, L A, Roschke, A V, Van Wier, S, Fonseca, R, Bergsagel, P L, Kuehl, W M

“…MYC locus rearrangements—often complex combinations of translocations, insertions, deletions and inversions—in multiple myeloma (MM) were thought to be a late…”
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Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma by Park, Jong-Sung, Oh, Yumin, Park, Yong Joo, Park, Ogyi, Yang, Hoseong, Slania, Stephanie, Hummers, Laura K., Shah, Ami A., An, Hyoung-Tae, Jang, Jiyeon, Horton, Maureen R., Shin, Joseph, Dietz, Harry C., Song, Eric, Na, Dong Hee, Park, Eun Ji, Kim, Kwangmeyung, Lee, Kang Choon, Roschke, Viktor V., Hanes, Justin, Pomper, Martin G., Lee, Seulki

“…Scleroderma is an autoimmune rheumatic disorder accompanied by severe fibrosis in skin and other internal organs. During scleroderma progression, resident…”
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Targeting karyotypic complexity and chromosomal instability of cancer cells by Roschke, Anna V, Kirsch, Ilan R

“…Multiple karyotypic abnormalities and chromosomal instability are characteristic features of many cancers that are relatively resistant to chemotherapeutic…”
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Multi-layered cancer chromosomal instability phenotype by Roschke, Anna V, Rozenblum, Ester

“…Whole-chromosomal instability (W-CIN) - unequal chromosome distribution during cell division - is a characteristic feature of a majority of cancer cells…”
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Aberrant immunoglobulin class switch recombination and switch translocations in activated B cell-like diffuse large B cell lymphoma by Lenz, Georg, Nagel, Inga, Siebert, Reiner, Roschke, Anna V, Sanger, Warren, Wright, George W, Dave, Sandeep S, Tan, Bruce, Zhao, Hong, Rosenwald, Andreas, Muller-Hermelink, Hans Konrad, Gascoyne, Randy D, Campo, Elias, Jaffe, Elaine S, Smeland, Erlend B, Fisher, Richard I, Kuehl, W Michael, Chan, Wing C, Staudt, Louis M

“…To elucidate the mechanisms underlying chromosomal translocations in diffuse large B cell lymphoma (DLBCL), we investigated the nature and extent of…”
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Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma by Affer, M, Chesi, M, Chen, W D, Keats, J J, Demchenko, Y N, Tamizhmani, K, Garbitt, V M, Riggs, D L, Brents, L A, Roschke, A V, Van Wier, S, Fonseca, R, Bergsagel, P L, Kuehl, W M

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Cutting Edge: A Role for B Lymphocyte Stimulator in Systemic Lupus Erythematosus by Zhang, Jun, Roschke, Viktor, Baker, Kevin P, Wang, Zheng, Alarcon, Graciela S, Fessler, Barri J, Bastian, Holly, Kimberly, Robert P, Zhou, Tong

“…Increased levels of B lymphocyte stimulator (BLyS) are associated with systemic autoimmunity in animal models of spontaneous autoimmune disease, and transgenic…”
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Novel near-diploid ovarian cancer cell line derived from a highly aneuploid metastatic ovarian tumor by Rozenblum, Ester, Sotelo-Silveira, Jose R, Kim, Gina Y, Zhu, Jack Y, Lau, Christopher C, McNeil, Nicole, Korolevich, Susana, Liao, Hongling, Cherry, James M, Munroe, David J, Ried, Thomas, Meltzer, Paul S, Kuehl, Walter M, Roschke, Anna V

“…A new ovarian near-diploid cell line, OVDM1, was derived from a highly aneuploid serous ovarian metastatic adenocarcinoma. A metastatic tumor was obtained from…”
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Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis by Kanakaraj, Palanisamy, Puffer, Bridget A., Yao, Xiao-Tao, Kankanala, Spandana, Boyd, Ernest, Shah, Rutul R., Wang, Geping, Patel, Dimki, Krishnamurthy, Rajesh, Kaithamana, Shashi, Smith, Rodger G., LaFleur, David W., Barbas III, Carlos F., Hilbert, David M., Kiener, Peter A., Roschke, Viktor V.

“…Despite the clinical success of anti-tumor necrosis factor (TNF) therapies in the treatment of inflammatory conditions such as rheumatoid arthritis, Crohn…”
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Karyotypic complexity of the NCI-60 drug-screening panel by ROSCHKE, Anna V, TONON, Giovanni, GEHLHAUS, Kristen S, MCTYRE, Nicolas, BUSSEY, Kimberly J, LABABIDI, Samir, SCUDIERO, Dominic A, WEINSTEIN, John N, KIRSCH, Ilan R

“…We used spectral karyotyping to provide a detailed analysis of karyotypic aberrations in the diverse group of cancer cell lines established by the National…”
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Inverse association between circulating APRIL levels and serological and clinical disease activity in patients with systemic lupus erythematosus by Stohl, W, Metyas, S, Tan, S-M, Cheema, G S, Oamar, B, Roschke, V, Wu, Y, Baker, K P, Hilbert, D M

“…Objective: To assess longitudinal expression of a proliferation-inducing ligand (APRIL) in patients with systemic lupus erythematosus (SLE) and its correlation…”
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Chromosomal Instability Is Associated with Higher Expression of Genes Implicated in Epithelial-Mesenchymal Transition, Cancer Invasiveness, and Metastasis and with Lower Expression of Genes Involved in Cell Cycle Checkpoints, DNA Repair, and Chromatin Maintenance by Roschke, Anna V., Glebov, Oleg K., Lababidi, Samir, Gehlhaus, Kristen S., Weinstein, John N., Kirsch, Ilan R.

“…Chromosomal instability—a hallmark of epithelial cancers—is an ongoing process that results in aneuploidy and karyotypic heterogeneity of a cancer cell…”
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Stable Karyotypes in Epithelial Cancer Cell Lines Despite High Rates of Ongoing Structural and Numerical Chromosomal Instability by Roschke, Anna V., Stover, Kristen, Tonon, Giovanni, Schäffer, Alejandro A., Kirsch, Ilan R.

“…Most human tumors and tumor cell lines exhibit numerical and structural chromosomal abnormalities. The goal of this study was to determine the ongoing rates of…”
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A Revision of the Lissencephaly and Miller-Dieker Syndrome Critical Regions in Chromosome 17p13.3 by Chong, Samuel S., Pack, Svetlana D., Roschke, Anna V., Tanigami, Akira, Carrozzo, Romeo, Smith, Ann C. M., Dobyns, William B., Ledbetter, David H.

“…Miller-Dieker syndrome (MDS) is a multiple malformation syndrome characterized by classical lissencephaly and a characteristic facies. It is associated with…”
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PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer by XU, Linda L, STACKHOUSE, Bennett G, CARTER, Kenneth, MCLEOD, David G, MOUL, Judd W, SOPPETT, Dan, SRIVASTAVA, Shiv, FLORENCE, Kim, WEI ZHANG, SHANMUGAM, Naga, SESTERHENN, Iasbell A, ZHIQIANG ZOU, SRIKANTAN, Vasantha, AUGUSTUS, Meena, ROSCHKE, Viktor

“…PSGR, a new prostate tissue-specific gene with homology to the G protein-coupled odorant receptor gene family, has been identified. Here we report the…”
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Targeting Cancer Cells by Exploiting Karyotypic Complexity and Chromosomal Instability by Roschke, Anna V., Kirsch, Ilan R.

“…Multiple karyotypic abnormalities and chromosomal instability are particular hallmarks of many cancers that are relatively resistant to long term control by…”
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Karyotypic "State" as a Potential Determinant for Anticancer Drug Discovery by Roschke, Anna V., Lababidi, Samir, Tonon, Giovanni, Gehlhaus, Kristen S., Bussey, Kimberly, Weinstein, John N., Kirsch, Ilan R., de la Chapelle, Albert

“…Cancer is a genetic disease caused by genomic instability. In many cancers, this instability is manifested by chromosomal reconfigurations and karyotypic…”
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Rapid and reversible suppression of ALT by DAXX in osteosarcoma cells by Yost, Kathryn E., Clatterbuck Soper, Sarah F., Walker, Robert L., Pineda, Marbin A., Zhu, Yuelin J., Ester, Corbin D., Showman, Soyeon, Roschke, Anna V., Waterfall, Joshua J., Meltzer, Paul S.

“…Many tumors maintain chromosome-ends through a telomerase-independent, DNA-templated mechanism called alternative lengthening of telomeres (ALT). While ALT…”
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High serum levels of B‐lymphocyte stimulator are associated with clinical–pathological features and outcome in classical Hodgkin lymphoma by Tecchio, C., Nadali, G., Scapini, P., Bonetto, C., Visco, C., Tamassia, N., Vassilakopoulos, T. P., Pangalis, G. A., Calzetti, F., Nardelli, B., Roschke, V., Gottardi, M., Zampieri, F., Gherlinzoni, F., Facchetti, F., Pizzolo, G., Cassatella, M. A.

“…Summary B‐lymphocyte stimulator (BLyS) acts as survival factor for B lymphocytes. As Hodgkin and Reed‐Sternberg (HRS) cells express receptors through which…”
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