Search Results - "Roscher, Adelbert"

Late-pregnancy dysglycemia in obese pregnancies after negative testing for gestational diabetes and risk of future childhood overweight: An interim analysis from a longitudinal mother-child cohort study by Gomes, Delphina, von Kries, Rüdiger, Delius, Maria, Mansmann, Ulrich, Nast, Martha, Stubert, Martina, Langhammer, Lena, Haas, Nikolaus A, Netz, Heinrich, Obermeier, Viola, Kuhle, Stefan, Holdt, Lesca M, Teupser, Daniel, Hasbargen, Uwe, Roscher, Adelbert A, Ensenauer, Regina

“…Maternal pre-conception obesity is a strong risk factor for childhood overweight. However, prenatal mechanisms and their effects in susceptible gestational…”
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Digital image analysis approach for lipid droplet size quantitation of Oil Red O-stained cultured cells by Deutsch, Manuel J., Schriever, Sonja C., Roscher, Adelbert A., Ensenauer, Regina

“…A simple approach was developed for the quantification of lipid droplet size and frequency distribution in images acquired by standard light microscopy. Oil…”
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Predicting the earliest deviation in weight gain in the course towards manifest overweight in offspring exposed to obesity in pregnancy: a longitudinal cohort study by Gomes, Delphina, Le, Lien, Perschbacher, Sarah, Haas, Nikolaus A, Netz, Heinrich, Hasbargen, Uwe, Delius, Maria, Lange, Kristin, Nennstiel, Uta, Roscher, Adelbert A, Mansmann, Ulrich, Ensenauer, Regina

“…Obesity in pregnancy and related early-life factors place the offspring at the highest risk of being overweight. Despite convincing evidence on these…”
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Cleavage of CXCR1 on neutrophils disables bacterial killing in cystic fibrosis lung disease by Hartl, Dominik, Latzin, Philipp, Hordijk, Peter, Marcos, Veronica, Rudolph, Carsten, Woischnik, Markus, Krauss-Etschmann, Susanne, Koller, Barbara, Reinhardt, Dietrich, Roscher, Adelbert A, Roos, Dirk, Griese, Matthias

“…Interleukin-8 (IL-8) activates neutrophils via the chemokine receptors CXCR1 and CXCR2. However, the airways of individuals with cystic fibrosis are frequently…”
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RNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes by Fleischmann, Katrin K, Pagel, Philipp, Schmid, Irene, Roscher, Adelbert A

“…The translocation t(9;11)(p22;q23) leading to the leukemogenic fusion gene MLL-AF9 is a frequent translocation in infant acute myeloid leukemia (AML). This…”
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Sex-specific programming effects of parental obesity in pre-implantation embryonic development by Hedegger, Kathrin, Philippou-Massier, Julia, Krebs, Stefan, Blum, Helmut, Kunzelmann, Stefan, Förstemann, Klaus, Gimpfl, Martina, Roscher, Adelbert A., Ensenauer, Regina, Wolf, Eckhard, Dahlhoff, Maik

“…Background Obesity is a global rising problem with epidemiological dimension. Obese parents can have programming effects on their offspring leading to obesity…”
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Loss of Function in Phenylketonuria Is Caused by Impaired Molecular Motions and Conformational Instability by Gersting, Søren W., Kemter, Kristina F., Staudigl, Michael, Messing, Dunja D., Danecka, Marta K., Lagler, Florian B., Sommerhoff, Christian P., Roscher, Adelbert A., Muntau, Ania C.

“…A significant share of patients with phenylalanine hydroxylase (PAH) deficiency benefits from pharmacological doses of tetrahydrobiopterin (BH 4), the natural…”
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Stability of Acylcarnitines and Free Carnitine in Dried Blood Samples: Implications for Retrospective Diagnosis of Inborn Errors of Metabolism and Neonatal Screening for Carnitine Transporter Deficiency by Fingerhut, Ralph, Ensenauer, Regina, Röschinger, Wulf, Arnecke, Ralf, Olgemöller, Bernhard, Roscher, Adelbert A

“…Objective: Electrospray ionization-tandem mass spectrometry (ESI-MS/MS) is increasingly used in newborn screening programs. Acylcarnitine profiles from dried…”
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Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism by Schriever, Sonja C., Deutsch, Manuel J., Adamski, Jerzy, Roscher, Adelbert A., Ensenauer, Regina

“…The regulation of cell growth and protein biosynthesis is triggered by the mammalian target of rapamycin complex 1 (mTORC1) responding to amino acids,…”
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Obese Nondiabetic Pregnancies and High Maternal Glycated Hemoglobin at Delivery as an Indicator of Offspring and Maternal Postpartum Risks: The Prospective PEACHES Mother-Child Cohort by Ensenauer, Regina, Brandlhuber, Lena, Burgmann, Maximiliane, Sobotzki, Christina, Zwafink, Carina, Anzill, Sabine, Holdt, Lesca, Teupser, Daniel, Hasbargen, Uwe, Netz, Heinrich, Roscher, Adelbert A, von Kries, Rüdiger

“…We investigated whether obese pregnant women negative for gestational diabetes (GDM) still experience dysglycemia, as indicated by high glycated hemoglobin (Hb…”
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Changing Metabolic Signatures of Amino Acids and Lipids During the Prediabetic Period in a Pig Model With Impaired Incretin Function and Reduced β-Cell Mass by RENNER, Simone, RÖMISCH-MARGL, Werner, PREHN, Cornelia, KREBS, Stefan, ADAMSKI, Jerzy, GÖKE, Burkhard, BLUM, Helmut, SUHRE, Karsten, ROSCHER, Adelbert A, WOLF, Eckhard

“…Diabetes is generally diagnosed too late. Therefore, biomarkers indicating early stages of β-cell dysfunction and mass reduction would facilitate timely…”
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Tetrahydrobiopterin as an Alternative Treatment for Mild Phenylketonuria by Muntau, Ania C, Röschinger, Wulf, Habich, Matthias, Demmelmair, Hans, Hoffmann, Björn, Sommerhoff, Christian P, Roscher, Adelbert A

“…Patients with hyperphenylalaninemia due to phenylalanine hydroxylase deficiency require low-phenylalanine diets, even those with mild disease. This study…”
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Disease manifestations and X inactivation in heterozygous females with Fabry disease by Maier, Esther M, Osterrieder, Stephanie, Whybra, Catharina, Ries, Markus, Gal, Andreas, Beck, Michael, Roscher, Adelbert A, Muntau, Ania C

“…Fabry disease is an X-linked lysosomal storage disorder characterized by an accumulation of neutral glycosphingolipids in multiple organ systems caused by…”
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Modification of the fatty acid composition of an obesogenic diet improves the maternal and placental metabolic environment in obese pregnant mice by Gimpfl, Martina, Rozman, Jan, Dahlhoff, Maik, Kübeck, Raphaela, Blutke, Andreas, Rathkolb, Birgit, Klingenspor, Martin, Hrabě de Angelis, Martin, Öner-Sieben, Soner, Seibt, Annette, Roscher, Adelbert A., Wolf, Eckhard, Ensenauer, Regina

“…Peri-conceptional exposure to maternal obesogenic nutrition is associated with in utero programming of later-life overweight and metabolic disease in the…”
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Screening for Congenital Adrenal Hyperplasia: Adjustment of 17-Hydroxyprogesterone Cut-Off Values to Both Age and Birth Weight Markedly Improves the Predictive Value by Olgemöller, Bernhard, Roscher, Adelbert A., Liebl, Bernhard, Fingerhut, Ralph

“…Newborn screening procedures for congenital adrenal hyperplasia (CAH) are still suboptimal because of low specificity, particularly in premature infants. This…”
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The leukemogenic fusion gene MLL-AF9 alters microRNA expression pattern and inhibits monoblastic differentiation via miR-511 repression by Fleischmann, Katrin K, Pagel, Philipp, von Frowein, Julia, Magg, Thomas, Roscher, Adelbert A, Schmid, Irene

“…In this study we explored the role of microRNAs (miRNAs) as mediators of leukemogenic effects of the fusion gene MLL-AF9, which results from a frequent…”
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In situ assay of fatty acid β-oxidation by metabolite profiling following permeabilization of cell membranes by Ensenauer, Regina, Fingerhut, Ralph, Schriever, Sonja C., Fink, Barbara, Becker, Marc, Sellerer, Nina C., Pagel, Philipp, Kirschner, Andreas, Dame, Torsten, Olgemöller, Bernhard, Röschinger, Wulf, Roscher, Adelbert A.

“…Quantitative analysis of mitochondrial FA β-oxidation (FAO) has drawn increasing interest for defining lipid-induced metabolic dysfunctions, such as in…”
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Population spectrum of ACADM genotypes correlated to biochemical phenotypes in newborn screening for medium-chain acyl-CoA dehydrogenase deficiency by Maier, Esther M., Liebl, Bernhard, Röschinger, Wulf, Nennstiel-Ratzel, Uta, Fingerhut, Ralph, Olgemöller, Bernhard, Busch, Ulrich, Krone, Nils, Kries, Rüdiger v., Roscher, Adelbert A.

“…Medium‐chain acyl‐CoA dehydrogenase deficiency (MCADD) is the most frequent inherited defect of fatty acid oxidation, with a significant morbidity and…”
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Newborn screening for 3-methylcrotonyl-CoA carboxylase deficiency: population heterogeneity of MCCA and MCCB mutations and impact on risk assessment by Stadler, Sonja C., Polanetz, Roman, Maier, Esther M., Heidenreich, Sylvia C., Niederer, Birgit, Mayerhofer, Peter U., Lagler, Florian, Koch, Hans-Georg, Santer, René, Fletcher, Janice M., Ranieri, Enzo, Das, Anibh M., Spiekerkötter, Ute, Schwab, Karl O., Pötzsch, Simone, Marquardt, Iris, Hennermann, Julia B., Knerr, Ina, Mercimek-Mahmutoglu, Saadet, Kohlschmidt, Nicolai, Liebl, Bernhard, Fingerhut, Ralph, Olgemöller, Bernhard, Muntau, Ania C., Roscher, Adelbert A., Röschinger, Wulf

“…New technology enables expansion of newborn screening (NBS) of inborn errors aimed to prevent adverse outcome. In conditions with a large share of asymptomatic…”
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Predicting Phenotype in Steroid 21-Hydroxylase Deficiency? Comprehensive Genotyping in 155 Unrelated, Well Defined Patients from Southern Germany by Krone, Nils, Braun, Andreas, Roscher, Adelbert Anton, Knorr, Dietrich, Schwarz, Hans Peter

“…Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders. CAH is most often caused by deficiency of steroid 21-hydroxylase. The…”
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