Search Results - "Rosato, Umberto"

Targeting the crosstalk between cytokine-induced killer cells and myeloid-derived suppressor cells in hepatocellular carcinoma by Yu, Su Jong, Ma, Chi, Heinrich, Bernd, Brown, Zachary J., Sandhu, Milan, Zhang, Qianfei, Fu, Qiong, Agdashian, David, Rosato, Umberto, Korangy, Firouzeh, Greten, Tim F.

“…[Display omitted] •CIK therapy recruits MDSCs in tumor tissues through inflammatory cytokines.•MDSCs inhibit CIK tumor lytic function in an ARG1 and iNOS…”
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Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma by Zhang, Qianfei, Ma, Chi, Duan, Yi, Heinrich, Bernd, Rosato, Umberto, Diggs, Laurence P, Ma, Lichun, Roy, Soumen, Fu, Qiong, Brown, Zachary J, Wabitsch, Simon, Thovarai, Vishal, Fu, Jianyang, Feng, Dechun, Ruf, Benjamin, Cui, Linda L, Subramanyam, Varun, Frank, Karen M, Wang, Sophie, Kleiner, David E, Ritz, Thomas, Rupp, Christian, Gao, Bin, Longerich, Thomas, Kroemer, Alexander, Wang, Xin Wei, Ruchirawat, Mathuros, Korangy, Firouzeh, Schnabl, Bernd, Trinchieri, Giorgio, Greten, Tim F

“…Gut dysbiosis is commonly observed in patients with cirrhosis and chronic gastrointestinal disorders; however, its effect on antitumor immunity in the liver is…”
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Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD by Ma, Chi, Fu, Qiong, Diggs, Laurence P., McVey, John C., McCallen, Justin, Wabitsch, Simon, Ruf, Benjamin, Brown, Zachary, Heinrich, Bernd, Zhang, Qianfei, Rosato, Umberto, Wang, Sophie, Cui, Linda, Berzofsky, Jay A., Kleiner, David E., Bosco, Dale B., Wu, Long-Jun, Lai, Chunwei Walter, Rotman, Yaron, Xie, Changqing, Korangy, Firouzeh, Greten, Tim F.

“…Platelets, the often-overlooked component of the immune system, have been shown to promote tumor growth. Nonalcoholic fatty liver disease (NAFLD) is a common…”
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CD40-mediated immune cell activation enhances response to anti-PD-1 in murine intrahepatic cholangiocarcinoma by Diggs, Laurence P., Ruf, Benjamin, Ma, Chi, Heinrich, Bernd, Cui, Linda, Zhang, Qianfei, McVey, John C., Wabitsch, Simon, Heinrich, Sophia, Rosato, Umberto, Lai, Walter, Subramanyam, Varun, Longerich, Thomas, Loosen, Sven H., Luedde, Tom, Neumann, Ulf Peter, Desar, Sabina, Kleiner, David, Gores, Gregory, Wang, Xin Wei, Greten, Tim F.

“…While cholangiocarcinomas (CCAs) commonly express programmed cell death 1 (PD-1) and its ligand (PD-L1), they respond poorly to immune checkpoint inhibitors…”
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Steatohepatitis Impairs T-cell–Directed Immunotherapies Against Liver Tumors in Mice by Heinrich, Bernd, Brown, Zachary J., Diggs, Laurence P., Vormehr, Mathias, Ma, Chi, Subramanyam, Varun, Rosato, Umberto, Ruf, Benjamin, Walz, Juliane S., McVey, John C., Wabitsch, Simon, Fu, Qiong, Yu, Su Jong, Zhang, Qianfei, Lai, Chunwei W., Sahin, Ugur, Greten, Tim F.

“…Nonalcoholic steatohepatitis causes loss of hepatic CD4+ T cells and promotes tumor growth. The liver is the most common site of distant metastases from a…”
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The tumour microenvironment shapes innate lymphoid cells in patients with hepatocellular carcinoma by Heinrich, Bernd, Gertz, E Michael, Schäffer, Alejandro A, Craig, Amanda, Ruf, Benjamin, Subramanyam, Varun, McVey, John C, Diggs, Laurence P, Heinrich, Sophia, Rosato, Umberto, Ma, Chi, Yan, Chunhua, Hu, Ying, Zhao, Yongmei, Shen, Tsai-Wei, Kapoor, Veena, Telford, William, Kleiner, David E, Stovroff, Merril K, Dhani, Harmeet S, Kang, Jiman, Fishbein, Thomas, Wang, Xin Wei, Ruppin, E, Kroemer, Alexander, Greten, Tim F, Korangy, Firouzeh

“…Hepatocellular carcinoma (HCC) represents a typical inflammation-associated cancer. Tissue resident innate lymphoid cells (ILCs) have been suggested to control…”
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The Methyltransferase Set7/9 (Setd7) Is Dispensable for the p53-Mediated DNA Damage Response In Vivo by Campaner, Stefano, Spreafico, Fabio, Burgold, Thomas, Doni, Mirko, Rosato, Umberto, Amati, Bruno, Testa, Giuseppe

“…p53 is the central regulator of cell fate following genotoxic stress and oncogene activation. Its activity is controlled by several posttranslational…”
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Abstract 1526: Colitis promotes intrahepatic cholangiocarcinoma via gut microbiome dependent, CXCL1/CXCR2 mediated MDSC accumulation by Zhang, Qianfei, Ma, Chi, Rosato, Umberto, Heinrich, Bernd, Fu, Qiong, Laurence, Diggs, Greten, Tim

“…Abstract Inflammatory bowel disease (IBD) is a known risk factor for cholangiocarcinoma. Gut microbiome dysregulation is closely associate with IBD, however,…”
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Abstract 2582: Regulatory T cells restrain efficacy of immunotherapy in murine liver tumors by Green, Benjamin L., Ma, Chi, Zhang, Qianfei, Ruf, Benjamin, Rosato, Umberto, Qi, Jonathan, Wabitsch, Simon, Bauer, Kylynda, Myojin, Yuta, McCallen, Justin, McVey, John C., Subramanyam, Varun, Catania, Vanessa, Nur, Amran, Korangy, Firouzeh, Xie, Changqing, Greten, Tim F.

“…Abstract Background: Checkpoint blockade immunotherapy (CBI) can induce a durable response for some patients with hepatic tumors, but many derive no or…”
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