Search Results - "Rosano, Thomas G"

Quantitation of propofol metabolites by LC–MS/MS demonstrating long detection window for urine drug monitoring by Rosano, Thomas G., Wood, Michelle, Scholz, Kiley L., Whitely, Kiera, Kim, Nathaniel, Ehlers, Melissa

“…•The chromatographic method is useful in propofol analysis.•It uses a dilute-and-analyze sample preparation.•The method has a linear calibration model.•It can…”
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Refining Vancomycin Protein Binding Estimates: Identification of Clinical Factors That Influence Protein Binding by Butterfield, Jill M, Patel, Nimish, Pai, Manjunath P, Rosano, Thomas G, Drusano, George L, Lodise, Thomas P

“…While current data indicate only free (unbound) drug is pharmacologically active and is most predictive of response, pharmacodynamic studies of vancomycin have…”
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Confirmation of cannabinoids in forensic toxicology casework by isomer-selective UPLC–MS-MS analysis in urine by Rosano, Thomas G, Cooper, Jane A, Scholz, Kiley L, Wood, Michelle

“…Abstract Confirmation of cannabinoid use by forensic toxicology testing in urine has been traditionally focused on ∆9-tetrahydrocannabinol (∆9-THC) with…”
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Matrix Normalization Techniques for Definitive Urine Drug Testing by Rosano, Thomas G, Rumberger, John M, Wood, Michelle

“…Abstract Analytical performance of stable isotope-labeled internal standardization (SIL-IS) and threshold accurate calibration (TAC) methods of matrix…”
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Application and Clinical Value of Definitive Drug Monitoring in Pain Management and Addiction Medicine by Rosano, Thomas G, Wood, Michelle, Hooten, W Michael, Rumberger, John M, Fudin, Jeffrey, Argoff, Charles E

“…Abstract Objective To assess routine application and clinical value of definitive urine drug monitoring (UDM) for drug detection, inconsistent drug use, and…”
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Application of High-Resolution UPLC–MSE/TOF Confirmation in Forensic Urine Drug Screening by UPLC–MS/MS by Rosano, Thomas G, Ohouo, Patrice Y, Wood, Michelle

“…Abstract The transition from presumptive (immunoassay) drug screening to definitive screening has continued in the practice of analytical toxicology…”
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Screening with Quantification for 64 Drugs and Metabolites in Human Urine using UPLC–MS-MS Analysis and a Threshold Accurate Calibration by Rosano, Thomas G., Ohouo, Patrice Y., Wood, Michelle

“…Abstract Drug and metabolite (analytes) identification together with quantification is an important analytical tool in forensic and clinical toxicology. We…”
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Multi-drug and Metabolite Quantification in Postmortem Blood by Liquid Chromatography–High-Resolution Mass Spectrometry: Comparison with Nominal Mass Technology by Rosano, Thomas G., Na, Seo, Ihenetu, Kenneth, Swift, Thomas A., Wood, Michelle

“…High-resolution mass spectrometry (HRMS) is being applied in postmortem drug screening as an alternative to nominal mass spectrometry, and additional…”
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Utility of Commercial Ethyl Glucuronide (EtG) and Ethyl Sulfate (EtS) Testing for Detection of Lighter Drinking Among Women of Childbearing Years by Graham, Amy E, Beatty, Jessica R, Rosano, Thomas G, Sokol, Robert J, Ondersma, Steven J

“…Even moderate alcohol consumption during pregnancy can pose risks to the fetus, making reliable and consistent detection of drinking in pregnancy critical…”
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Drug screening in medical examiner casework by high-resolution mass spectrometry (UPLC-MSE-TOF) by Rosano, Thomas G, Wood, Michelle, Ihenetu, Kenneth, Swift, Thomas A

“…Postmortem drug findings yield important analytical evidence in medical examiner casework, and chromatography coupled with nominal mass spectrometry (MS)…”
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Novel Matrix Normalization Technique for Accurate LC-ESI-MS/MS Detection and Quantification of Drugs and Their Metabolites in Toxicology Research and Practice by Rosano, Thomas G, Rumberger, John M, Scholz, Kiley L, Konetchy, Jr, Robert M, Wood, Michelle

“…Accurate identification and quantification of drugs and their metabolites (analytes) in biological matrices is an analytical foundation of clinical and…”
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Measurement of unconjugated estriol in serum by liquid chromatography-tandem mass spectrometry and assessment of the accuracy of chemiluminescent immunoassays by Huang, Xianzhang, Spink, David C, Schneider, Erasmus, Ling, Helen, Rai, Alex J, Rosano, Thomas G, Chen, Baorong, Cao, Zhimin Tim

“…Unconjugated estriol (uE3) is routinely analyzed in clinical laboratories as risk assessment for Down syndrome. Immunoassays of various types are the most…”
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Acrolein in cigarette smoke inhibits T-cell responses by Lambert, Cherie, McCue, Jesica, Portas, Mary, Ouyang, Yanli, Li, JiMei, Rosano, Thomas G., Lazis, Alexander, Freed, Brian M.

“…Cigarette smoking inhibits T-cell responses in the lungs, but the immunosuppressive compounds have not been fully identified. Cigarette smoke extracts inhibit…”
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Definitive Drug and Metabolite Screening in Urine by UPLC–MS-MS Using a Novel Calibration Technique by Rosano, Thomas G., Ohouo, Patrice Y., LeQue, John J., Freeto, Scott M., Wood, Michelle

“…Drug screening is an essential analytical tool for detection of therapeutic, illicit and emerging drug use. Presumptive immunoassay screening is widely used,…”
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Postmortem Drug Screening by Non-Targeted and Targeted Ultra-Performance Liquid Chromatography-Mass Spectrometry Technology by Rosano, Thomas G., Wood, Michelle, Swift, Thomas A.

“…In the medical examiner setting, comprehensive drug screening is an essential analytical tool in the investigation of cause and manner of death. We have…”
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Commercial Ethyl Glucuronide (EtG) and Ethyl Sulfate (EtS) Testing is Not Vulnerable to Incidental Alcohol Exposure in Pregnant Women by Ondersma, Steven J, Beatty, Jessica R, Rosano, Thomas G, Strickler, Ronald C, Graham, Amy E, Sokol, Robert J

“…Ethyl Glucoronide (EtG) and Ethyl Sulfate (EtS) have shown promise as biomarkers for alcohol and may be sensitive enough for use with pregnant women in whom…”
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Ethyl Glucuronide Excretion in Humans Following Oral Administration of and Dermal Exposure to Ethanol by Rosano, Thomas G., Lin, Jing

“…Ethyl glucuronide (EtG) is a direct ethanol biomarker and U.S. Department of Health and Human Services has advised that specificity studies at low EtG levels…”
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Ethylene Glycol and Glycolic Acid in Postmortem Blood from Fatal Poisonings by Rosano, Thomas G., Swift, Thomas A., Kranick, Christopher J., Sikirica, Michael

“…Ethylene glycol (EG), a relatively infrequent cause of fatal intoxication, presents an analytical challenge for forensic confirmation in postmortem toxicology…”
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Insulin Glargine and Insulin Aspart Overdose With Pharmacokinetic Analysis by Kim, Christian C.K., Rosano, Thomas G., Chambers, Erin E., Pai, Manjunath P., Desemone, James

“…Objective: Insulin glargine is a long-acting insulin analogue with biotransformation, at the injection site, to a primary active metabolite (glargine-M1)…”
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Analysis of 17 fentanyls in plasma and blood by UPLC-MS/MS with interpretation of findings in surgical and postmortem casework by Danaceau, Jonathan P., Wood, Michelle, Ehlers, Melissa, Rosano, Thomas G.

“…•Identification and quantitation of fentanyls is needed in the clinical practice setting.•A UPLC-MS/MS method has been validated in plasma and whole…”
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