Search Results - "Rosanna, Supino"

miR-21: an oncomir on strike in prostate cancer by Folini, Marco, Gandellini, Paolo, Longoni, Nicole, Profumo, Valentina, Callari, Maurizio, Pennati, Marzia, Colecchia, Maurizio, Supino, Rosanna, Veneroni, Silvia, Salvioni, Roberto, Valdagni, Riccardo, Daidone, Maria Grazia, Zaffaroni, Nadia

“…Aberrant expression of microRNAs, small non-coding RNA molecules that post-transcriptionally repress gene expression, seems to be causatively linked to the…”
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Kinetics of novel competitive inhibitors of urease enzymes by a focused library of oxadiazoles/thiadiazoles and triazoles by Amtul, Zareen, Rasheed, Maimoona, Choudhary, Mohammad Iqbal, Rosanna, Supino, Khan, Khalid M., Atta-ur-Rahman

“…Based on structure of the substrate of urease and for the purpose of designing pharmacophore models for urease inhibitors, which could be effective in…”
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Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification by le Coutre, Philipp, Tassi, Elena, Varella-Garcia, Marileila, Barni, Rossella, Mologni, Luca, Cabrita, Gonçalo, Marchesi, Edoardo, Supino, Rosanna, Gambacorti-Passerini, Carlo

“…The 2-phenylaminopyrimidine derivative STI571 has been shown to selectively inhibit the tyrosine kinase domain of the oncogenicbcr/abl fusion protein. The…”
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BBR 3464: A Novel Triplatinum Complex, Exhibiting a Preclinical Profile of Antitumor Efficacy Different from Cisplatin by MANZOTTI, C, PRATESI, G, PEZZONI, G, ZUNINO, F, MENTA, E, DI DOMENICO, R, CAVALLETTI, E, FIEBIG, H. H, KELLAND, L. R, FARRELL, N, POLIZZI, D, SUPINO, R

“…Multinuclear platinum complexes represent a new class of anticancer agents, distinct in terms of DNA binding features and the profile of antitumor activity…”
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Antimetastatic effect of a small-molecule vacuolar H+-ATPase inhibitor in in vitro and in vivo preclinical studies by Supino, Rosanna, Petrangolini, Giovanna, Pratesi, Graziella, Tortoreto, Monica, Favini, Enrica, Bo, Laura Dal, Casalini, Patrizia, Radaelli, Enrico, Croce, Anna Cleta, Bottiroli, Giovanni, Misiano, Paola, Farina, Carlo, Zunino, Franco

“…On the basis of the evidence that vacuolar H(+)-ATPase is implicated in the development of the metastatic phenotype, we have explored the possibility to target…”
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Effect of a novel vacuolar-H+-ATPase inhibitor on cell and tumor response to camptothecins by Petrangolini, Giovanna, Supino, Rosanna, Pratesi, Graziella, Dal Bo, Laura, Tortoreto, Monica, Croce, Anna Cleta, Misiano, Paola, Belfiore, Pietro, Farina, Carlo, Zunino, Franco

“…The vacuolar-H(+)-ATPase, functionally expressed in cell membranes, is known to play a relevant role in intracellular pH regulatory mechanisms, because it is…”
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Inhibition of c-Met and prevention of spontaneous metastatic spreading by the 2-indolinone RPI-1 by Cassinelli, Giuliana, Lanzi, Cinzia, Petrangolini, Giovanna, Tortoreto, Monica, Pratesi, Graziella, Cuccuru, Giuditta, Laccabue, Diletta, Supino, Rosanna, Belluco, Sara, Favini, Enrica, Poletti, Anna, Zunino, Franco

“…Hepatocyte growth factor (HGF) and its tyrosine kinase receptor Met play a pivotal role in the tumor metastatic phenotype and represent attractive therapeutic…”
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A novel trinuclear platinum complex overcomes cisplatin resistance in an osteosarcoma cell system by Perego, P, Caserini, C, Gatti, L, Carenini, N, Romanelli, S, Supino, R, Colangelo, D, Viano, I, Leone, R, Spinelli, S, Pezzoni, G, Manzotti, C, Farrell, N, Zunino, F

“…Multinuclear platinum compounds have been designed to circumvent the cellular resistance to conventional platinum-based drugs. In an attempt to examine the…”
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Role of apoptosis and apoptosis-related genes in cellular response and antitumor efficacy of anthracyclines by Perego, P, Corna, E, De Cesare, M, Gatti, L, Polizzi, D, Pratesi, G, Supino, R, Zunino, F

“…Cellular resistance to anthracyclines is a major limitation of their clinical use in the treatment of human tumors. Resistance to doxorubicin is described as a…”
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Nitroxide TEMPOL impairs mitochondrial function and induces apoptosis in HL60 cells by Monti, Elena, Supino, Rosanna, Colleoni, Mariapia, Costa, Barbara, Ravizza, Raffaella, Gariboldi, Marzia B.

“…The piperidine nitroxide TEMPOL induces apoptosis in a number of tumor cell lines through free radical‐dependent mechanisms. As mitochondria play a major role…”
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Cell cycle checkpoint efficiency and cellular response to paclitaxel in prostate cancer cells by Lanzi, Cinzia, Cassinelli, Giuliana, Cuccuru, Giuditta, Supino, Rosanna, Zuco, Valentina, Ferlini, Cristiano, Scambia, Giovanni, Zunino, Franco

“…BACKGROUND Defects in the cell cycle machinery of prostate cancer cells might impair the efficiency of cell cycle checkpoints and affect the cell response to…”
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Development of Resistance to the Atypical Retinoid, ST1926, in the Lung Carcinoma Cell Line H460 Is Associated with Reduced Formation of DNA Strand Breaks and a Defective DNA Damage Response by Zuco, Valentina, Zanchi, Chiara, Lanzi, Cinzia, Beretta, Giovanni L., Supino, Rosanna, Pisano, Claudio, Barbarino, Marcella, Zanier, Romina, Bucci, Federica, Aulicino, Concetta, Carminati, Paolo, Zunino, Franco

“…Atypical retinoids are potent inducers of apoptosis, but activation of the apoptotic pathway seems to be independent of retinoid receptors. Previous studies…”
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Cellular Bases of the Antitumor Activity of the Novel Taxane IDN 5109 (BAY59-8862) on Hormone-refractory Prostate Cancer by Cassinelli, Giuliana, Lanzi, Cinzia, Supino, Rosanna, Pratesi, Graziella, Zuco, Valentina, Laccabue, Diletta, Cuccuru, Giuditta, Bombardelli, Ezio, Zunino, Franco

“…Taxane-based therapies appear to have a significant efficacyin clinical trials on hormone-refractory prostate carcinoma. In the present study, we investigated…”
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Cellular Basis of Antiproliferative and Antitumor Activity of the Novel Camptothecin Derivative, Gimatecan, in Bladder Carcinoma Models by Ulivi, Paola, Zoli, Wainer, Fabbri, Francesco, Brigliadori, Giovanni, Ricotti, Luca, Tesei, Anna, Rosetti, Marco, De Cesare, Michelandrea, Beretta, Giovanni L., Corna, Elisabetta, Supino, Rosanna, Zunino, Franco

“…To investigate the cellular/molecular basis of the activity of a novel lipophilic camptothecin, gimatecan (ST1481), against slowly proliferating cells, we…”
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miR-205 Exerts Tumor-Suppressive Functions in Human Prostate through Down-regulation of Protein Kinase Cε by GANDELLINI, Paolo, FOLINI, Marco, VALDAGN, Riccardo, GRAZIA DAIDONE, Maria, ZAFFARONI, Nadia, LONGONI, Nicole, PENNATI, Marzia, BIND, Mara, COLECCHIA, Maurizio, SALVIONI, Roberto, SUPINO, Rosanna, MORETTI, Roberta, LIMONTA, Patrizia

“…Abstract Limited information is available concerning the expression and role of microRNAs in prostate cancer. In this study, we investigated the involvement of…”
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The nitroxide tempol induces oxidative stress, p21WAF1/CIP1, and cell death in HL60 cells by Gariboldi, Marzia B, Rimoldi, Valeria, Supino, Rosanna, Favini, Enrica, Monti, Elena

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MRP gene overexpression in a human doxorubicin-resistant SCLC cell line: alterations in cellular pharmacokinetics and in pattern of cross-resistance by Binaschi, M, Supino, R, Gambetta, R A, Giaccone, G, Prosperi, E, Capranico, G, Cataldo, I, Zunino, F

“…The development of non-P-glycoprotein-mediated multi-drug resistance is a frequent event among lung-cancer cell lines. In an attempt to understand the…”
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Synthesis and Evaluation of New Naphthalene and Naphthoquinone Derivatives as Anticancer Agents by Beretta, Giovanni L., Ribaudo, Giovanni, Menegazzo, Ileana, Supino, Rosanna, Capranico, Giovanni, Zunino, Franco, Zagotto, Giuseppe

“…DNA topoisomerase I inhibitors, both synthetic and of natural origin, are receiving increasing consideration primarily as drugs against refractory tumors…”
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A novel 9-aza-anthrapyrazole effective against human prostatic carcinoma xenografts by Supino, R, Polizzi, D, Pavesi, R, Pratesi, G, Guano, F, Capranico, G, Palumbo, M, Sissi, C, Richter, S, Beggiolin, G, Menta, E, Pezzoni, G, Spinelli, S, Torriani, D, Carenini, N, Dal Bo, L, Facchinetti, F, Tortoreto, M, Zunino, F

“…Systematic investigation of a novel series of intercalating agents, 9-aza-anthrapyrazoles, has led to the identification of a promising analogue, BBR 3438…”
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Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells by Zuco, Valentina, Supino, Rosanna, Righetti, Sabina C, Cleris, Loredana, Marchesi, Edoardo, Gambacorti-Passerini, Carlo, Formelli, Franca

“…Betulinic acid is a triterpene with selective cytotoxicity against melanoma, neuroectodermal and malignant brain tumor cell lines. In this study the betulinic…”
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