Search Results - "Rosania, Gustavo R"

Combinatorial Approach to Organelle-Targeted Fluorescent Library Based on the Styryl Scaffold by Rosania, Gustavo R, Lee, Jae Wook, Ding, Liang, Yoon, Hai-Shin, Chang, Young-Tae

“…The first fluorescent styryl dye library with a broad color range was synthesized by combinatorial condensation of various aldehydes and methyl pyridinium…”
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Expulsion of small molecules in vesicles shed by cancer cells: Association with gene expression and chemosensitivity profiles by SHEDDEN, Kerby, XUE TAO XIE, CHANDAROY, Parthapratim, YOUNG TAE CHANG, ROSANIA, Gustavo R

“…Anticancer drug resistance results from selective pressure of chemotherapy, together with mutations or epigenetic changes that make cells refractory to…”
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A Cyclin-Dependent Kinase Inhibitor Inducing Cancer Cell Differentiation: Biochemical Identification Using Xenopus Egg Extracts by Rosania, Gustavo R., Merlie, John, Gray, Nathanael, Chang, Young-Tae, Schultz, Peter G., Heald, Rebecca

“…Cellular differentiation is a complex process involving growth arrest, exit from the cell cycle, and expression of differentiated cell-type-specific functions…”
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Data Mining the NCI60 to Predict Generalized Cytotoxicity by Lee, Adam C, Shedden, Kerby, Rosania, Gustavo R, Crippen, Gordon M

“…Elimination of cytotoxic compounds in the early and later stages of drug discovery can help reduce the costs of research and development. Through the…”
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Development of novel cell-permeable DNA sensitive dyes using combinatorial synthesis and cell-based screening by Lee, Jae Wook, Jung, Michelle, Rosania, Gustavo R, Chang, Young-Tae

“…A novel cell-permeable DNA fluorescence sensor was developed based on combinatorially-created styryl dyes and cell-based localization screening…”
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A Novel Microtubule Destabilizing Entity from Orthogonal Synthesis of Triazine Library and Zebrafish Embryo Screening by Moon, Ho-Sang, Jacobson, Eric M, Khersonsky, Sonya M, Luzung, Michael R, Walsh, Daniel P, Xiong, Wennan, Lee, Jae Wook, Parikh, Puja B, Lam, Jennifer C, Kang, Tae-Wook, Rosania, Gustavo R, Schier, Alexander F, Chang, Young-Tae

“…The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by…”
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Myoseverin, a microtubule-binding molecule with novel cellular effects by Schultz, Peter G, Rosania, Gustavo R, Chang, Young-Tae, Perez, Omar, Sutherlin, Daniel, Dong, Helin, Lockhart, David J

“…A new microtubule-binding molecule, myoseverin, was identified from a library of 2,6,9-trisubstituted purines in a morphological differentiation screen…”
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Supertargeted chemistry: identifying relationships between molecular structures and their sub-cellular distribution by Rosania, Gustavo R

“…Supertargeted chemistry is the study of how chemical structures localize or direct molecules to specific sub-cellular compartments in living cells…”
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Synthesis and Biological Evaluation of Myoseverin Derivatives:  Microtubule Assembly Inhibitors by Chang, Young-Tae, Wignall, Sarah M, Rosania, Gustavo R, Gray, Nathanael S, Hanson, Sarah R, Su, Andrew I, Merlie, John, Moon, Ho-Sang, Sangankar, Sameep B, Perez, Omar, Heald, Rebecca, Schultz, Peter G

“…Myoseverin, a trisubstituted purine, inhibits microtubule assembly in vitro, interferes with normal mitotic spindle assembly, and arrests the cell cycle in…”
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Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors by Chang, Young-Tae, Gray, Nathanael S, Rosania, Gustavo R, Sutherlin, Daniel P, Kwon, Soojin, Norman, Thea C, Sarohia, Radhika, Leost, Maryse, Meijer, Laurent, Schultz, Peter G

“…Purines constitute a structural class of protein ligands involved in mediating an astonishing array of metabolic processes and signal pathways in all living…”
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A rational approach to personalized anticancer therapy: Chemoinformatic analysis reveals mechanistic gene-drug associations by SHEDDEN, Kerby, TOWNSEND, Leroy B, DRACH, John C, ROSANIA, Gustavo R

“…To predict the response of cells to chemotherapeutic agents based on gene expression profiles, we performed a chemoinformatic study of a set of standard…”
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Chemoinformatic Analysis of a Supertargeted Combinatorial Library of Styryl Molecules by Shedden, Kerby, Brumer, Julie, Chang, Young Tae, Rosania, Gustavo R

“…Styryl dyes are fluorescent, lipophilic cations that have been used as specific labeling probes of mitochondria in living cells. For specific applications such…”
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Effects of Macromolecular Crowding on Nuclear Size by Rosania, Gustavo R., Swanson, Joel A.

“…The concentration of macromolecules inside cells is high, and the resultant crowding of cytoplasm can be expected to affect many interactions involving…”
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Microtubules can modulate pseudopod activity from a distance inside macrophages by Rosania, Gustavo R., Swanson, Joel A.

“…Microtubules are thought to influence cell shape as structural components of an integrated cytoskeletal matrix. Here we show that microtubules can affect the…”
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