Septal medial/diagonal band of Broca citalopram infusion reduces place learning efficiency and alters septohippocampal theta learning-related activity in rats

Septal medial/diagonal band of Broca citalopram infusion reduces place learning efficiency and alters septohippocampal theta learning-related activity in rats

Increases in power and frequency of hippocampal theta activity have been related to efficient place learning and memory acquisition in hippocampal-dependent tests. The complex medial septum-diagonal band of Broca (MS/DBB) is the pacemaker of hippocampal theta activity, influenced by the ascending sy...

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Bibliographic Details
Published in:Behavioural brain research Vol. 435; p. 114056
Main Authors: Hernández, Eduardo Solórzano, Alfaro, José Miguel Cervantes, Rosales, Rosalinda Figueroa, Guzmán, Blanca Erika Gutiérrez, Vázquez, Miguel Ángel López, Cortés, María Esther Olvera
Format: Journal Article
Language:English
Published: Elsevier B.V 28-10-2022
Subjects:
citalopram
hippocampus
MS/DBB
place learning
serotonin
theta activity
serotonin
hippocampus
place learning
citalopram
MS/DBB
theta activity
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Summary:Increases in power and frequency of hippocampal theta activity have been related to efficient place learning and memory acquisition in hippocampal-dependent tests. The complex medial septum-diagonal band of Broca (MS/DBB) is the pacemaker of hippocampal theta activity, influenced by the ascending synchronizing system, and modulated by serotonergic raphe medial afferents, acting on cholinergic and GABAergic septal neurons. The suppression of hippocampal theta expression and the modulation of hippocampal learning and memory are attributed to serotonin. To simultaneously test these hypotheses, a daily local serotonin increase was induced by citalopram (CIT) infusion (100µM, 0.88µL, 0.2µL/m) 15minutes before training in the Morris water maze. The theta activity was recorded in the MS/DBB, dentate gyrus (DG) and CA1 of one group infused with artificial cerebrospinal liquid (ACL) and the other with CIT on Days 1-6 of training. After a probe trial (Day 7) and one resting day, the treatments were reversed (Days 8-11). The CIT MS/DBB infusion in the first 6 training days reduced the efficiency of spatial learning in association with reduced power in the DG, reduced MS/DBB-DG coherence, increased DG-CA1 coherence, and a lack of a negative correlation between MS/DBB power and swam distances. No effect of the CIT occurred once the information was acquired under ACL training. These results support a role of serotonin, in acting on the MS/DBB in the fine tuning of hippocampal learning and memory efficiency through the modulation of learning-related theta activity power and septohipocampal synchronization. •MS/DBB citalopram infusion increases serotonin and modulates place learning accuracy.•MS/DBB citalopram infusion does not affect spatial information retrieval.•MS/DBB citalopram infusion reduces absolute theta power of the dentate gyrus.•MS/DBB-dentate gyrus coherence is reduced by MS/DBB citalopram infusion.•CA1-dentate gyrus coherence is increased after MS/DBB citalopram infusion.
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ISSN:0166-4328
1872-7549
DOI:10.1016/j.bbr.2022.114056