Search Results - "Rosado, Ivan V."

Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen by Pontel, Lucas B., Rosado, Ivan V., Burgos-Barragan, Guillermo, Garaycoechea, Juan I., Yu, Rui, Arends, Mark J., Chandrasekaran, Gayathri, Broecker, Verena, Wei, Wei, Liu, Limin, Swenberg, James A., Crossan, Gerry P., Patel, Ketan J.

“…Endogenous formaldehyde is produced by numerous biochemical pathways fundamental to life, and it can crosslink both DNA and proteins. However, the consequences…”
Get full text

Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice by Langevin, Frédéric, Crossan, Gerry P., Rosado, Ivan V., Arends, Mark J., Patel, Ketan J.

“…Reactive aldehydes are common carcinogens. They are also by-products of several metabolic pathways and, without enzymatic catabolism, may accumulate and cause…”
Get full text

Ku70 Corrupts DNA Repair in the Absence of the Fanconi Anemia Pathway by Pace, Paul, Mosedale, Georgina, Hodskinson, Michael R, Rosado, Ivan V, Sivasubramaniam, Meera, Patel, Ketan J

“…A conserved DNA repair response is defective in the human genetic illness Fanconi anemia (FA). Mutation of some FA genes impairs homologous recombination and…”
Get full text

XRCC1 Prevents Replication Fork Instability during Misincorporation of the DNA Demethylation Bases 5-Hydroxymethyl-2'-Deoxycytidine and 5-Hydroxymethyl-2'-Deoxyuridine by Peña-Gómez, María José, Suárez-Pizarro, Marina, Rosado, Iván V

“…Whilst avoidance of chemical modifications of DNA bases is essential to maintain genome stability, during evolution eukaryotic cells have evolved a chemically…”
Get full text

Multivalent Calixarene-Based Liposomes as Platforms for Gene and Drug Delivery by Lebrón, José Antonio, López-López, Manuel, García-Calderón, Clara B., V. Rosado, Ivan, Balestra, Fernando R., Huertas, Pablo, Rodik, Roman V., Kalchenko, Vitaly I., Bernal, Eva, Moyá, María Luisa, López-Cornejo, Pilar, Ostos, Francisco J.

“…The formation of calixarene-based liposomes was investigated, and the characterization of these nanostructures was carried out using several techniques. Four…”
Get full text

Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia by Patel, Ketan J, Crossan, Gerry P, van der Weyden, Louise, Rosado, Ivan V, Langevin, Frederic, Gaillard, Pierre-Henri L, McIntyre, Rebecca E, Gallagher, Ferdia, Kettunen, Mikko I, Lewis, David Y, Brindle, Kevin, Arends, Mark J, Adams, David J

“…The evolutionarily conserved SLX4 protein, a key regulator of nucleases, is critical for DNA damage response. SLX4 nuclease complexes mediate repair during…”
Get full text

Walker B motif in avian FANCM is required to limit sister chromatid exchanges but is dispensable for DNA crosslink repair by Rosado, Ivan V, Niedzwiedz, Wojciech, Alpi, Arno F, Patel, Ketan J

“…FANCM, the most highly conserved component of the Fanconi Anaemia (FA) pathway can resolve recombination intermediates and remodel synthetic replication forks…”
Get full text

Functional analysis of Saccharomyces cerevisiae ribosomal protein Rpl3p in ribosome synthesis by Rosado, Iván V, Kressler, Dieter, de la Cruz, Jesús

“…Ribosome synthesis in eukaryotes requires a multitude of trans-acting factors. These factors act at many steps as the pre-ribosomal particles travel from the…”
Get full text

The Fanconi Anemia Pathway Protects Genome Integrity from R-loops by García-Rubio, María L, Pérez-Calero, Carmen, Barroso, Sonia I, Tumini, Emanuela, Herrera-Moyano, Emilia, Rosado, Iván V, Aguilera, Andrés

“…Co-transcriptional RNA-DNA hybrids (R loops) cause genome instability. To prevent harmful R loop accumulation, cells have evolved specific eukaryotic factors,…”
Get full text

Metallo-Liposomes Derived from the [Ru(bpy)3]2+ Complex as Nanocarriers of Therapeutic Agents by Moyá, Maria Luisa, Ostos, Francisco José, Moreno, Izamar, García, Diandra, Moreno-Gordillo, Paula, V. Rosado, Ivan, López-Cornejo, Pilar, Lebrón, José Antonio, López-López, Manuel

“…The obtaining of nanocarriers of gene material and small drugs is still an interesting research line. Side-effects produced by the toxicity of several…”
Get full text

Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism by Burgos-Barragan, Guillermo, Wit, Niek, Meiser, Johannes, Dingler, Felix A., Pietzke, Matthias, Mulderrig, Lee, Pontel, Lucas B., Rosado, Ivan V., Brewer, Thomas F., Cordell, Rebecca L., Monks, Paul S., Chang, Christopher J., Vazquez, Alexei, Patel, Ketan J.

“…The folate-driven one-carbon (1C) cycle is a fundamental metabolic hub in cells that enables the synthesis of nucleotides and amino acids and epigenetic…”
Get full text

Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway by Rosado, Ivan V, Langevin, Frédéric, Crossan, Gerry P, Takata, Minoru, Patel, Ketan J

“…The Fanconi anemia (FA) DNA-repair pathway is important in processing of DNA interstrand cross-links and in resistance to exogenously added aldehyde. Genetic…”
Get full text

Final pre-40S maturation depends on the functional integrity of the 60S subunit ribosomal protein L3 by García-Gómez, Juan J, Fernández-Pevida, Antonio, Lebaron, Simon, Rosado, Iván V, Tollervey, David, Kressler, Dieter, de la Cruz, Jesús

“…Ribosomal protein L3 is an evolutionarily conserved protein that participates in the assembly of early pre-60S particles. We report that the rpl3[W255C]…”
Get full text

P‐Sulfocalix[6]arene as Nanocarrier for Controlled Delivery of Doxorubicin by Ostos, Francisco J., Lebrón, José A., Moyá, Maria L., López‐López, Manuel, Sánchez, Antonio, Clavero, Amparo, García‐Calderón, Clara B., Rosado, Iván V., López‐Cornejo, Pilar

“…Given the high toxicity of the anthracycline antibiotic doxorubicin (DOX), it is relevant to search for nanocarriers that decrease the side effects of the drug…”
Get full text

Xpf suppresses the mutagenic consequences of phagocytosis in Dictyostelium by Pontel, Lucas B, Langenick, Judith, Rosado, Ivan V, Zhang, Xiao-Yin, Traynor, David, Kay, Robert R, Patel, Ketan J

“…As time passes, mutations accumulate in the genomes of all living organisms. These changes promote genetic diversity, but also precipitate ageing and the…”
Get full text

FANCD2 maintains replication fork stability during misincorporation of the DNA demethylation products 5-hydroxymethyl-2’-deoxycytidine and 5-hydroxymethyl-2’-deoxyuridine by Peña-Gómez, María José, Moreno-Gordillo, Paula, Narmontė, Milda, García-Calderón, Clara B., Rukšėnaitė, Audronė, Klimašauskas, Saulius, Rosado, Iván V.

“…Fanconi anemia (FA) is a rare hereditary disorder caused by mutations in any one of the FANC genes. FA cells are mainly characterized by extreme…”
Get full text

Sensitivity of hematopoietic stem cells to mitochondrial dysfunction by SdhD gene deletion by Bejarano-García, José Antonio, Millán-Uclés, África, Rosado, Iván V, Sánchez-Abarca, Luís Ignacio, Caballero-Velázquez, Teresa, Durán-Galván, María José, Pérez-Simón, José Antonio, Piruat, José I

“…It is established that hematopoietic stem cells (HSC) in the hypoxic bone marrow have adapted their metabolism to oxygen-limiting conditions. This adaptation…”
Get full text

Characterization of Saccharomyces cerevisiae Npa2p (Urb2p) Reveals a Low-Molecular-Mass Complex Containing Dbp6p, Npa1p (Urb1p), Nop8p, and Rsa3p Involved in Early Steps of 60S Ribosomal Subunit Biogenesis by Rosado, Iván V., Dez, Christophe, Lebaron, Simon, Caizergues-Ferrer, Michèle, Henry, Yves, de la Cruz, Jesús

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Erratum: Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism by Burgos-Barragan, Guillermo, Wit, Niek, Meiser, Johannes, Dingler, Felix A., Pietzke, Matthias, Mulderrig, Lee, Pontel, Lucas B., Rosado, Ivan V., Brewer, Thomas F., Cordell, Rebecca L., Monks, Paul S., Chang, Christopher J., Vazquez, Alexei, Patel, Ketan J.

“…Nature 548, 549–554 (2017); doi:10.1038/nature23481 In this Article, owing to an error during the production process, the keys to the growth curve graphs in…”
Get full text

Genotoxicity of tetrahydrofolic acid to hematopoietic stem and progenitor cells by García-Calderón, Clara B., Bejarano-García, José Antonio, Tinoco-Gago, Isabel, Castro, María José, Moreno-Gordillo, Paula, Piruat, José I., Caballero-Velázquez, Teresa, Pérez-Simón, José A., Rosado, Iván V.

“…Metabolically reactive formaldehyde is a genotoxin and a carcinogen. Mice lacking the main formaldehyde-detoxifying gene Adh5 combined with the loss of the…”
Get full text