Search Results - "Rosada, Cecilia"

Leptin deficiency in mice counteracts imiquimod (IMQ)‐induced psoriasis‐like skin inflammation while leptin stimulation induces inflammation in human keratinocytes by Stjernholm, Theresa, Ommen, Pernille, Langkilde, Ane, Johansen, Claus, Iversen, Lars, Rosada, Cecilia, Stenderup, Karin

“…Leptin is an adipocyte‐derived cytokine secreted mostly by adipose tissue. Serum leptin levels are elevated in obese individuals and correlate positively with…”
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Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells by Kassem, Moustapha, Simonsen, Janne L, Rosada, Cecilia, Serakinci, Nedime, Justesen, Jeannette, Stenderup, Karin, Rattan, Suresh I.S, Jensen, Thomas G

“…Human bone marrow stromal cells (hMSCs) were stably transduced by a retroviral vector containing the gene for the catalytic subunit of human telomerase…”
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Psoriasiform skin disease in transgenic pigs with high-copy ectopic expression of human integrins α2 and β1 by Staunstrup, Nicklas Heine, Stenderup, Karin, Mortensen, Sidsel, Primo, Maria Nascimento, Rosada, Cecilia, Steiniche, Torben, Liu, Ying, Li, Rong, Schmidt, Mette, Purup, Stig, Dagnæs-Hansen, Frederik, Schrøder, Lisbeth Dahl, Svensson, Lars, Petersen, Thomas Kongstad, Callesen, Henrik, Bolund, Lars, Mikkelsen, Jacob Giehm

“…Psoriasis is a complex human-specific disease characterized by perturbed keratinocyte proliferation and a pro-inflammatory environment in the skin. Porcine…”
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Interleukin-20 as a Target in Psoriasis Treatment by STENDERUP, KARIN, ROSADA, CECILIA, WORSAAE, ANNE, CLAUSEN, JES THORN, NORMAN DAM, TOMAS

“…:  Interleukin‐20 (IL‐20) is a new member of the IL‐10 cytokine family discovered by a structural algorithm. IL‐20 transgenic mice displayed skin abnormalities…”
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Exploring valrubicin’s effect on Propionibacterium acnes-induced skin inflammation in vitro and in vivo by Rottboell, Louise, De Foenss, Sarah, Thomsen, Kenneth, Christiansen, Helle, Andersen, Stine M., Dam, Thomas N., Rosada, Cecilia, Stenderup, Karin

“…Acne is a common skin disease involving colonization with Propionibacterium acnes (P. acnes), hyperproliferation of the follicular epithelium and inflammatory…”
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Langerhans cell markers CD1a and CD207 are the most rapidly responding genes in lesional psoriatic skin following adalimumab treatment by Raaby, Line, Rosada, Cecilia, Langkilde, Ane, Lauridsen, Kristina Lystlund, Vinter, Hanne, Ommen, Pernille, Kjellerup, Rasmus Boye, Johansen, Claus, Iversen, Lars

“…TNFα‐, IL‐23‐ and IL‐17‐targeting drugs are highly effective in the treatment of psoriasis. However, the precise molecular mechanism remains unknown. In…”
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Activation and inhibition of the C-terminal kinase domain of p90 ribosomal S6 kinases by Fruergaard, Marlene Uglebjerg, Nielsen, Christine Juul Fælled, Kjeldsen, Cecilia Rosada, Iversen, Lars, Andersen, Jacob Lauwring, Nissen, Poul

“…The p90 ribosomal S6 kinases (RSKs) contain two distinct catalytic kinase domains, the N-terminal and C-terminal kinase domains (NTKD and CTKD, respectively)…”
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Amelioration of Psoriasis by Anti-TNF-α RNAi in the Xenograft Transplantation Model by Jakobsen, Maria, Stenderup, Karin, Rosada, Cecilia, Moldt, Brian, Kamp, Søren, Dam, Tomas N, Jensen, Thomas G, Mikkelsen, Jacob Giehm

“…Tumor necrosis factor-α (TNF-α) is upregulated in psoriatic skin and represents a prominent target in psoriasis treatment. The level of TNF-α-encoding mRNA,…”
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Langerhans cell markers CD 1a and CD 207 are the most rapidly responding genes in lesional psoriatic skin following adalimumab treatment by Raaby, Line, Rosada, Cecilia, Langkilde, Ane, Lauridsen, Kristina Lystlund, Vinter, Hanne, Ommen, Pernille, Kjellerup, Rasmus Boye, Johansen, Claus, Iversen, Lars

“…Abstract TNF α‐, IL ‐23‐ and IL ‐17‐targeting drugs are highly effective in the treatment of psoriasis. However, the precise molecular mechanism remains…”
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Relationship between CD44 expression and cell proliferation in epithelium and stroma of colorectal neoplasms by Furuta, K, Zahurak, M, Yang, XL, Rosada, C, Goodman, SN, August, JT, Hamilton, SR

“…The cell surface glycoprotein CD44 is expressed primarily in the region of cell replication in the lower crypt epithelium of colorectal mucosa, and its…”
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Debio 0932, a new oral Hsp90 inhibitor, alleviates psoriasis in a xenograft transplantation model by Stenderup, Karin, Rosada, Cecilia, Gavillet, Bruno, Vuagniaux, Grégoire, Dam, Tomas Norman

“…Debio 0932 is a novel oral heat shock protein 90 (Hsp90) inhibitor developed for anti-cancer therapy. Surprising-ly, during the first clinical trial, one…”
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Resolution of Psoriasis by a Leukocyte-Targeting Bacterial Protein in a Humanized Mouse Model by Stenderup, Karin, Rosada, Cecilia, Dam, Thomas N., Salerno, Erica, Belinka, Benjamin A., Kachlany, Scott C.

“…Psoriasis is a very common chronic skin disease, affecting 2–3% of the world's population or more than 125 million individuals worldwide. The characteristic…”
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AZ17: a new bispecific drug targeting IL-6 and IL-23 with potential clinical use—improves psoriasis in a human xenograft transplantation model by Stenderup, Karin, Rosada, Cecilia, Shanebeck, Kurt, Brady, William, Van Brunt, Michael P., King, Gordon, Marelli, Marcello, Slagle, Paul, Xu, Hengyu, Nairn, Natalie W., Johnson, Jeffrey, Wang, Aijun A., Li, Gary, Thornton, Kenneth C., Dam, Tomas N., Grabstein, Kenneth H.

“…Targeting more than one molecule in multifactorial diseases involving several disease mediators may provide improved therapeutic efficacy. Psoriasis is a…”
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Valrubicin in a Topical Formulation Treats Psoriasis in a Xenograft Transplantation Model by Rosada, Cecilia, Stenderup, Karin, de Darkó, Elisabeth, Dagnaes-Hansen, Frederik, Kamp, Søren, Dam, Tomas Norman

“…Valrubicin is a cytostatic drug currently approved by the American Federal Drug Administration as a trademarked Valstar sterile solution for the treatment of…”
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A lentiviral vector-based genetic sensor system for comparative analysis of permeability and activity of vitamin D3 analogues in xenotransplanted human skin by Staunstrup, Nicklas Heine, Bak, Rasmus O., Cai, Yujia, Svensson, Lars, Petersen, Thomas K., Rosada, Cecilia, Stenderup, Karin, Bolund, Lars, Mikkelsen, Jacob Giehm

“…Vitamin D3 analogues are widely used topical and oral remedies for various ailments such as psoriasis, osteoporosis and secondary hyperparathyroidism. In…”
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Valrubicin activates PKCa in keratinocytes: a conceivable mode of action in treating hyper-proliferative skin diseases by Laugesen, Ina Groenkjaer, Hauge, Eva, Andersen, Stine Maria, Stenderup, Karin, de Darkó, Elisabeth, Dam, Tomas Norman, Rosada, Cecilia

“…Valrubicin is a semisynthetic anthracycline developed as an anti-cancer drug able to ameliorate psoriasis and non-melanoma skin cancer (NMSC) by topical…”
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Statistical evaluation and experimental design of a psoriasis xenograft transplantation model treated with cyclosporin A: Statistical evaluation of psoriasis xenograft transplantation model by Stenderup, Karin, Rosada, Cecilia, Alifrangis, Lene, Andersen, Søren, Dam, Tomas Norman

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Topical application of valrubicin has a beneficial effect on developing skin tumors by Andersen, Stine M., Rosada, Cecilia, Dagnaes-Hansen, Frederik, Laugesen, Ina G., de Darkó, Elisabeth, Dam, Tomas N., Stenderup, Karin

“…Valrubicin is a second generation anthracycline characterized by an excellent safety profile presenting no skin toxicity or necrosis upon contact. In its…”
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Statistical evaluation and experimental design of a psoriasis xenograft transplantation model treated with cyclosporin A by Stenderup, Karin, Rosada, Cecilia, Alifrangis, Lene, Andersen, Søren, Dam, Tomas Norman

“…:  Psoriasis xenograft transplantation models where human skin is transplanted onto immune‐deficient mice are generally accepted in psoriasis research. Over…”
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Robust Lentiviral Gene Delivery But Limited Transduction Capacity of Commonly Used Adeno-Associated Viral Serotypes in Xenotransplanted Human Skin by Jakobsen, Maria, Askou, Anne Louise, Stenderup, Karin, Rosada, Cecilia, Dagnæs-Hansen, Frederik, Jensen, Thomas G, Corydon, Thomas J, Mikkelsen, Jacob Giehm, Aagaard, Lars

“…Skin is an easily accessible organ, and therapeutic gene transfer to skin remains an attractive alternative for the treatment of skin diseases. Although we…”
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