Serological and Molecular Evidence of the Circulation of the Venezuelan Equine Encephalitis Virus Subtype IIIA in Humans, Wild Vertebrates and Mosquitos in the Brazilian Amazon

Serological and Molecular Evidence of the Circulation of the Venezuelan Equine Encephalitis Virus Subtype IIIA in Humans, Wild Vertebrates and Mosquitos in the Brazilian Amazon

Understanding the interaction between viruses and ecosystems in areas with or without anthropic interference can contribute to the organization of public health services, as well as prevention and disease control. An arbovirus survey was conducted at Caxiuanã National Forest, Pará, Brazil, where 632...

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Bibliographic Details
Published in:Viruses Vol. 14; no. 11; p. 2391
Main Authors: Silva, Franko A, Ferreira, Milene S, Araújo, Pedro A, Casseb, Samir M M, Silva, Sandro P, Nunes Neto, Joaquim P, Chiang, Jannifer O, Rosa Junior, José W, Chagas, Liliane L, Freitas, Maria N O, Santos, Éder B, Hernández, Leonardo, Paz, Thito, Vasconcelos, Pedro F C, Martins, Lívia C
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 28-10-2022
MDPI
Subjects:
Age
Alphavirus
Animals
Antibodies
arbovirus
Arboviruses
Arthropods
Brazil - epidemiology
Cluster analysis
Culicidae
Disease control
Diseases
Distribution
Ecological studies
Ecosystem
Encephalitis
Encephalitis Virus, Venezuelan Equine - genetics
Genomes
Health aspects
Horses
Humans
Maximum likelihood method
metagenomic
Mucambo virus
Phylogenetics
Population
Public health
Serology
Urban environments
Venezuelan equine encephalitis
Vertebrates
Viruses
Brazil
United States > US
Amazon Basin
metagenomic
Mucambo virus
arbovirus
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Summary:Understanding the interaction between viruses and ecosystems in areas with or without anthropic interference can contribute to the organization of public health services, as well as prevention and disease control. An arbovirus survey was conducted at Caxiuanã National Forest, Pará, Brazil, where 632 local residents, 338 vertebrates and 15,774 pools of hematophagous arthropods were investigated. Neutralization antibodies of the Venezuelan Equine Encephalitis virus, subtype IIIA, Mucambo virus (MUCV) were detected in 57.3% and 61.5% of humans and wild vertebrates, respectively; in addition, genomic fragments of MUCV were detected in pool of . The obtained data suggest an enzootic circulation of MUCV in the area. Understanding the circulation of endemic and neglected arboviruses, such as MUCV, represents an important health problem for the local residents and for the people living in the nearby urban centers.
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ISSN:1999-4915
1999-4915
DOI:10.3390/v14112391