Search Results - "Rosa, Julia"
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Creatine, Similar to Ketamine, Counteracts Depressive-Like Behavior Induced by Corticosterone via PI3K/Akt/mTOR Pathway
Published in Molecular neurobiology (01-12-2016)“…Ketamine has emerged as a novel strategy to treat refractory depression, producing rapid remission, but elicits some side effects that limit its use. In an…”
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Subthreshold doses of guanosine plus ketamine elicit antidepressant-like effect in a mouse model of depression induced by corticosterone: Role of GR/NF-κB/IDO-1 signaling
Published in Neurochemistry international (01-10-2020)“…Augmentative treatment is considered the best second-option when a first-choice drug has partial limitations, particularly by allowing antidepressant dose…”
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mTORC1-dependent signaling pathway underlies the rapid effect of creatine and ketamine in the novelty-suppressed feeding test
Published in Chemico-biological interactions (01-12-2020)“…The development of fast-acting antidepressants is crucial considering that conventional antidepressants require a long period to elicit therapeutic effects…”
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Evidence that the anti‐inflammatory effect of 4‐aryl‐4H‐chromenes is linked to macrophage repolarization
Published in Fundamental & clinical pharmacology (01-12-2022)“…The inflammatory response is a common feature of many pathological conditions, and there is urgent necessity for new substances that minimize the harmful…”
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In vitro evidence that the anti‐inflammatory effect of synthetic cinnamate‐derived dienes is directly linked to a macrophage repolarization
Published in Fundamental & clinical pharmacology (01-10-2022)“…The inflammatory process is a mammalian physiological reaction against infectious agents or injuries. Among the cells involved, the macrophages have a…”
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The Role of MicroRNA and Microbiota in Depression and Anxiety
Published in Frontiers in behavioral neuroscience (01-03-2022)“…Depression and anxiety are devastating disorders. Understanding the mechanisms that underlie the development of depression and anxiety can provide new hints on…”
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Interference in Macrophage Balance (M1/M2): The Mechanism of Action Responsible for the Anti-Inflammatory Effect of a Fluorophenyl-Substituted Imidazole
Published in Mediators of inflammation (2024)“…Traditionally, the treatment of inflammatory conditions has focused on the inhibition of inflammatory mediator production; however, many conditions are…”
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Augmentation effect of ketamine by guanosine in the novelty-suppressed feeding test is dependent on mTOR signaling pathway
Published in Journal of psychiatric research (01-08-2019)“…The ketamine's potential for the treatment of refractory depression and anxiety has been considered one the most important discoveries in the last years,…”
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Prophylactic effect of physical exercise on Aβ 1-40 -induced depressive-like behavior: Role of BDNF, mTOR signaling, cell proliferation and survival in the hippocampus
Published in Progress in neuro-psychopharmacology & biological psychiatry (30-08-2019)“…Alzheimer's disease (AD) is characterized by progressive cognitive impairments as well as non-cognitive symptoms such as depressed mood. Physical exercise has…”
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Prophylactic effect of physical exercise on Aβ1–40-induced depressive-like behavior: Role of BDNF, mTOR signaling, cell proliferation and survival in the hippocampus
Published in Progress in neuro-psychopharmacology & biological psychiatry (30-08-2019)“…Alzheimer's disease (AD) is characterized by progressive cognitive impairments as well as non-cognitive symptoms such as depressed mood. Physical exercise has…”
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Low doses of ketamine and guanosine abrogate corticosterone-induced anxiety-related behavior, but not disturbances in the hippocampal NLRP3 inflammasome pathway
Published in Psychopharmacology (01-09-2021)“…Rationale Guanosine has been shown to potentiate ketamine’s antidepressant-like actions, although its ability to augment the anxiolytic effect of ketamine…”
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The relationship between peripheral immune response and disease severity in SARS‐CoV‐2‐infected subjects: A cross‐sectional study
Published in Immunology (01-04-2022)“…Coronavirus disease 2019 (COVID‐19) is a respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and marked by an intense…”
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Anxiolytic-like effects of ursolic acid in mice
Published in European journal of pharmacology (05-07-2015)“…Ursolic acid is a pentacyclic triterpenoid that possesses several biological and neuropharmacological effects including antidepressant-like activity. Anxiety…”
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Effect of gold and graphene oxide nanoparticles on the thermo- and photo-actuation of monodomain liquid crystal elastomers
Published in Polymer (Guilford) (28-09-2020)“…Monodomain liquid crystal elastomers (m-LCEs) were synthesized from polymethylhydrosiloxane (PMHS), two distinct vinyl-functionalized mesogens (benzoate and…”
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Sequential administration of paricalcitol followed by IL-17 blockade for progressive refractory IgA nephropathy patients
Published in Scientific reports (28-02-2024)“…There is no established treatment for progressive IgA nephropathy refractory to steroids and immunosuppressant drugs (r-IgAN). Interleukin 17 (IL-17) blockade…”
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Enhancement of the photoinduced birefringence and inverse relaxation of a liquid crystal azopolymer by doping with carbon nanostructures
Published in Journal of photochemistry and photobiology. A, Chemistry. (01-02-2023)“…[Display omitted] •Carbon nanotubes can enhance the photoinduced birefringence of azopolymers.•The in situ doping method provides a good polymer-nanotube…”
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T cell maturation is significantly affected by SARS‐CoV‐2 infection
Published in Immunology (01-07-2023)“…Coronavirus disease 2019 (COVID‐19) is a respiratory tract infection caused by the new severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). An…”
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Plasma from patients undergoing allogeneic hematopoietic stem cell transplantation promotes NETOSIS in vitro and correlates with inflammatory parameters and clinical severity
Published in Frontiers in immunology (14-03-2024)“…NETosis, the mechanism by which neutrophils release extracellular traps (NETs), is closely related to inflammation. During the allogeneic hematopoietic stem…”
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Anti-NMDAR antibodies in new-onset psychosis. Positive results in an HIV-infected patient
Published in Brain, behavior, and immunity (01-08-2016)“…Highlights • Neuronal surface antibodies (NSAs) were tested in 61 new-onset psychosis patients. • A positive case for NASs in a non-encephalitic psychosis is…”
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Dispersal of thermophilic Desulfotomaculum endospores into Baltic Sea sediments over thousands of years
Published in The ISME Journal (01-01-2013)“…Patterns of microbial biogeography result from a combination of dispersal, speciation and extinction, yet individual contributions exerted by each of these…”
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