Search Results - "Rosa, Juan Manuel Rosa"

Extensive scar formation and regression during heart regeneration after cryoinjury in zebrafish by González-Rosa, Juan Manuel, Martín, Víctor, Peralta, Marina, Torres, Miguel, Mercader, Nadia

“…The zebrafish heart has the capacity to regenerate after ventricular resection. Although this regeneration model has proved useful for the elucidation of…”
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Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish by González-Rosa, Juan Manuel, Sharpe, Michka, Field, Dorothy, Soonpaa, Mark H., Field, Loren J., Burns, Caroline E., Burns, C. Geoffrey

“…Correlative evidence suggests that polyploidization of heart muscle, which occurs naturally in post-natal mammals, creates a barrier to heart regeneration…”
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Molecular Basis of Tumor Heterogeneity in Endometrial Carcinosarcoma by Leskela, Susanna, Pérez-Mies, Belen, Rosa-Rosa, Juan Manuel, Cristobal, Eva, Biscuola, Michele, Palacios-Berraquero, María L, Ong, SuFey, Matias-Guiu Guia, Xavier, Palacios, José

“…Endometrial carcinosarcoma (ECS) represents one of the most extreme examples of tumor heterogeneity among human cancers. ECS is a clinically aggressive,…”
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Zebrafish heart regeneration: 15 years of discoveries by González‐Rosa, Juan Manuel, Burns, Caroline E., Burns, C. Geoffrey

“…Cardiovascular disease is the leading cause of death worldwide. Compared to other organs such as the liver, the adult human heart lacks the capacity to…”
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A comprehensive analysis of candidate genes in familial pancreatic cancer families reveals a high frequency of potentially pathogenic germline variants by Earl, Julie, Galindo-Pumariño, Cristina, Encinas, Jessica, Barreto, Emma, Castillo, Maria E., Pachón, Vanessa, Ferreiro, Reyes, Rodríguez-Garrote, Mercedes, González-Martínez, Silvia, Ramon y Cajal, Teresa, Diaz, Luis Robles, Chirivella-Gonzalez, Isabel, Rodriguez, Montse, de Castro, Eva Martínez, García-Seisdedos, David, Muñoz, Gloria, Rosa, Juan Manuel Rosa, Marquez, Mirari, Malats, Nuría, Carrato, Alfredo

“…The 5-year survival rate of patients with pancreatic ductal adenocarcinoma (PDAC) is around 5% due to the fact that the majority of patients present with…”
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Zebrafish as a high throughput model for organ preservation and transplantation research by Da Silveira Cavalcante, Luciana, Lopera Higuita, Manuela, González‐Rosa, Juan Manuel, Marques, Beatriz, To, Samantha, Pendexter, Casie A., Cronin, Stephanie E. J., Gopinathan, Kaustav A., Vries, Reinier J., Ellett, Felix, Uygun, Korkut, Langenau, David M., Toner, Mehmet, Tessier, Shannon N.

“…Despite decades of effort, the preservation of complex organs for transplantation remains a significant barrier that exacerbates the organ shortage crisis…”
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Cryoinjury as a myocardial infarction model for the study of cardiac regeneration in the zebrafish by González-Rosa, Juan Manuel, Mercader, Nadia

“…The zebrafish heart has the capacity to regenerate after ventricular resection. Although this regeneration model has proved useful for the elucidation of…”
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Detection of kinase domain mutations in BCR::ABL1 leukemia by ultra-deep sequencing of genomic DNA by Sánchez, Ricardo, Dorado, Sara, Ruíz-Heredia, Yanira, Martín-Muñoz, Alejandro, Rosa-Rosa, Juan Manuel, Ribera, Jordi, García, Olga, Jimenez-Ubieto, Ana, Carreño-Tarragona, Gonzalo, Linares, María, Rufián, Laura, Juárez, Alexandra, Carrillo, Jaime, Espino, María José, Cáceres, Mercedes, Expósito, Sara, Cuevas, Beatriz, Vanegas, Raúl, Casado, Luis Felipe, Torrent, Anna, Zamora, Lurdes, Mercadal, Santiago, Coll, Rosa, Cervera, Marta, Morgades, Mireia, Hernández-Rivas, José Ángel, Bravo, Pilar, Serí, Cristina, Anguita, Eduardo, Barragán, Eva, Sargas, Claudia, Ferrer-Marín, Francisca, Sánchez-Calero, Jorge, Sevilla, Julián, Ruíz, Elena, Villalón, Lucía, del Mar Herráez, María, Riaza, Rosalía, Magro, Elena, Steegman, Juan Luis, Wang, Chongwu, de Toledo, Paula, García-Gutiérrez, Valentín, Ayala, Rosa, Ribera, Josep-Maria, Barrio, Santiago, Martínez-López, Joaquín

“…The screening of the BCR::ABL1 kinase domain (KD) mutation has become a routine analysis in case of warning/failure for chronic myeloid leukemia (CML) and…”
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Heartbeat-Driven Pericardiac Fluid Forces Contribute to Epicardium Morphogenesis by Peralta, Marina, Steed, Emily, Harlepp, Sébastien, González-Rosa, Juan Manuel, Monduc, Fabien, Ariza-Cosano, Ana, Cortés, Alfonso, Rayón, Teresa, Gómez-Skarmeta, Jose-Luis, Zapata, Agustín, Vermot, Julien, Mercader, Nadia

“…Hydrodynamic forces play a central role in organ morphogenesis. The role of blood flow in shaping the developing heart is well established, but the role of…”
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Whole exome sequencing suggests much of non-BRCA1/BRCA2 familial breast cancer is due to moderate and low penetrance susceptibility alleles by Gracia-Aznarez, Francisco Javier, Fernandez, Victoria, Pita, Guillermo, Peterlongo, Paolo, Dominguez, Orlando, de la Hoya, Miguel, Duran, Mercedes, Osorio, Ana, Moreno, Leticia, Gonzalez-Neira, Anna, Rosa-Rosa, Juan Manuel, Sinilnikova, Olga, Mazoyer, Sylvie, Hopper, John, Lazaro, Conchi, Southey, Melissa, Odefrey, Fabrice, Manoukian, Siranoush, Catucci, Irene, Caldes, Trinidad, Lynch, Henry T, Hilbers, Florentine S M, van Asperen, Christi J, Vasen, Hans F A, Goldgar, David, Radice, Paolo, Devilee, Peter, Benitez, Javier

“…The identification of the two most prevalent susceptibility genes in breast cancer, BRCA1 and BRCA2, was the beginning of a sustained effort to uncover new…”
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Notch and Bmp signaling pathways act coordinately during the formation of the proepicardium by Andrés‐Delgado, Laura, Galardi‐Castilla, María, Münch, Juliane, Peralta, Marina, Ernst, Alexander, González‐Rosa, Juan Manuel, Tessadori, Federico, Santamaría, Luis, Bakkers, Jeroen, Vermot, Julien, Pompa, José Luis, Mercader, Nadia

“…Background The epicardium is the outer mesothelial layer of the heart. It encloses the myocardium and plays key roles in heart development and regeneration. It…”
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High Frequency of ERBB2 Activating Mutations in Invasive Lobular Breast Carcinoma with Pleomorphic Features by Rosa-Rosa, Juan Manuel, Caniego-Casas, Tamara, Leskela, Susanna, Cristobal, Eva, González-Martínez, Silvia, Moreno-Moreno, Esther, López-Miranda, Elena, Holgado, Esther, Pérez-Mies, Belén, Garrido, Pilar, Palacios, José

“…Characterisation of molecular alterations of pleomorphic lobular carcinoma (PLC), an aggressive subtype of invasive lobular carcinoma (ILC), have not been yet…”
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Transient fibrosis resolves via fibroblast inactivation in the regenerating zebrafish heart by Sánchez-Iranzo, Héctor, Galardi-Castilla, María, Sanz-Morejón, Andrés, González-Rosa, Juan Manuel, Costa, Ricardo, Ernst, Alexander, de Aja, Julio Sainz, Langa, Xavier, Mercader, Nadia

“…In the zebrafish (Danio rerio), regeneration and fibrosis after cardiac injury are not mutually exclusive responses. Upon cardiac cryoinjury, collagen and…”
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VGLL1 expression is associated with a triple-negative basal-like phenotype in breast cancer by Castilla, María Ángeles, López-García, María Ángeles, Atienza, María Reina, Rosa-Rosa, Juan Manuel, Díaz-Martín, Juan, Pecero, María Luisa, Vieites, Begoña, Romero-Pérez, Laura, Benítez, Javier, Calcabrini, Annarica, Palacios, José

“…Vestigial-like 1 (VGLL1) is a poorly characterized gene encoding a transcriptional co-activator structurally homologous to TAZ and YAP that modulates the Hippo…”
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Treating KRAS-mutant NSCLC: latest evidence and clinical consequences by Garrido, Pilar, Olmedo, María Eugenia, Gómez, Ana, Paz Ares, Luis, López-Ríos, Fernando, Rosa-Rosa, Juan Manuel, Palacios, José

“…KRAS mutations represent one of the most prevalent oncogenic driver mutations in non-small cell lung cancer (NSCLC). For many years we have unsuccessfully…”
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Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration by Sánchez-Iranzo, Héctor, Galardi-Castilla, María, Minguillón, Carolina, Sanz-Morejón, Andrés, González-Rosa, Juan Manuel, Felker, Anastasia, Ernst, Alexander, Guzmán-Martínez, Gabriela, Mosimann, Christian, Mercader, Nadia

“…During development, mesodermal progenitors from the first heart field (FHF) form a primitive cardiac tube, to which progenitors from the second heart field…”
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Telomerase Is Essential for Zebrafish Heart Regeneration by Bednarek, Dorota, González-Rosa, Juan Manuel, Guzmán-Martínez, Gabriela, Gutiérrez-Gutiérrez, Óscar, Aguado, Tania, Sánchez-Ferrer, Carlota, Marques, Inês João, Galardi-Castilla, María, de Diego, Irene, Gómez, Manuel José, Cortés, Alfonso, Zapata, Agustín, Jiménez-Borreguero, Luis Jesús, Mercader, Nadia, Flores, Ignacio

“…After myocardial infarction in humans, lost cardiomyocytes are replaced by an irreversible fibrotic scar. In contrast, zebrafish hearts efficiently regenerate…”
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P840: ASSESSMENT OF CONVENTIONAL TRANSLOCATIONS AND IG REARRANGEMENTS IN THE DIAGNOSIS OF MULTIPLE MYELOMA PATIENTS USING A TARGETED CAPTURE‐HYBRIDIZATION RNA SEQUENCING PANEL by Buenache Cuenda, Natalia, Sánchez, Ricardo, Giménez Sánchez, Alicia, Carneros Blanco, Laura, Alonso Fernández, Rafael, Pina, José María Sánchez, Rapado Martínez, Inmaculada, Ayala Diaz, Rosa, Martinez‐Lopez, Joaquín, Rosa, Juan Manuel Rosa

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Pleomorphic lobular carcinoma of the breast with osteoclast-like giant cells: a case report and review of the literature by Peña-Jaimes, Lourdes, González-García, Irene, Reguero-Callejas, María Eugenia, Pinilla-Pagnon, Ignacio, Pérez-Mies, Belén, Albarrán-Artahona, Víctor, Martínez-Jañez, Noelia, Rosa-Rosa, Juan Manuel, Palacios, José

“…Breast carcinoma with osteoclast-like giant cells (OGCs) is infrequent, being most reported cased described as ductal invasive carcinomas. Invasive pleomorphic…”
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NGS-Based Molecular Karyotyping of Multiple Myeloma: Results from the GEM12 Clinical Trial by Rosa-Rosa, Juan Manuel, Cuenca, Isabel, Medina, Alejandro, Vázquez, Iria, Sánchez-delaCruz, Andrea, Buenache, Natalia, Sánchez, Ricardo, Jiménez, Cristina, Rosiñol, Laura, Gutiérrez, Norma C., Ruiz-Heredia, Yanira, Barrio, Santiago, Oriol, Albert, Martin-Ramos, Maria-Luisa, Blanchard, María-Jesús, Ayala, Rosa, Ríos-Tamayo, Rafael, Sureda, Anna, Hernández, Miguel-Teodoro, de la Rubia, Javier, Alkorta-Aranburu, Gorka, Agirre, Xabier, Bladé, Joan, Mateos, María-Victoria, Lahuerta, Juan-José, San-Miguel, Jesús F., Calasanz, María-José, Garcia-Sanz, Ramón, Martínez-Lopez, Joaquín

“…Next-generation sequencing (NGS) has greatly improved our ability to detect the genomic aberrations occurring in multiple myeloma (MM); however, its transfer…”
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