Search Results - "Rosa, José Luís"

Extracellular calcium promotes bone formation from bone marrow mesenchymal stem cells by amplifying the effects of BMP-2 on SMAD signalling by Aquino-Martínez, Rubén, Artigas, Natalia, Gámez, Beatriz, Rosa, José Luis, Ventura, Francesc

“…Understanding the molecular events that regulate osteoblast differentiation is essential for the development of effective approaches to bone regeneration. In…”
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Mitogen-activated Protein Kinase (MAPK)-regulated Interactions between Osterix and Runx2 Are Critical for the Transcriptional Osteogenic Program by Artigas, Natalia, Ureña, Carlos, Rodríguez-Carballo, Edgardo, Rosa, José Luis, Ventura, Francesc

“…The transcription factors Runx2 and Osx (Osterix) are required for osteoblast differentiation and bone formation. Runx2 expression occurs at early stages of…”
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p53 inhibits SP7/Osterix activity in the transcriptional program of osteoblast differentiation by Artigas, Natalia, Gámez, Beatriz, Cubillos-Rojas, Mónica, Sánchez-de Diego, Cristina, Valer, José Antonio, Pons, Gabriel, Rosa, José Luis, Ventura, Francesc

“…Osteoblast differentiation is achieved by activating a transcriptional network in which Dlx5 , Runx2 and Osx/SP7 have fundamental roles. The tumour suppressor…”
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Wildcat population density in NE Portugal: A regional stronghold for a nationally threatened felid by Matias, Gonçalo, Rosalino, Luís Miguel, Rosa, José Luís, Monterroso, Pedro

“…Population density data on depleted and endangered wildlife species are essential to assure their effective management and, ultimately, conservation. The…”
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Inhibition of phosphatidylinositol 3‐kinase α (PI3Kα) prevents heterotopic ossification by Valer, José Antonio, Sánchez‐de‐Diego, Cristina, Gámez, Beatriz, Mishina, Yuji, Rosa, José Luis, Ventura, Francesc

“…Heterotopic ossification (HO) is the pathological formation of ectopic endochondral bone within soft tissues. HO occurs following mechanical trauma, burns, or…”
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Liraglutide improves liver microvascular dysfunction in cirrhosis: Evidence from translational studies by de Mesquita, Fernanda Cristina, Guixé-Muntet, Sergi, Fernández-Iglesias, Anabel, Maeso-Díaz, Raquel, Vila, Sergi, Hide, Diana, Ortega-Ribera, Martí, Rosa, José Luís, García-Pagán, Juan Carlos, Bosch, Jaime, de Oliveira, Jarbas Rodrigues, Gracia-Sancho, Jordi

“…Hepatic stellate cells (HSC) play a key role in the development of chronic liver disease (CLD). Liraglutide, well-established in type 2 diabetes, showed…”
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Interplay between BMPs and Reactive Oxygen Species in Cell Signaling and Pathology by Sánchez-de-Diego, Cristina, Valer, José Antonio, Pimenta-Lopes, Carolina, Rosa, José Luis, Ventura, Francesc

“…The integration of cell extrinsic and intrinsic signals is required to maintain appropriate cell physiology and homeostasis. Bone morphogenetic proteins (BMPs)…”
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A nonsense variant in HERC1 is associated with intellectual disability, megalencephaly, thick corpus callosum and cerebellar atrophy by Nguyen, Lam Son, Schneider, Taiane, Rio, Marlène, Moutton, Sébastien, Siquier-Pernet, Karine, Verny, Florine, Boddaert, Nathalie, Desguerre, Isabelle, Munich, Arnold, Rosa, José Luis, Cormier-Daire, Valérie, Colleaux, Laurence

“…Megalencephaly is a congenital condition characterized by severe overdeveloped brain size. This phenotype is often caused by mutations affecting the…”
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BMP2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activity by Gamell, Cristina, Osses, Nelson, Bartrons, Ramon, Rückle, Thomas, Camps, Montserrat, Rosa, José Luis, Ventura, Francesc

“…Bone morphogenetic proteins (BMPs) are potent regulators of several cellular events. We report that exposure of C2C12 cells to BMP2 leads to an increase in…”
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Conserved regulatory motifs in osteogenic gene promoters integrate cooperative effects of canonical Wnt and BMP pathways by Rodríguez‐Carballo, Edgardo, Ulsamer, Arnau, Susperregui, Antonio RG, Manzanares‐Céspedes, Cristina, Sánchez‐García, Eva, Bartrons, Ramon, Rosa, José Luis, Ventura, Francesc

“…Osteoblast differentiation depends on the coordinated network of evolutionary conserved transcription factors during bone formation and homeostasis. Evidence…”
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Class I PI‐3‐Kinase Signaling Is Critical for Bone Formation Through Regulation of SMAD1 Activity in Osteoblasts by Gámez, Beatriz, Rodríguez‐Carballo, Edgardo, Graupera, Mariona, Rosa, José Luis, Ventura, Francesc

“…ABSTRACT Bone formation and homeostasis is carried out by osteoblasts, whose differentiation and activity are regulated by osteogenic signaling networks. A…”
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p38 Regulates Expression of Osteoblast-specific Genes by Phosphorylation of Osterix by Ortuño, María José, Ruiz-Gaspà, Silvia, Rodríguez-Carballo, Edgardo, Susperregui, Antonio R.G., Bartrons, Ramon, Rosa, José Luis, Ventura, Francesc

“…Osterix, a zinc finger transcription factor, is specifically expressed in osteoblasts and osteocytes of all developing bones. Because no bone formation occurs…”
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Osterix induces Col1a1 gene expression through binding to Sp1 sites in the bone enhancer and proximal promoter regions by Ortuño, Maria José, Susperregui, Antonio R.G, Artigas, Natalia, Rosa, José Luis, Ventura, Francesc

“…Abstract Bone-specific transcription factors promote differentiation of mesenchymal precursors toward the osteoblastic cell phenotype. Among them, Runx2 and…”
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BMP-2 Induces Osterix Expression through Up-regulation of Dlx5 and Its Phosphorylation by p38 by Ulsamer, Arnau, Ortuño, Ma. José, Ruiz, Silvia, Susperregui, Antonio R.G., Osses, Nelson, Rosa, José Luis, Ventura, Francesc

“…Osterix, a zinc-finger transcription factor, is specifically expressed in osteoblasts and osteocytes of all developing bones. Because no bone formation occurs…”
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The p38α MAPK function in osteoprecursors is required for bone formation and bone homeostasis in adult mice by Rodríguez-Carballo, Edgardo, Gámez, Beatriz, Sedó-Cabezón, Lara, Sánchez-Feutrie, Manuela, Zorzano, Antonio, Manzanares-Céspedes, Cristina, Rosa, José Luis, Ventura, Francesc

“…p38 MAPK activity plays an important role in several steps of the osteoblast lineage progression through activation of osteoblast-specific transcription…”
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The p38/MK2/Hsp25 pathway is required for BMP-2-induced cell migration by Gamell, Cristina, Susperregui, Antonio G, Bernard, Ora, Rosa, José Luis, Ventura, Francesc

“…Bone morphogenetic proteins (BMPs) have been shown to participate in the patterning and specification of several tissues and organs during development and to…”
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Contribution of S6K1/MAPK signaling pathways in the response to oxidative stress: activation of RSK and MSK by hydrogen peroxide by Siebel, Anna, Cubillos-Rojas, Monica, Santos, Roberto Christ, Schneider, Taiane, Bonan, Carla Denise, Bartrons, Ramon, Ventura, Francesc, Rodrigues de Oliveira, Jarbas, Rosa, Jose Luis

“…Cells respond to different kind of stress through the coordinated activation of signaling pathways such as MAPK or p53. To find which molecular mechanisms are…”
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Glucose Restriction Promotes Osteocyte Specification by Activating a PGC-1α-Dependent Transcriptional Program by Sánchez-de-Diego, Cristina, Artigas, Natalia, Pimenta-Lopes, Carolina, Valer, José Antonio, Torrejon, Benjamin, Gama-Pérez, Pau, Villena, Josep A., Garcia-Roves, Pablo M., Rosa, José Luis, Ventura, Francesc

“…Osteocytes, the most abundant of bone cells, differentiate while they remain buried within the bone matrix. This encasement limits their access to nutrients…”
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Progressive Purkinje cell degeneration in tambaleante mutant mice is a consequence of a missense mutation in HERC1 E3 ubiquitin ligase by Mashimo, Tomoji, Hadjebi, Ouadah, Amair-Pinedo, Fabiola, Tsurumi, Toshiko, Langa, Francina, Serikawa, Tadao, Sotelo, Constantino, Guénet, Jean-Louis, Rosa, Jose Luis

“…The HERC gene family encodes proteins with two characteristic domains: HECT and RCC1-like. Proteins with HECT domains have been described to function as…”
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HERC 1 Ubiquitin Ligase Mutation Affects Neocortical, CA3 Hippocampal and Spinal Cord Projection Neurons: An Ultrastructural Study by Ruiz, Rocío, Pérez-Villegas, Eva María, Bachiller, Sara, Rosa, José Luis, Armengol, José Angel

“…The spontaneous mutation tambaleante is caused by the Gly483Glu substitution in the highly conserved N terminal RCC1-like domain of the HERC1 protein, which…”
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