Search Results - "Roques, Julie"

Basal‐like and classical cells coexist in pancreatic cancer revealed by single‐cell analysis on biopsy‐derived pancreatic cancer organoids from the classical subtype by Juiz, Natalia, Elkaoutari, Abdessamad, Bigonnet, Martin, Gayet, Odile, Roques, Julie, Nicolle, Rémy, Iovanna, Juan, Dusetti, Nelson

“…Pancreatic ductal adenocarcinoma (PDAC) is composed of stromal, immune, and cancerous epithelial cells. Transcriptomic analysis of the epithelial compartment…”
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Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions by Olivares, Orianne, Mayers, Jared R., Gouirand, Victoire, Torrence, Margaret E., Gicquel, Tristan, Borge, Laurence, Lac, Sophie, Roques, Julie, Lavaut, Marie-Noëlle, Berthezène, Patrice, Rubis, Marion, Secq, Veronique, Garcia, Stéphane, Moutardier, Vincent, Lombardo, Dominique, Iovanna, Juan Lucio, Tomasini, Richard, Guillaumond, Fabienne, Vander Heiden, Matthew G., Vasseur, Sophie

“…Tissue architecture contributes to pancreatic ductal adenocarcinoma (PDAC) phenotypes. Cancer cells within PDAC form gland-like structures embedded in a…”
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Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma by Guillaumond, Fabienne, Bidaut, Ghislain, Ouaissi, Mehdi, Servais, Stéphane, Gouirand, Victoire, Olivares, Orianne, Lac, Sophie, Borge, Laurence, Roques, Julie, Gayet, Odile, Pinault, Michelle, Guimaraes, Cyrille, Nigri, Jérémy, Loncle, Céline, Lavaut, Marie-Noëlle, Garcia, Stéphane, Tailleux, Anne, Staels, Bart, Calvo, Ezequiel, Tomasini, Richard, Iovanna, Juan Lucio, Vasseur, Sophie

“…The malignant progression of pancreatic ductal adenocarcinoma (PDAC) is accompanied by a profound desmoplasia, which forces proliferating tumor cells to…”
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Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness by Leca, Julie, Martinez, Sébastien, Lac, Sophie, Nigri, Jérémy, Secq, Véronique, Rubis, Marion, Bressy, Christian, Sergé, Arnauld, Lavaut, Marie-Noelle, Dusetti, Nelson, Loncle, Céline, Roques, Julie, Pietrasz, Daniel, Bousquet, Corinne, Garcia, Stéphane, Granjeaud, Samuel, Ouaissi, Mehdi, Bachet, Jean Baptiste, Brun, Christine, Iovanna, Juan L, Zimmermann, Pascale, Vasseur, Sophie, Tomasini, Richard

“…The intratumoral microenvironment, or stroma, is of major importance in the pathobiology of pancreatic ductal adenocarcinoma (PDA), and specific conditions in…”
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Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts by Nicolle, Rémy, Blum, Yuna, Marisa, Laetitia, Loncle, Celine, Gayet, Odile, Moutardier, Vincent, Turrini, Olivier, Giovannini, Marc, Bian, Benjamin, Bigonnet, Martin, Rubis, Marion, Elarouci, Nabila, Armenoult, Lucile, Ayadi, Mira, Duconseil, Pauline, Gasmi, Mohamed, Ouaissi, Mehdi, Maignan, Aurélie, Lomberk, Gwen, Boher, Jean-Marie, Ewald, Jacques, Bories, Erwan, Garnier, Jonathan, Goncalves, Anthony, Poizat, Flora, Raoul, Jean-Luc, Secq, Veronique, Garcia, Stephane, Grandval, Philippe, Barraud-Blanc, Marine, Norguet, Emmanuelle, Gilabert, Marine, Delpero, Jean-Robert, Roques, Julie, Calvo, Ezequiel, Guillaumond, Fabienne, Vasseur, Sophie, Urrutia, Raul, de Reyniès, Aurélien, Dusetti, Nelson, Iovanna, Juan

“…Preclinical models based on patient-derived xenografts have remarkable specificity in distinguishing transformed human tumor cells from non-transformed murine…”
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TNF-α induces endothelial–mesenchymal transition promoting stromal development of pancreatic adenocarcinoma by Adjuto-Saccone, Marjorie, Soubeyran, Philippe, Garcia, Julie, Audebert, Stéphane, Camoin, Luc, Rubis, Marion, Roques, Julie, Binétruy, Bernard, Iovanna, Juan Lucio, Tournaire, Roselyne

“…Endothelial–mesenchymal transition (EndMT) is an important source of cancer-associated fibroblasts (CAFs), which facilitates tumour progression. PDAC is…”
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Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer by Nicolle, Rémy, Blum, Yuna, Duconseil, Pauline, Vanbrugghe, Charles, Brandone, Nicolas, Poizat, Flora, Roques, Julie, Bigonnet, Martin, Gayet, Odile, Rubis, Marion, Elarouci, Nabila, Armenoult, Lucile, Ayadi, Mira, de Reyniès, Aurélien, Giovannini, Marc, Grandval, Philippe, Garcia, Stephane, Canivet, Cindy, Cros, Jérôme, Bournet, Barbara, Buscail, Louis, Moutardier, Vincent, Gilabert, Marine, Iovanna, Juan, Dusetti, Nelson

“…A significant gap in pancreatic ductal adenocarcinoma (PDAC) patient's care is the lack of molecular parameters characterizing tumours and allowing a…”
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A glycosyltransferase gene signature to detect pancreatic ductal adenocarcinoma patients with poor prognosis by Mohamed Abd-El-Halim, Yousra, El Kaoutari, Abdessamad, Silvy, Françoise, Rubis, Marion, Bigonnet, Martin, Roques, Julie, Cros, Jérôme, Nicolle, Rémy, Iovanna, Juan, Dusetti, Nelson, Mas, Eric

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by an important heterogeneity, reflected by different clinical outcomes and chemoresistance. During…”
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Pancreatic Cancer Organoids for Determining Sensitivity to Bromodomain and Extra-Terminal Inhibitors (BETi) by Bian, Benjamin, Juiz, Natalia Anahi, Gayet, Odile, Bigonnet, Martin, Brandone, Nicolas, Roques, Julie, Cros, Jérôme, Wang, Nenghui, Dusetti, Nelson, Iovanna, Juan

“…Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease, therefore stratification of patients is essential to predict their responses to therapies…”
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Metabolomic profiling of pancreatic adenocarcinoma reveals key features driving clinical outcome and drug resistance by Kaoutari, Abdessamad El, Fraunhoffer, Nicolas A., Hoare, Owen, Teyssedou, Carlos, Soubeyran, Philippe, Gayet, Odile, Roques, Julie, Lomberk, Gwen, Urrutia, Raul, Dusetti, Nelson, Iovanna, Juan

“…Although significant advances have been made recently to characterize the biology of pancreatic ductal adenocarcinoma (PDAC), more efforts are needed to…”
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Multi-omics data integration and modeling unravels new mechanisms for pancreatic cancer and improves prognostic prediction by Fraunhoffer, Nicolas A., Abuelafia, Analía Meilerman, Bigonnet, Martin, Gayet, Odile, Roques, Julie, Nicolle, Remy, Lomberk, Gwen, Urrutia, Raul, Dusetti, Nelson, Iovanna, Juan

“…Pancreatic ductal adenocarcinoma (PDAC), has recently been found to be a heterogeneous disease, although the extension of its diversity remains to be fully…”
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Inhibition of glucuronidation in pancreatic cancer improves gemcitabine anticancer activity by Fraunhoffer, Nicolas Alejandro, Abuelafia, Analía Meilerman, Chanez, Brice, Bigonnet, Martin, Gayet, Odile, Roques, Julie, Chuluyan, Eduardo, Dusetti, Nelson, Iovanna, Juan

“…Abbreviations Ac Agglomerative coefficient CCL ommercial cell lines CI Confidence interval DFS Disease-free survival FDR False discovery rate HR Hazard ratio…”
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LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker by Bressy, Christian, Lac, Sophie, Nigri, Jérémy, Leca, Julie, Roques, Julie, Lavaut, Marie-Nöelle, Secq, Véronique, Guillaumond, Fabienne, Bui, Thi-Thien, Pietrasz, Daniel, Granjeaud, Samuel, Bachet, Jean-Baptiste, Ouaissi, Mehdi, Iovanna, Juan, Vasseur, Sophie, Tomasini, Richard

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive stroma and pathogenic modifications to the peripheral nervous system that elevate…”
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Evidencing a Pancreatic Ductal Adenocarcinoma Subpopulation Sensitive to the Proteasome Inhibitor Carfilzomib by Fraunhoffer, Nicolas A, Abuelafia, Analía Meilerman, Bigonnet, Martin, Gayet, Odile, Roques, Julie, Telle, Emmanuel, Santofimia-Castaño, Patricia, Borrello, María Teresa, Chuluyan, Eduardo, Dusetti, Nelson, Iovanna, Juan

“…Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a survival rate less than 5%. Multiple chemotherapeutic drugs have been tested to improve…”
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Secretory leukocyte proteinase inhibitor: A key player in the dialogue between the tumor and its microenvironment in pancreatic cancer patients by Chuluyan, Eduardo, Ambrosi, Nella, Fraunhoffer, Nicolas, Caro, Fiorella, Remolins, Carla, Reiteri, Macarena, Guerrieri, Diego, Soubeyran, Philippe, Gayet, Odile, Roques, Julie, Nelson, Dusetti J., Incardona, Claudio A., Iovanna, Juan

“…Abstract only 592 Background: Secretory leukocyte proteinase inhibitor (SLPI) is a non-glycosylated pleiotropic protein with anti-protease, microbicidal,…”
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PML hyposumoylation is responsible for the resistance of pancreatic cancer by Swayden, Mirna, Alzeeb, George, Masoud, Rawand, Berthois, Yolande, Audebert, Stéphane, Camoin, Luc, Hannouche, Laurent, Vachon, Hortense, Gayet, Odile, Bigonnet, Martin, Roques, Julie, Silvy, Françoise, Carrier, Alice, Dusetti, Nelson, Iovanna, Juan L., Soubeyran, Philippe

“…The dismal prognosis of pancreatic ductal adenocarcinoma (PDAC) is mainly due to its rapidly acquired resistance to all conventional treatments. Despite…”
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TNF-α induces endothelial–mesenchymal transition promoting stromal development of pancreatic adenocarcinoma by Adjuto-Saccone, Marjorie, Soubeyran, Philippe, Garcia, Julie, Audebert, Stéphane, Camoin, Luc, Rubis, Marion, Roques, Julie, Binétruy, Bernard, Iovanna, Juan Lucio, Tournaire, Roselyne Binetruy

“…Abstract Endothelial–mesenchymal transition (EndMT) is an important source of cancer-associated fibroblasts (CAFs), which facilitates tumour progression. PDAC…”
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PAP/REG3A favors perineural invasion in pancreatic adenocarcinoma and serves as a prognostic marker by Nigri, Jérémy, Gironella, Meritxell, Bressy, Christian, Vila-Navarro, Elena, Roques, Julie, Lac, Sophie, Bontemps, Caroline, Kozaczyk, Coraline, Cros, Jérôme, Pietrasz, Daniel, Maréchal, Raphaël, Van Laethem, Jean-Luc, Iovanna, Juan, Bachet, Jean-Baptiste, Folch-Puy, Emma, Tomasini, Richard

“…Pancreatic ductal adenocarcinoma (PDA) is a fatal and insidious malignant disease for which clinicians’ tools are restricted by the current limits in knowledge…”
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Endothelial-Mesenchymal-Transition induced by TNF-α: Implication in cancer-associated fibroblasts (CAFs) formation in pancreatic cancer by Saccone, Marjorie Adjuto, Garcia, Julie, Roques, Julie, Soubeyran, Philippe, Iovanna, Juan-Lucio, Tournaire, Roselyne

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Pancreatic ductal adenocarcinoma ubiquitination profiling reveals specific prognostic and theranostic markers by El Kaoutari, Abdessamad, Fraunhoffer, Nicolas A., Audebert, Stéphane, Camoin, Luc, Berthois, Yolande, Gayet, Odile, Roques, Julie, Bigonnet, Martin, Bongrain, Claire, Ciccolini, Joseph, Iovanna, Juan L., Dusetti, Nelson J., Soubeyran, Philippe

“…Pancreatic ductal adenocarcinoma (PDAC) has been widely studied at multiomics level. However, little is known about its specific ubiquitination, a major…”
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