Search Results - "Roques, B. P"

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene by Matthes, Hans W. D, Maldonado, Rafael, Simonin, Frédéric, Valverde, Olga, Slowe, Susan, Kitchen, Ian, Befort, Katia, Dierich, Andrée, Le Meur, Marianne, Dollé, Pascal, Tzavara, Eleni, Hanoune, Jacques, Roques, Bernard P, Kieffer, Brigitte L

“…Despite tremendous efforts in the search for safe, efficacious and non-addictive opioids for pain treatment, morphine remains the most valuable painkiller in…”
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Physiological control of emotion-related behaviors by endogenous enkephalins involves essentially the delta opioid receptors by Nieto, M. Mas, Guen, S.L.E., Kieffer, B.L., Roques, B.P., Noble, F.

“…The endogenous pentapeptide enkephalins bind to the mu and delta opioid receptors, with a slightly higher affinity for the latter. It remains a controversy…”
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Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice by LEDENT, C, VALVERDE, O, VASSART, G, FRATTA, W, PARMENTIER, M, COSSU, G, PETITET, F, AUBERT, J.-F, BESLOT, F, BÖHME, G. A, IMPERATO, A, PEDRAZZINI, T, ROQUES, B. P

“…The function of the central cannabinoid receptor (CB1) was investigated by invalidating its gene. Mutant mice did not respond to cannabinoid drugs,…”
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Nucleic Acid Sequence Discrimination by the HIV-1 Nucleocapsid Protein NCp7:  A Fluorescence Study by Vuilleumier, C, Bombarda, E, Morellet, N, Gérard, D, Roques, B. P, Mély, Y

“…The critical functions of the HIV-1 nucleocapsid protein NCp7 in genomic RNA packaging and reverse transcription, essentially rely on interactions with nucleic…”
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NMR Structure of the HIV-1 Regulatory Protein VPR by Morellet, N, Bouaziz, S, Petitjean, P, Roques, B.P

“…The human immunodeficiency virus type 1 (HIV-1) genome encodes a highly conserved regulatory gene product, Vpr (96 residues, 14 kDa), which is incorporated…”
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Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding by Gajiwala, Ketan S, Chen, Hua, Cornille, Fabrice, Roques, Bernard P, Reith, Walter, Mach, Bernard, Burley, Stephen K

“…Regulatory factor X (RFX) proteins are transcriptional activators that recognize X-boxes (DNA of the sequence 5′-GTNRCC(0-3N)RGYAAC-3′, where N is any…”
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Absence of opiate rewarding effects in mice lacking dopamine D2 receptors by Borrelli, Emiliana, Maldonado, Rafael, Saiardi, Adolfo, Valverde, Olga, Samad, Tarek A, Roques, Bernard P

“…Dopamine receptors have been implicated in the behavioural response to drugs of abuse. These responses are mediated particularly by the mesolimbic dopaminergic…”
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Activity of the delta -Opioid Receptor Is Partially Reduced, Whereas Activity of the kappa -Receptor Is Maintained in Mice Lacking the µ-Receptor by Matthes, H. W. D, Smadja, C, Valverde, O, Vonesch, J.-L, Foutz, A. S, Boudinot, E, Denavit-Saubie, M, Severini, C, Negri, L, Roques, B. P, Maldonado, R, Kieffer, B. L

“…Previous pharmacological studies have indicated the possible existence of functional interactions between mu-, delta- and kappa-opioid receptors in the CNS. We…”
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Blockade of morphine‐induced behavioral sensitization by a combination of amisulpride and RB101, comparison with classical opioid maintenance treatments by Cordonnier, L, Sanchez, M, Roques, B P, Noble, F

“…Background and purpose: Maintenance treatments with methadone or buprenorphine are more or less efficient procedures for helping heroin addicts to stop or…”
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Specific blockade of morphine- and cocaine-induced reinforcing effects in conditioned place preference by nitrous oxide in mice by Benturquia, N, Le Guen, S, Canestrelli, C, Lagente, V, Apiou, G, Roques, B.P, Noble, F

“…Abstract Nitrous oxide (N2 O), a pharmacological active gas and an antagonist of N-methyl-D-aspartic acid receptors, has been reported to be effective in the…”
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Molecular mimicry in inducing DNA damage between HIV-1 Vpr and the anticancer agent, cisplatin by Siddiqui, K, Del Valle, L, Morellet, N, Cui, J, Ghafouri, M, Mukerjee, R, Urbanska, K, Fan, S, Pattillo, C B, Deshmane, S L, Kiani, M F, Ansari, R, Khalili, K, Roques, B P, Reiss, K, Bouaziz, S, Amini, S, Srinivasan, A, Sawaya, B E

“…The human immunodeficiency virus type 1 (HIV-1) viral protein R ( vpr ) gene is an evolutionarily conserved gene among the primate lentiviruses. Several…”
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Facilitation of enkephalins-induced delta-opioid behavioral responses by chronic amisulpride treatment by Cordonnier, L., Sanchez, M., Roques, B.P., Noble, F.

“…The endogenous opioid system is known to have a great influence on the dopaminergic system. Conversely, blockade of the dopaminergic system in D2 receptor…”
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Target Specificity of Human Immunodeficiency Virus Type 1 NCp7 Requires an Intact Conformation of Its CCHC N-Terminal Zinc Finger by RAMBOARINA, S, DRUILLENNEC, S, MORELLET, N, BOUAZIZ, S, ROQUES, B. P

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Identification of Metabolic Pathways of Brain Angiotensin II and III Using Specific Aminopeptidase Inhibitors: Predominant Role of Angiotensin III in the Control of Vasopressin Release by Zini, Sylvie, Fournie-Zaluski, Marie-Claude, Chauvel, Eric, Roques, Bernard P., Corvol, Pierre, Llorens-Cortes, Catherine

“…Angiotensin (Ang) II and Ang III are two peptide effectors of the brain renin-angiotensin system that participate in the control of blood pressure and increase…”
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Reduction of Morphine Abstinence in Mice with a Mutation in the Gene Encoding CREB by Maldonado, Rafael, Blendy, Julie A., Tzavara, Eleni, Gass, Peter, Roques, Bernard P., Hanoune, Jacques, Schütz, Günter

“…Chronic morphine administration induces an up-regulation of several components of the cyclic adenosine 5′-monophosphate (cAMP) signal transduction cascade. The…”
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Phosphinic Derivatives as New Dual Enkephalin-Degrading Enzyme Inhibitors: Synthesis, Biological Properties, and Antinociceptive Activities by Chen, Huixiong, Noble, Florence, Mothé, Aurélie, Meudal, Hervé, Coric, Pascale, Danascimento, Sophie, Roques, Bernard P, George, Pascal, Fournié-Zaluski, Marie-Claude

“…The development of dual inhibitors of the two zinc metallopeptidases, neprilysin (neutral endopeptidase) and aminopeptidase N involved in the inactivation of…”
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Zinc Binding to the HIV-1 Nucleocapsid Protein:  A Thermodynamic Investigation by Fluorescence Spectroscopy by Mély, Y, De Rocquigny, H, Morellet, N, Roques, B. P, Gérard, D

“…The HIV-1 nucleocapsid protein, NCp7, is characterized by two CCHC zinc finger motifs which have been shown to stoichiometrically bind zinc in mature virions…”
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Behavioural and biochemical evidence for signs of abstinence in mice chronically treated with Δ‐9‐tetrahydrocannabinol by Hutcheson, Daniel M, Tzavara, Eleni Th, Smadja, Claire, Valjent, Emmanuel, Roques, Bernard P, Hanoune, Jacques, Maldonado, Rafael

“…Tolerance and dependence induced by chronic Δ‐9‐tetrahydrocannabinol (THC) administration were investigated in mice. The effects on body weight, analgesia and…”
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Acute effect of the dual angiotensin‐converting enzyme and neutral endopeptidase 24‐11 inhibitor mixanpril on insulin sensitivity in obese Zucker rat by Arbin, V, Claperon, N, Fournié‐Zaluski, M ‐C, Roques, B P, Peyroux, J

“…The aim of this study was to determine whether acute dual angiotensin‐converting enzyme (ACE)/neutral endopeptidase 24‐11 (NEP) inhibition could improve whole…”
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Zn2+ Binding Properties of Single-Point Mutants of the C-Terminal Zinc Finger of the HIV-1 Nucleocapsid Protein:  Evidence of a Critical Role of Cysteine 49 in Zn2+ Dissociation by Bombarda, E, Cherradi, H, Morellet, N, Roques, B. P, Mély, Y

“…The two highly conserved Zn2+ finger motifs of the HIV-1 nucleocapsid protein, NCp7, strongly bind Zn2+ through coordination of one His and three Cys residues…”
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