Evaluation of Left Ventricular Diastolic Function by Echocardiography with Tissue Doppler in Systemic Sclerosis

Systemic sclerosis (SS) is a connective tissue abnormality characterized by fibrosis of the skin and internal organs. Cardiac involvement with consequent myocardial dysfunction in SS is associated with increased morbidity and mortality. To investigate the left ventricular (LV) diastolic function in...

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Published in:	Arquivos brasileiros de cardiologia Vol. 109; no. 5; pp. 410 - 415
Main Authors:	Roque, Marina Carneiro de Freitas, Sampaio-Barros, Percival D, Arruda, Ana Lucia, Barros-Gomes, Sergio, Becker, Derly, Andrade, José Lazaro de, Rodrigues, Ana Clara Tude
Format:	Journal Article
Language:	English
Published:	Brazil Sociedade Brasileira de Cardiologia - SBC 01-11-2017 Sociedade Brasileira de Cardiologia (SBC)
Subjects:	CARDIAC & CARDIOVASCULAR SYSTEMS Disfunção Ventricular Esquerda Ecocardiografia Doppler Escleroderma Sistêmico Original Ventrículos do Coração / função Ecocardiografia Doppler Ventricular Dysfunction, Left Heart Ventricles / function Escleroderma Sistêmico Disfunção Ventricular Esquerda Echocardiography, Doppler Ventrículos do Coração / função Sleroderma, Systemic
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Summary:	Systemic sclerosis (SS) is a connective tissue abnormality characterized by fibrosis of the skin and internal organs. Cardiac involvement with consequent myocardial dysfunction in SS is associated with increased morbidity and mortality. To investigate the left ventricular (LV) diastolic function in patients with SS and preserved systolic function. Patients with SS were evaluated with two-dimensional echocardiography with tissue Doppler for analysis of chamber diameters, LV mass index (LVMI), indexed left atrial volume (iLAV), systolic function of both ventricles, and presence and degree of diastolic dysfunction (DD). We evaluated 50 patients, divided according to the presence of DD into Group 1 (n = 25; normal diastolic function, E/A ratio ≥ 0.8, deceleration time [DT] > 150 ms and < 200 ms, and septal e' > 8 cm/s) and Group 2 (n = 25; with DD, subdivided into type I DD [E/A < 0.8, DT > 200 ms], type II [E/A ≥ 0.8, septal e' < 8 cm/s, iLAV > 34 mL/m2], and type III [E/A > 2, DT < 150 ms, septal e' < 8 cm/s]). Type I DD was the most frequent (34%), followed by type II DD (16%). LVMI and iLAV were similar in both groups, but septal and lateral e' were reduced only in Group 2. In Group 2, we observed that patients with moderate DD had longer disease duration (p = 0.02). The prevalence of type I DD was elevated in SS and associated with aging. Disease duration emerged as an important factor in moderate DD.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0066-782X 1678-4170 1678-4170
DOI:	10.5935/abc.20170145