Search Results - "Roque, Jonasel"
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A single-cell atlas of the peripheral immune response in patients with severe COVID-19
Published in Nature medicine (01-07-2020)“…There is an urgent need to better understand the pathophysiology of Coronavirus disease 2019 (COVID-19), the global pandemic caused by SARS-CoV-2, which has…”
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A generalizable 29-mRNA neural-network classifier for acute bacterial and viral infections
Published in Nature communications (04-03-2020)“…Improved identification of bacterial and viral infections would reduce morbidity from sepsis, reduce antibiotic overuse, and lower healthcare costs. Here, we…”
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Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis
Published in JCI insight (03-09-2020)“…BACKGROUNDElevated levels of inflammatory cytokines have been associated with poor outcomes among COVID-19 patients. It is unknown, however, how these levels…”
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Prospective validation of an 11-gene mRNA host response score for mortality risk stratification in the intensive care unit
Published in Scientific reports (22-06-2021)“…Several clinical calculators predict intensive care unit (ICU) mortality, however these are cumbersome and often require 24 h of data to calculate…”
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Deconvoluting complex correlates of COVID-19 severity with a multi-omic pandemic tracking strategy
Published in Nature communications (30-08-2022)“…The SARS-CoV-2 pandemic has differentially impacted populations across race and ethnicity. A multi-omic approach represents a powerful tool to examine risk…”
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Autoantibodies are highly prevalent in non-SARS-CoV-2 respiratory infections and critical illness
Published in JCI insight (08-02-2023)“…The widespread presence of autoantibodies in acute infection with SARS-CoV-2 is increasingly recognized, but the prevalence of autoantibodies in non-SARS-CoV-2…”
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Association between emergency department disposition and mortality in patients with COVID‐19 acute respiratory distress syndrome
Published in Journal of the American College of Emergency Physicians Open (01-06-2024)“…Objectives Patients hospitalized for COVID‐19 frequently develop hypoxemia and acute respiratory distress syndrome (ARDS) after admission. In non‐COVID‐19 ARDS…”
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Effectiveness of Monovalent mRNA Vaccines Against COVID-19-Associated Hospitalization Among Immunocompetent Adults During BA.1/BA.2 and BA.4/BA.5 Predominant Periods of SARS-CoV-2 Omicron Variant in the United States - IVY Network, 18 States, December 26, 2021-August 31, 2022
Published in MMWR. Morbidity and mortality weekly report (21-10-2022)“…The SARS-CoV-2 Omicron variant (B.1.1.529 or BA.1) became predominant in the United States by late December 2021 (1). BA.1 has since been replaced by emerging…”
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Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial
Published in JAMA : the journal of the American Medical Association (01-12-2020)“…IMPORTANCE: Data on the efficacy of hydroxychloroquine for the treatment of coronavirus disease 2019 (COVID-19) are needed. OBJECTIVE: To determine whether…”
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Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trial
Published in The Lancet infectious diseases (01-05-2022)“…We aimed to assess the efficacy and safety of two neutralising monoclonal antibody therapies (sotrovimab [Vir Biotechnology and GlaxoSmithKline] and BRII-196…”
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Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19
Published in The Journal of experimental medicine (02-08-2021)“…Our understanding of protective versus pathological immune responses to SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), is limited by…”
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Vaccine effectiveness of primary series and booster doses against covid-19 associated hospital admissions in the United States: living test negative design study
Published in BMJ (Online) (11-10-2022)“…To compare the effectiveness of a primary covid-19 vaccine series plus booster doses with a primary series alone for the prevention of hospital admission with…”
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SARS-CoV-2 RNAemia Predicts Clinical Deterioration and Extrapulmonary Complications from COVID-19
Published in Clinical infectious diseases (29-01-2022)“…Abstract Background The determinants of coronavirus disease 2019 (COVID-19) disease severity and extrapulmonary complications (EPCs) are poorly understood. We…”
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Comparative Effectiveness of Moderna, Pfizer-BioNTech, and Janssen (Johnson & Johnson) Vaccines in Preventing COVID-19 Hospitalizations Among Adults Without Immunocompromising Conditions - United States, March-August 2021
Published in MMWR. Morbidity and mortality weekly report (24-09-2021)“…Three COVID-19 vaccines are authorized or approved for use among adults in the United States (1,2). Two 2-dose mRNA vaccines, mRNA-1273 from Moderna and…”
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Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study
Published in Nature communications (03-01-2024)“…Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively…”
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Effectiveness of mRNA Vaccines Against COVID-19 Hospitalization by Age and Chronic Medical Conditions Burden Among Immunocompetent US Adults, March-August 2021
Published in The Journal of infectious diseases (16-05-2022)“…Abstract Vaccine effectiveness (VE) against COVID-19 hospitalization was evaluated among immunocompetent adults (≥18 years) during March–August 2021 using a…”
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Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against COVID-19 Among Hospitalized Adults Aged ≥65 Years - United States, January-March 2021
Published in MMWR. Morbidity and mortality weekly report (07-05-2021)“…Adults aged ≥65 years are at increased risk for severe outcomes from COVID-19 and were identified as a priority group to receive the first COVID-19 vaccines…”
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IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition
Published in Nature communications (09-01-2024)“…The glycosylation of IgG plays a critical role during human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, activating immune cells and…”
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Organization of Outpatient Care After COVID-19 Hospitalization
Published in Chest (01-06-2022)Get full text
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Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study
Published in EBioMedicine (01-09-2022)“…Better understanding of the association between characteristics of patients hospitalized with coronavirus disease 2019 (COVID-19) and outcome is needed to…”
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