Search Results - "Roque, Cássia R."

Immunoinflammatory role of apolipoprotein E4 in malnutrition and enteric infections and the increased risk for chronic diseases under adverse environments by Freitas, Raul S, Roque, Cássia R, Matos, Gabriella A, Belayev, Ludmila, de Azevedo, Orleâncio G R, Alvarez-Leite, Jacqueline I, Guerrant, Richard L, Oriá, Reinaldo B

“…Abstract Apolipoprotein E plays a crucial role in cholesterol metabolism. The immunomodulatory functions of the human polymorphic APOE gene have gained…”
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Myeloperoxidase as a biomarker for intestinal-brain axis dysfunction induced by malnutrition and Cryptosporidium infection in weanling mice by Oriá, Reinaldo B., Costa, Deiziane V.S., de Medeiros, Pedro Henrique Q.S., Roque, Cássia R., Dias, Ronaldo P., Warren, Cirle A., Bolick, David T., Guerrant, Richard L.

“…Cryptosporidiosis is a waterborne protozoal infection that may cause life-threatening diarrhea in undernourished children living in unsanitary environments…”
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Chronic Methylmercury Intoxication Induces Systemic Inflammation, Behavioral, and Hippocampal Amino Acid Changes in C57BL6J Adult Mice by Nascimento, Tyciane S, Pinto, Daniel V, Dias, Ronaldo P, Raposo, Ramon S, Nunes, Paulo Iury G, Roque, Cássia R, Santos, Flávia A, Andrade, Geanne M, Viana, José Lucas, Fostier, Anne H, Sussulini, Alessandra, Alvarez-Leite, Jacqueline I, Fontes-Ribeiro, Carlos, Malva, João O, Oriá, Reinaldo B

“…Methylmercury (MeHg) is highly toxic to the human brain. Although much is known about MeHg neurotoxic effects, less is known about how chronic MeHg affects…”
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Methylmercury chronic exposure affects the expression of DNA single-strand break repair genes, induces oxidative stress, and chromosomal abnormalities in young dyslipidemic APOE knockout mice by Roque, Cássia R., Sampaio, Letícia R., Ito, Mayumi N., Pinto, Daniel V., Caminha, Juan S.R., Nunes, Paulo I.G., Raposo, Ramon S., Santos, Flávia A., Windmöller, Cláudia C., Crespo-Lopez, Maria Elena, Alvarez-Leite, Jacqueline I., Oriá, Reinaldo B., Pinheiro, Ronald F.

“…Mercury (Hg) is one of the most toxic environmental pollutants, especially when methylated, forming methylmercury (MeHg). MeHg affects DNA repair, increases…”
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ApoE Mimetic Peptides to Improve the Vicious Cycle of Malnutrition and Enteric Infections by Targeting the Intestinal and Blood-Brain Barriers by Oriá, Reinaldo B, Freitas, Raul S, Roque, Cássia R, Nascimento, José Carlos R, Silva, Ana Paula, Malva, João O, Guerrant, Richard L, Vitek, Michael P

“…Apolipoprotein E (apoE) mimetic peptides are engineered fragments of the native apoE protein's LDL-receptor binding site that improve the outcomes following a…”
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Inhibitory effects of a standardized extract of Justicia pectoralis in an experimental rat model of airway hyper‐responsiveness by Moura, Carlos T. M., Batista‐Lima, Francisco J., Brito, Teresinha S., Silva, Alfredo A. V., Ferreira, Luan C., Roque, Cássia R., Aragão, Karoline S., Havt, Alexandre, Fonseca, Francisco N., Leal, Luzia K. A. M., Magalhães, Pedro J. C.

“…Objective Justicia pectoralis is a plant useful for the treatment of respiratory diseases. Here, we studied the antiasthmatic properties of a standardized…”
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Blocking pro-inflammatory platelet-activating factor receptors and activating cell survival pathways: A novel therapeutic strategy in experimental ischemic stroke by Belayev, Ludmila, Obenaus, Andre, Mukherjee, Pranab K, Knott, Eric J, Khoutorova, Larissa, Reid, Madigan M, Roque, Cassia R, Nguyen, Lawrence, Lee, Jeong Bin, Petasis, Nicos A, Oria, Reinaldo B, Bazan, Nicolas G

“…Acute ischemic stroke triggers complex neurovascular, neuroinflammatory, and synaptic alterations. This study explores whether blocking pro-inflammatory…”
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NPD1 Plus RvD1 Mediated Ischemic Stroke Penumbra Protection Increases Expression of Pro-homeostatic Microglial and Astrocyte Genes by Reid, Madigan M., Kautzmann, Marie-Audrey I., Andrew, Gethein, Obenaus, Andre, Mukherjee, Pranab K., Khoutorova, Larissa, Ji, Jeff X., Roque, Cassia R., Oria, Reinaldo B., Habeb, Bola F., Belayev, Ludmila, Bazan, Nicolas G.

“…Neuroprotection to attenuate or block the ischemic cascade and salvage neuronal damage has been extensively explored for treating ischemic stroke. However,…”
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Synergistic neuroprotection by a PAF antagonist plus a docosanoid in experimental ischemic stroke: Dose-response and therapeutic window by Reid, Madigan M., Obenaus, Andre, Mukherjee, Pranab K., Khoutorova, Larissa, Roque, Cassia R., Petasis, Nicos A., Oria, Reinaldo B., Belayev, Ludmila, Bazan, Nicolas G.

“…We tested the hypothesis that blocking pro-inflammatory platelet-activating factor receptor (PAFR) with LAU-0901 (LAU) plus administering a selected…”
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Abstract TP212: Robust Neuroprotection With PAF-R Antagonist Plus AT-NPD1 In Experimental Ischemic Stroke: Dose-response And Therapeutic Window by Belayev, Ludmila, Reid, Madigan, Obenaus, Andre, Mukherjee, Pranab, Khoutorova, Larissa, Oria, Reinaldo, Roque, Cassia R, Bazan, Nicolas G

“…ObjectiveWe examined the neuroprotective efficacy, including dose-responses and therapeutic window of 1) LAU-0901, receptor antagonist of the bioactive…”
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Abstract WP263: Effective Combination Therapy For Experimental Stroke: Synergistic Neuroprotection By Lau-0901 And At-npd1 by Belayev, Ludmila, Mukherjee, Pranab, Reid, Madigan, Obenaus, Andre, Khoutorova, Larissa, Roque, Cassia R, Simons, Tyler, Park, Bohyung Katie, Oria, Reinaldo, Bazan, Nicolas G

“…ObjectiveCerebral ischemia causes irreversible brain damage, which involves oxidative stress, the release of endogenous substances and inflammation. We tested…”
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Abstract WP235: Docosanoids Protect Inflammation-induced Brain Damage And Lead To Neurological Recovery In Experimental Stroke by Bazan, Nicolas G, Mukherjee, Pranab K, Reid, Madigan M, Obenaus, Andre, Khoutorova, Larissa, Roque, Cassia R, Desai, Neehar N, Simons, Tyler, Ji, Jeff, Oria, Reinaldo B, Belayev, Ludmila

“…ObjectiveCerebral ischemia initiates lipid peroxidation, uncompensated oxidative stress, and neuronal damage. We investigated the neuroprotective bioactivity…”
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