Search Results - "Roper, Jatin"

High-fructose corn syrup enhances intestinal tumor growth in mice by Goncalves, Marcus D, Lu, Changyuan, Tutnauer, Jordan, Hartman, Travis E, Hwang, Seo-Kyoung, Murphy, Charles J, Pauli, Chantal, Morris, Roxanne, Taylor, Sam, Bosch, Kaitlyn, Yang, Sukjin, Wang, Yumei, Van Riper, Justin, Lekaye, H Carl, Roper, Jatin, Kim, Young, Chen, Qiuying, Gross, Steven S, Rhee, Kyu Y, Cantley, Lewis C, Yun, Jihye

“…Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is associated with obesity and with an increased risk of colorectal cancer…”
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S3736 A Case of Exercise-Induced Colonic Ischemia in a Middle-Aged Female Athlete Responsive to Novel Therapeutic Approach of Sildenafil and Fludrocortisone by Gadi, Sanjay, Brandt, Lawrence J., Roper, Jatin

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S223 Radiation Induces BRCA1 Expression in a Genetically Engineered Mouse Model of Colorectal Cancer by Nabbout, Rafic, Lee, Chang-Lung, Roper, Jatin

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Gut organoids: mini-tissues in culture to study intestinal physiology and disease by Almeqdadi, Mohammad, Mana, Miyeko D, Roper, Jatin, Yilmaz, Ömer H

“…In vitro, cell cultures are essential tools in the study of intestinal function and disease. For the past few decades, monolayer cellular cultures, such as…”
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S374 Folate Receptor Is a Marker of Colorectal Adenoma in a Prospective Cohort of Matched Colorectal Adenoma and Normal Colon Organoids by Nabbout, Rafic, Dufault, Darin, Shi, Chanjuan, Boardman, Lisa, Sokolov, Igor, Roper, Jatin

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S1679 Association of Gut Microbiome With COVID-19 Status in Children in the BRAVE Cohort by Mohamed, Ghada, Jiang, Danting, Hurst, Jillian, Kelly, Matthew, Surana, Neeraj, Roper, Jatin

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Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis by Jackstadt, Rene, van Hooff, Sander R., Leach, Joshua D., Cortes-Lavaud, Xabier, Lohuis, Jeroen O., Ridgway, Rachel A., Wouters, Valérie M., Roper, Jatin, Kendall, Timothy J., Roxburgh, Campbell S., Horgan, Paul G., Nixon, Colin, Nourse, Craig, Gunzer, Matthias, Clark, William, Hedley, Ann, Yilmaz, Omer H., Rashid, Mamunur, Bailey, Peter, Biankin, Andrew V., Campbell, Andrew D., Adams, David J., Barry, Simon T., Steele, Colin W., Medema, Jan Paul, Sansom, Owen J.

“…The metastatic process of colorectal cancer (CRC) is not fully understood and effective therapies are lacking. We show that activation of NOTCH1 signaling in…”
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Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer by Cheung, Priscilla, Xiol, Jordi, Dill, Michael T., Yuan, Wei-Chien, Panero, Riccardo, Roper, Jatin, Osorio, Fernando G., Maglic, Dejan, Li, Qi, Gurung, Basanta, Calogero, Raffaele A., Yilmaz, Ömer H., Mao, Junhao, Camargo, Fernando D.

“…Although the Hippo transcriptional coactivator YAP is considered oncogenic in many tissues, its roles in intestinal homeostasis and colorectal cancer (CRC)…”
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WRN helicase is a synthetic lethal target in microsatellite unstable cancers by Chan, Edmond M., Shibue, Tsukasa, McFarland, James M., Gaeta, Benjamin, Ghandi, Mahmoud, Dumont, Nancy, Gonzalez, Alfredo, McPartlan, Justine S., Li, Tianxia, Zhang, Yanxi, Bin Liu, Jie, Lazaro, Jean-Bernard, Gu, Peili, Piett, Cortt G., Apffel, Annie, Ali, Syed O., Deasy, Rebecca, Keskula, Paula, Ng, Raymond W. S., Roberts, Emma A., Reznichenko, Elizaveta, Leung, Lisa, Alimova, Maria, Schenone, Monica, Islam, Mirazul, Maruvka, Yosef E., Liu, Yang, Roper, Jatin, Raghavan, Srivatsan, Giannakis, Marios, Tseng, Yuen-Yi, Nagel, Zachary D., D’Andrea, Alan, Root, David E., Boehm, Jesse S., Getz, Gad, Chang, Sandy, Golub, Todd R., Tsherniak, Aviad, Vazquez, Francisca, Bass, Adam J.

“…Synthetic lethality—an interaction between two genetic events through which the co-occurrence of these two genetic events leads to cell death, but each event…”
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Colonoscopy-based colorectal cancer modeling in mice with CRISPR–Cas9 genome editing and organoid transplantation by Roper, Jatin, Tammela, Tuomas, Akkad, Adam, Almeqdadi, Mohammad, Santos, Sebastian B, Jacks, Tyler, Yilmaz, Ömer H

“…Colonoscopy-guided mucosal injection is used to induce site-directed tumors and to transplant tumors into the distal colons of mice. Tumors for engraftment are…”
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Parabacteroides distasonis attenuates toll‐like receptor 4 signaling and Akt activation and blocks colon tumor formation in high‐fat diet‐fed azoxymethane‐treated mice by Koh, Gar Yee, Kane, Anne, Lee, Kyongbum, Xu, Qiaobing, Wu, Xian, Roper, Jatin, Mason, Joel B., Crott, Jimmy W.

“…Gut dysbiosis may play an etiological role in colorectal tumorigenesis. We previously observed that the abundance of Parabacteroides distasonis (Pd) in stool…”
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Loss of aryl hydrocarbon receptor potentiates FoxM1 signaling to enhance self‐renewal of colonic stem and progenitor cells by Han, Huajun, Davidson, Laurie A, Fan, Yang‐Yi, Goldsby, Jennifer S, Yoon, Grace, Jin, Un‐Ho, Wright, Gus A, Landrock, Kerstin K, Weeks, Bradley R, Wright, Rachel C, Allred, Clinton D, Jayaraman, Arul, Ivanov, Ivan, Roper, Jatin, Safe, Stephen H, Chapkin, Robert S

“…The aryl hydrocarbon receptor (AhR), a ligand‐activated transcription factor that senses xenobiotics, diet, and gut microbial‐derived metabolites, is…”
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Mutant APC reshapes Wnt signaling plasma membrane nanodomains by altering cholesterol levels via oncogenic β-catenin by Erazo-Oliveras, Alfredo, Muñoz-Vega, Mónica, Mlih, Mohamed, Thiriveedi, Venkataramana, Salinas, Michael L., Rivera-Rodríguez, Jaileen M., Kim, Eunjoo, Wright, Rachel C., Wang, Xiaoli, Landrock, Kerstin K., Goldsby, Jennifer S., Mullens, Destiny A., Roper, Jatin, Karpac, Jason, Chapkin, Robert S.

“…Although the role of the Wnt pathway in colon carcinogenesis has been described previously, it has been recently demonstrated that Wnt signaling originates…”
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Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer by Cheltsov, Anton, Nomura, Natsuko, Yenugonda, Venkata M., Roper, Jatin, Mukthavaram, Rajesh, Jiang, Pengfei, Her, Nam-Gu, Babic, Ivan, Kesari, Santosh, Nurmemmedov, Elmar

“…Abnormal regulation of β-catenin initiates an oncogenic program that serves as a main driver of many cancers. Albeit challenging, β-catenin is an attractive…”
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The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer by Roper, Jatin, Richardson, Michael P, Wang, Wei Vivian, Richard, Larissa Georgeon, Chen, Wei, Coffee, Erin M, Sinnamon, Mark J, Lee, Lydia, Chen, Peng-Chieh, Bronson, Roderick T, Martin, Eric S, Hung, Kenneth E

“…To examine the in vitro and in vivo efficacy of the dual PI3K/mTOR inhibitor NVP-BEZ235 in treatment of PIK3CA wild-type colorectal cancer (CRC). PIK3CA mutant…”
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The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin by Francois, Fritz, Roper, Jatin, Joseph, Neal, Pei, Zhiheng, Chhada, Aditi, Shak, Joshua R, de Perez, Asalia Z Olivares, Perez-Perez, Guillermo I, Blaser, Martin J

“…Appetite and energy expenditure are regulated in part by ghrelin and leptin produced in the gastric mucosa, which may be modified by H. pylori colonization. We…”
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In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis by Roper, Jatin, Tammela, Tuomas, Cetinbas, Naniye Malli, Akkad, Adam, Roghanian, Ali, Rickelt, Steffen, Almeqdadi, Mohammad, Wu, Katherine, Oberli, Matthias A, Sánchez-Rivera, Francisco J, Park, Yoona K, Liang, Xu, Eng, George, Taylor, Martin S, Azimi, Roxana, Kedrin, Dmitriy, Neupane, Rachit, Beyaz, Semir, Sicinska, Ewa T, Suarez, Yvelisse, Yoo, James, Chen, Lillian, Zukerberg, Lawrence, Katajisto, Pekka, Deshpande, Vikram, Bass, Adam J, Tsichlis, Philip N, Lees, Jacqueline, Langer, Robert, Hynes, Richard O, Chen, Jianzhu, Bhutkar, Arjun, Jacks, Tyler, Yilmaz, Ömer H

“…Metastatic progression of colorectal cancer is modeled in mice using in vivo genome editing and transplantation of engineered organoids. In vivo interrogation…”
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Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer by Roper, Jatin, Sinnamon, Mark J, Coffee, Erin M, Belmont, Peter, Keung, Lily, Georgeon-Richard, Larissa, Wang, Wei Vivian, Faber, Anthony C, Yun, Jihye, Yilmaz, Ömer H, Bronson, Roderick T, Martin, Eric S, Tsichlis, Philip N, Hung, Kenneth E

“…Abstract PI3K inhibition in combination with other agents has not been studied in the context of PIK3CA wild-type, KRAS mutant cancer. In a screen of…”
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Colorectal Cancer Immunotherapy: State of the Art and Future Directions by Cornista, Alyssa Mauri, Giolito, Maria Virginia, Baker, Kristi, Hazime, Hajar, Dufait, Inès, Datta, Jashodeep, Khumukcham, Saratchandra Singh, De Ridder, Mark, Roper, Jatin, Abreu, Maria T, Breckpot, Karine, Van der Jeught, Kevin

“…Cancer immunotherapy has become an indispensable mode of treatment for a multitude of solid tumor cancers. Colorectal cancer (CRC) has been one of the many…”
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Myxedema Ascites: An Unusual Presentation of Uncontrolled Hypothyroidism by Dhingra, Rohit, Rai, Puja, Sieker, Jakob, Roper, Jatin

“…We describe a case of myxedema ascites in a 64-year-old male with a history of hypothyroidism noncompliant with medical therapy who presented with syncope,…”
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