Search Results - "Roosild, Tarmo"

Active site conformational dynamics in human uridine phosphorylase 1 by Roosild, Tarmo P, Castronovo, Samantha

“…Uridine phosphorylase (UPP) is a central enzyme in the pyrimidine salvage pathway, catalyzing the reversible phosphorolysis of uridine to uracil and…”
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NMR Structure of Mistic, a Membrane-Integrating Protein for Membrane Protein Expression by Roosild, Tarmo P, Greenwald, Jason, Vega, Mark, Castronovo, Samantha, Riek, Roland, Choe, Senyon

“…Although structure determination of soluble proteins has become routine, our understanding of membrane proteins has been limited by experimental bottlenecks in…”
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Mechanism of ligand-gated potassium efflux in bacterial pathogens by Roosild, Tarmo P., Castronovo, Samantha, Healy, Jess, Miller, Samantha, Pliotas, Christos, Rasmussen, Tim, Bartlett, Wendy, Conway, Stuart J., Booth, Ian R., Rees, Douglas C.

“…Gram negative pathogens are protected against toxic electrophilic compounds by glutathione-gated potassium efflux systems (Kef) that modulate cytoplasmic pH…”
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A novel structural mechanism for redox regulation of uridine phosphorylase 2 activity by Roosild, Tarmo P., Castronovo, Samantha, Villoso, Adelbert, Ziemba, Amy, Pizzorno, Giuseppe

“…Uridine phosphorylase (UPP) catalyzes the reversible conversion of uridine to uracil and ribose-1-phosphate and plays an important pharmacological role in…”
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Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy by Roosild, Tarmo P, Castronovo, Samantha, Fabbiani, Michael, Pizzorno, Giuseppe

“…Uridine phosphorylase (UPP) is a key enzyme of pyrimidine salvage pathways, catalyzing the reversible phosphorolysis of ribosides of uracil to nucleobases and…”
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A Mechanism of Regulating Transmembrane Potassium Flux through a Ligand-Mediated Conformational Switch by Roosild, Tarmo P., Miller, Samantha, Booth, Ian R., Choe, Senyon

“…The regulation of cation content is critical for cell growth. However, the molecular mechanisms that gate the systems that control K + movements remain…”
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Cytoplasmic gatekeepers of K +-channel flux: a structural perspective by Roosild, Tarmo P, Lê, Khanh-Tuoc, Choe, Senyon

“…Recently, rapid progress in our structural knowledge of K +-selective channels has started to provide a basis for comprehending the biophysical machinery…”
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KTN (RCK) Domains Regulate K+ Channels and Transporters by Controlling the Dimer-Hinge Conformation by Roosild, Tarmo P., Castronovo, Samantha, Miller, Samantha, Li, Chan, Rasmussen, Tim, Bartlett, Wendy, Gunasekera, Banuri, Choe, Senyon, Booth, Ian R.

“…KTN (RCK) domains are nucleotide-binding folds that form the cytoplasmic regulatory complexes of various K+ channels and transporters. The mechanisms these…”
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Characterization of the family of Mistic homologues by Roosild, Tarmo P, Vega, Mark, Castronovo, Samantha, Choe, Senyon

“…Mistic is a unique Bacillus subtilis protein with virtually no detectable homologues in GenBank, which appears to integrate into the bacterial membrane despite…”
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Structure of anti-FLAG M2 Fab domain and its use in the stabilization of engineered membrane proteins by Roosild, Tarmo P., Castronovo, Samantha, Choe, Senyon

“…The inherent difficulties of stabilizing detergent‐solubilized integral membrane proteins for biophysical or structural analysis demand the development of new…”
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Redesigning an integral membrane K+ channel into a soluble protein by Roosild, Tarmo P., Choe, Senyon

“…Even though the structure determination of soluble proteins has become routine, the number of unrelated integral membrane protein structures remains at a few…”
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A Structure‐and‐Function‐Based Approach to Target Ryanodine Receptor 2 for Heart Failure by Sun, Qing, Roosild, Tarmo, Bobkov, Andrey, Ma, Chen-Ting, Holleran, John, Sergienko, Eduard

“…Abstract only Ryanodine receptor 2 (RYR2) controls transient calcium release (calcium spark) from the sarcoplasmic reticulum (SR) into the cytoplasm in…”
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Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase by Stanford, Stephanie M, Diaz, Michael A, Ardecky, Robert J, Zou, Jiwen, Roosild, Tarmo, Holmes, Zachary J, Nguyen, Tiffany P, Hedrick, Michael P, Rodiles, Socorro, Guan, April, Grotegut, Stefan, Santelli, Eugenio, Chung, Thomas D. Y, Jackson, Michael R, Bottini, Nunzio, Pinkerton, Anthony B

“…Obesity-associated insulin resistance plays a central role in the pathogenesis of type 2 diabetes. A promising approach to decrease insulin resistance in…”
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Structure-Guided Design of Novel Inhibitors of Human Uridine Phosphorylase 1 by Castronovo, Samantha, Pizzorno, Giuseppe, Roosild, Tarmo P.

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Activation and Complex Regulation of the Kef Potassium Efflux System During Protection of Bacteria Against Toxic Electrophiles by Rasmussen, Tim, Pliotas, Christos, Lyngberg, Lisbeth, Healy, Jess, Bartlett, Wendy, Miller, Samantha, Roosild, Tarmo P., Castronovo, Samantha, Conway, Stuart J., Booth, Ian R.

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Mechanism of Regulation of Kef Channels by Chemically Diverse Glutathione Molecules by Roosild, Tarmo P., Castronovo, Samantha, Healy, Jess, Miller, Samantha, Rasmussen, Tim, Bartlett, Wendy, Conway, Stuart, Booth, Ian R.

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Redesigning an integral membrane K super(+) channel into a soluble protein by Roosild, Tarmo P, Choe, Senyon

“…Even though the structure determination of soluble proteins has become routine, the number of unrelated integral membrane protein structures remains at a few…”
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Potassium channel structure: domain by domain by Biggin, Phil C, Roosild, Tarmo, Choe, Senyon

“…Since the determination of the structure of a bacterial potassium channel, the ion channel community has managed to gain momentum in the quest for a complete…”
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Regulation of the K channels by cytoplasmic domains by Choe, Senyon, Roosild, Tarmo

“…Regulation of intracellular potassium levels is one of the basic functions of all cells, controlling cellular osmolarity and transmitting information. In…”
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Structures of three diphtheria toxin repressor (DtxR) variants with decreased repressor activity by Pohl, Ehmke, Goranson-Siekierke, Joanne, Choi, Michael K., Roosild, Tarmo, Holmes, Randall K., Hol, Wim G. J.

“…The diphtheria toxin repressor (DtxR) from Corynebacterium diphtheriae regulates the expression of the gene on corynebacteriophages that encodes diphtheria…”
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