Search Results - "Rooseboom, Martijn"

Enzyme-Catalyzed Activation of Anticancer Prodrugs by Rooseboom, Martijn, Commandeur, Jan N M, Vermeulen, Nico P E

“…The rationale for the development of prodrugs relies upon delivery of higher concentrations of a drug to target cells compared to administration of the drug…”
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Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories by Hayeshi, Rose, Hilgendorf, Constanze, Artursson, Per, Augustijns, Patrick, Brodin, Birger, Dehertogh, Pascale, Fisher, Karen, Fossati, Lina, Hovenkamp, Egbert, Korjamo, Timo, Masungi, Chantal, Maubon, Nathalie, Mols, Raf, Müllertz, Anette, Mönkkönen, Jukka, O’Driscoll, Caitriona, Oppers-Tiemissen, H.M., Ragnarsson, Eva G.E., Rooseboom, Martijn, Ungell, Anna-Lena

“…Caco-2 cells, widely used to study carrier mediated uptake and efflux mechanisms, are known to have different properties when cultured under different…”
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Functional Replacement of Murine CXCR2 by Its Human Homologue in the Development of Atherosclerosis in LDLR Knockout Mice by Mihara, Katsuhiro, Spansier, Mirjam, Rooseboom, Martijn, Smit, Martin-Jan, Dokter, Wim

“…The CXC chemokine receptor CXCR2 has been implicated in the pathogenesis of several chronic diseases including atherosclerosis. To enable animal studies…”
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Human CXCR2 (hCXCR2) takes over functionalities of its murine homolog in hCXCR2 knockin mice by Mihara, Katsuhiro, Smit, Martin‐Jan, Krajnc‐Franken, Magda, Gossen, Jan, Rooseboom, Martijn, Dokter, Wim

“…Human CXCR2 (hCXCR2) has been implicated in diverse inflammatory diseases. When roles of this receptor studied in animal models are extrapolated into men,…”
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Recommendation for an occupational exposure limit for toluene by Rooseboom, Martijn, Kocabas, Neslihan Aygun, North, Colin, Radcliffe, Richard James, Segal, Lawrence

“…The Lower Olefins and Aromatics (LOA) REACH Consortium, which includes toluene registrants in the EU, established a Working Group (WG) to conduct a review of…”
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Application of physiologically-based pharmacokinetic modeled toluene blood concentration in the assessment of short term exposure limits by North, Colin M., Rooseboom, Martijn, Kocabas, Neslihan Aygun, Synhaeve, Nicholas, Radcliffe, Richard James, Segal, Lawrence

“…Toluene is a volatile hydrocarbon with solvent applications in several industries. Acute neurological effects in workers exposed to toluene have been reported…”
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Appraisal of the human health related toxicological information available on dicyclopentadiene (DCPD) in view of assessing the substance's potential to cause endocrine disruption by Tencalla, Francesca, Kocabas, Neslihan Aygun, Rooseboom, Martijn, Rushton, Erik, Synhaeve, Nicholas, Petry, Thomas

“…Dicyclopentadiene (DCPD) is an olefinic hydrocarbon which is manufactured and imported into the European Union (EU) at greater than 1000 tons per year…”
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Modes of action considerations in threshold expectations for health effects of benzene by North, Colin M., Rooseboom, Martijn, Kocabas, Neslihan Aygun, Schnatter, A. Robert, Faulhammer, Frank, Williams, Stephen D

“…[Display omitted] •Mutagenic mechanism, chemistry, and dose rate effects factor into benzene MOA.•Mechanistic and empirical evidence assist benzene MOA…”
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Micronuclei in human peripheral blood and bone marrow as genotoxicity markers: A systematic review and meta-analysis by Antoniou, Evangelia E., Rooseboom, Martijn, Kocabas, Neslihan A., North, Colin M., Zeegers, Maurice P.

“…Can human peripheral blood cells be used as a surrogate for bone marrow cells, in evaluating the genotoxic effects of stressors? We searched the Pubmed/Medline…”
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The short-term toxicity and metabolome of Benzene by Faulhammer, Frank, van Ravenzwaay, Bennard, Schnatter, A. Robert, Rooseboom, Martijn, Kamp, Hennicke, Flick, Burkhard, Giri, Varun, Sperber, Saskia, Higgins, Larry G., Penman, Michael G., Kocabas, Neslihan Aygun

“…A 14-day rat study with plasma metabolomics was conducted to evaluate the toxicity of Benzene. Wistar rats were orally administered Benzene daily at doses of…”
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The short-term toxicity and metabolome of dicyclopentadiene by van Ravenzwaay, Bennard, Kocabas, Neslihan Aygun, Faulhammer, Frank, Flick, Burkhard, Giri, Varun, Sperber, Saskia, Penman, Michael G., Higgins, Larry G., Kamp, Hennicke, Rooseboom, Martijn

“…Dicyclopentadiene (DCPD) was investigated in a 14-day oral rat toxicity study based on the OECD 407 guideline in combination with plasma metabolomics. Wistar…”
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Xylene: weight of evidence approach case study to determine the need for an extended one generation reproductive study with a developmental neurotoxicity animal cohort by Faulhammer, Frank, Rooseboom, Martijn, Kocabas, Neslihan Aygun, Arts, Josje H. E., Cordova, Alexandra, Freeman, Elaine, Higgins, Larry G., Nahar, Muna, Richmond, Emily, Schneider, Steffen, Morris-Schaffer, Keith

“…Xylene is a high production volume chemical that is widely used as a solvent and polymer precursor, and is currently undergoing substance evaluation under…”
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RespiraTox – Development of a QSAR model to predict human respiratory irritants by Wehr, Matthias M., Sarang, Satinder S., Rooseboom, Martijn, Boogaard, Peter J., Karwath, Andreas, Escher, Sylvia E.

“…Respiratory irritation is an important human health endpoint in chemical risk assessment. There are two established modes of action of respiratory irritation,…”
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“Commandeuring” Xenobiotic Metabolism: Advances in Understanding Xenobiotic Metabolism by van Vugt-Lussenburg, Barbara M. A., Capinha, Liliana, Reinen, Jelle, Rooseboom, Martijn, Kranendonk, Michel, Onderwater, Rob C. A., Jennings, Paul

“…The understanding of how exogenous chemicals (xenobiotics) are metabolized, distributed, and eliminated is critical to determine the impact of the chemical and…”
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The current status of exposure-driven approaches for chemical safety assessment: A cross-sector perspective by Sewell, Fiona, Aggarwal, Manoj, Bachler, Gerald, Broadmeadow, Alan, Gellatly, Nichola, Moore, Emma, Robinson, Sally, Rooseboom, Martijn, Stevens, Alexander, Terry, Claire, Burden, Natalie

“…For the purposes of chemical safety assessment, the value of using non-animal (in silico and in vitro) approaches and generating mechanistic information on…”
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Derivation of an occupational exposure limit for benzene using epidemiological study quality assessment tools by Schnatter, A. Robert, Rooseboom, Martijn, Kocabas, Neslihan Aygun, North, Colin M., Dalzell, Abigail, Twisk, Johannes, Faulhammer, Frank, Rushton, Erik, Boogaard, Peter J., Ostapenkaite, Viktorija, Williams, Stephen D.

“…•MOA points to a benzene OEL based on haematotoxicity and genotoxicity.•Quality scoring methods allow OELs to be based on methodologically-sound…”
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Key event-informed risk models for benzene-induced acute myeloid leukaemia by North, Colin M., Schnatter, A. Robert, Rooseboom, Martijn, Aygun Kocabas, Neslihan, Dalzell, Abigail, Williams, Stephen D.

“…•Key events in a mode of action can inform risk model shape.•Flexible approaches to modifying risk model shape are demonstrated and discussed.•Benzene leukemia…”
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DARTpaths, an in silico platform to investigate molecular mechanisms of compounds by Bhalla, Diksha, Steijaert, Marvin N, Poppelaars, Eefje S, Teunis, Marc, van der Voet, Monique, Corradi, Marie, Dévière, Elisabeth, Noothout, Luke, Tomassen, Wilco, Rooseboom, Martijn, Currie, Richard A, Krul, Cyrille, Pieters, Raymond, van Noort, Vera, Wildwater, Marjolein

“…Abstract Summary Xpaths is a collection of algorithms that allow for the prediction of compound-induced molecular mechanisms of action by integrating…”
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Application of Caenorhabditis elegans (nematode) and Danio rerio embryo (zebrafish) as model systems to screen for developmental and reproductive toxicity of Piperazine compounds by Racz, Peter I., Wildwater, Marjolein, Rooseboom, Martijn, Kerkhof, Engelien, Pieters, Raymond, Yebra-Pimentel, Elena Santidrian, Dirks, Ron P., Spaink, Herman P., Smulders, Chantal, Whale, Graham F.

“…To enable selection of novel chemicals for new processes, there is a recognized need for alternative toxicity screening assays to assess potential risks to man…”
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New Approach Methodologies for Human-Relevant Biokinetics Predictions: Meeting the Paradigm Shift in Toxicology Towards an Animal-Free Chemical Risk Assessment by Punt, Ans, Bouwmeester, Hans, Blaauboer, Bas J, Coecke, Sandra, Hakkert, Betty, Hendriks, Delilah F.G, Jennings, Paul, Kramer, Nynke I, Neuhoff, Sibylle, Masereeuw, Rosalinde, Paini, Alicia, Peijnenburg, Ad A.C.M, Rooseboom, Ma, Shuler, Michael L, Sorrell, Ian, Spee, Bart, Strikwold, Marije, van der Meer, Andries D, van der Zande, Meike, Vinken, Mathieu, Yang, Huan, Bos, Peter M.J, Heringa, Minne B

“…For almost fifteen years, the availability and regulatory acceptance of new approach methodologies (NAMs) to assess the absorption, distribution, metabolism…”
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