Search Results - "Roose‐Girma, Merone"

Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins by Lim, Junghyun, Park, Hyunjoo, Heisler, Jason, Maculins, Timurs, Roose-Girma, Merone, Xu, Min, Mckenzie, Brent, van Lookeren Campagne, Menno, Newton, Kim, Murthy, Aditya

“…RIPK1, RIPK3, ZBP1 and TRIF, the four mammalian proteins harboring RIP homotypic interaction motif (RHIM) domains, are key components of inflammatory signaling…”
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Intrinsic apoptosis shapes the tumor spectrum linked to inactivation of the deubiquitinase BAP1 by He, Meng, Chaurushiya, Mira S, Webster, Joshua D, Kummerfeld, Sarah, Reja, Rohit, Chaudhuri, Subhra, Chen, Ying-Jiun, Modrusan, Zora, Haley, Benjamin, Dugger, Debra L, Eastham-Anderson, Jeffrey, Lau, Shari, Dey, Anwesha, Caothien, Roger, Roose-Girma, Merone, Newton, Kim, Dixit, Vishva M

“…Malignancies arising from mutation of tumor suppressors have unexplained tissue proclivity. For example, encodes a widely expressed deubiquitinase for histone…”
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BMP1 is not required for lung fibrosis in mice by Ma, Hsiao-Yen, N’Diaye, Elsa-Noah, Caplazi, Patrick, Huang, Zhiyu, Arlantico, Alexander, Jeet, Surinder, Wong, Aaron, Brightbill, Hans D., Li, Qingling, Wong, Weng Ruth, Sandoval, Wendy, Tam, Lucinda, Newman, Robert, Roose-Girma, Merone, Ding, Ning

“…Bone morphogenetic protein 1 (BMP1) belongs to the astacin/BMP1/tolloid-like family of zinc metalloproteinases, which play a fundamental role in the…”
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Ubiquilin1 promotes antigen-receptor mediated proliferation by eliminating mislocalized mitochondrial proteins by Whiteley, Alexandra M, Prado, Miguel A, Peng, Ivan, Abbas, Alexander R, Haley, Benjamin, Paulo, Joao A, Reichelt, Mike, Katakam, Anand, Sagolla, Meredith, Modrusan, Zora, Lee, Dong Yun, Roose-Girma, Merone, Kirkpatrick, Donald S, McKenzie, Brent S, Gygi, Steven P, Finley, Daniel, Brown, Eric J

“…Ubiquilins (Ubqlns) are a family of ubiquitin receptors that promote the delivery of hydrophobic and aggregated ubiquitinated proteins to the proteasome for…”
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Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis by Newton, Kim, Wickliffe, Katherine E., Dugger, Debra L., Maltzman, Allie, Roose-Girma, Merone, Dohse, Monika, Kőműves, László, Webster, Joshua D., Dixit, Vishva M.

“…The aspartate-specific cysteine protease caspase-8 suppresses necroptotic cell death mediated by RIPK3 and MLKL. Indeed, mice that lack caspase-8 die in a…”
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Activity of caspase-8 determines plasticity between cell death pathways by Newton, Kim, Wickliffe, Katherine E., Maltzman, Allie, Dugger, Debra L., Reja, Rohit, Zhang, Yue, Roose-Girma, Merone, Modrusan, Zora, Sagolla, Meredith S., Webster, Joshua D., Dixit, Vishva M.

“…Caspase-8 is a protease with both pro-death and pro-survival functions: it mediates apoptosis induced by death receptors such as TNFR1 1 , and suppresses…”
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Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP by Zhou, Yi, Fei, Mingjian, Zhang, Gu, Liang, Wei-Ching, Lin, WeiYu, Wu, Yan, Piskol, Robert, Ridgway, John, McNamara, Erin, Huang, Haochu, Zhang, Juan, Oh, Jaehak, Patel, Jaina M., Jakubiak, Diana, Lau, Jeff, Blackwood, Beth, Bravo, Daniel D., Shi, Yongchang, Wang, Jianyong, Hu, Hong-Ming, Lee, Wyne P., Jesudason, Rajiv, Sangaraju, Dewakar, Modrusan, Zora, Anderson, Keith R., Warming, Søren, Roose-Girma, Merone, Yan, Minhong

“…Clearance of apoptotic cells by macrophages prevents excessive inflammation and supports immune tolerance. Here, we examined the effect of blocking apoptotic…”
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Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury by Chung, Jun-Jae, Goldstein, Leonard, Chen, Ying-Jiun J, Lee, Jiyeon, Webster, Joshua D, Roose-Girma, Merone, Paudyal, Sharad C, Modrusan, Zora, Dey, Anwesha, Shaw, Andrey S

“…The glomerulus is a specialized capillary bed that is involved in urine production and BP control. Glomerular injury is a major cause of CKD, which is epidemic…”
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Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death by Kist, Matthias, Kőműves, László G., Goncharov, Tatiana, Dugger, Debra L., Yu, Charles, Roose-Girma, Merone, Newton, Kim, Webster, Joshua D., Vucic, Domagoj

“…Receptor-interacting protein 1 (RIP1; RIPK1) is a key regulator of multiple signaling pathways that mediate inflammatory responses and cell death. TNF-TNFR1…”
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Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation by Lee, Bettina L, Stowe, Irma B, Gupta, Aaron, Kornfeld, Opher S, Roose-Girma, Merone, Anderson, Keith, Warming, Søren, Zhang, Juan, Lee, Wyne P, Kayagaki, Nobuhiko

“…Intracellular LPS sensing by caspase-4/5/11 triggers proteolytic activation of pore-forming gasdermin D (GSDMD), leading to pyroptotic cell death in…”
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A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3 by Murthy, Aditya, Li, Yun, Peng, Ivan, Reichelt, Mike, Katakam, Anand Kumar, Noubade, Rajkumar, Roose-Girma, Merone, DeVoss, Jason, Diehl, Lauri, Graham, Robert R., van Lookeren Campagne, Menno

“…Crohn’s disease is a debilitating inflammatory bowel disease (IBD) that can involve the entire digestive tract. A single-nucleotide polymorphism (SNP) encoding…”
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Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases by Meunier, Etienne, Dick, Mathias S., Dreier, Roland F., Schürmann, Nura, Broz, Daniela Kenzelmann, Warming, Søren, Roose-Girma, Merone, Bumann, Dirk, Kayagaki, Nobuhiko, Takeda, Kiyoshi, Yamamoto, Masahiro, Broz, Petr

“…Interferon-inducible GTPases are required for the release of vacuolar Gram-negative bacteria into the cytoplasm and subsequent inflammasome-mediated caspase-11…”
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Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis by Newton, Kim, Dugger, Debra L., Wickliffe, Katherine E., Kapoor, Neeraj, de Almagro, M. Cristina, Vucic, Domagoj, Komuves, Laszlo, Ferrando, Ronald E., French, Dorothy M., Webster, Joshua, Roose-Girma, Merone, Warming, Søren, Dixit, Vishva M.

“…Receptor-interacting protein kinase 1 (RIPK1) and RIPK3 trigger pro-inflammatory cell death termed "necroptosis." Studies with RIPK3-deficient mice or the…”
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CRISPR off-target analysis in genetically engineered rats and mice by Anderson, Keith R., Haeussler, Maximilian, Watanabe, Colin, Janakiraman, Vasantharajan, Lund, Jessica, Modrusan, Zora, Stinson, Jeremy, Bei, Qixin, Buechler, Andrew, Yu, Charles, Thamminana, Sobha R., Tam, Lucinda, Sowick, Michael-Anne, Alcantar, Tuija, O’Neil, Natasha, Li, Jinjie, Ta, Linda, Lima, Lisa, Roose-Girma, Merone, Rairdan, Xin, Durinck, Steffen, Warming, Søren

“…Despite widespread use of CRISPR, comprehensive data on the frequency and impact of Cas9-mediated off-targets in modified rodents are limited. Here we present…”
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NRF2 activates growth factor genes and downstream AKT signaling to induce mouse and human hepatomegaly by He, Feng, Antonucci, Laura, Yamachika, Shinichiro, Zhang, Zechuan, Taniguchi, Koji, Umemura, Atsushi, Hatzivassiliou, Georgia, Roose-Girma, Merone, Reina-Campos, Miguel, Duran, Angeles, Diaz-Meco, Maria T., Moscat, Jorge, Sun, Beicheng, Karin, Michael

“…Hepatomegaly can be triggered by insulin and insulin-unrelated etiologies. Insulin acts via AKT, but how other challenges cause hepatomegaly is unknown. Since…”
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OTULIN limits cell death and inflammation by deubiquitinating LUBAC by Heger, Klaus, Wickliffe, Katherine E., Ndoja, Ada, Zhang, Juan, Murthy, Aditya, Dugger, Debra L., Maltzman, Allie, de Sousa e Melo, Felipe, Hung, Jeffrey, Zeng, Yi, Verschueren, Erik, Kirkpatrick, Donald S., Vucic, Domagoj, Lee, Wyne P., Roose-Girma, Merone, Newman, Robert J., Warming, Søren, Hsiao, Yi-Chun, Kőműves, László G., Webster, Joshua D., Newton, Kim, Dixit, Vishva M.

“…OTULIN (OTU deubiquitinase with linear linkage specificity) removes linear polyubiquitin from proteins that have been modified by LUBAC (linear ubiquitin chain…”
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Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues by Kapoor, Varun N., Müller, Sören, Keerthivasan, Shilpa, Brown, Markus, Chalouni, Cecile, Storm, Elaine E., Castiglioni, Alessandra, Lane, Ryan, Nitschke, Maximilian, Dominguez, Claudia X., Astarita, Jillian L., Krishnamurty, Akshay T., Carbone, Catherine B., Senbabaoglu, Yasin, Wang, Amber W., Wu, Xiumin, Cremasco, Viviana, Roose-Girma, Merone, Tam, Lucinda, Doerr, Jonas, Chen, Mark Z., Lee, Wyne P., Modrusan, Zora, Yang, Yeqing Angela, Bourgon, Richard, Sandoval, Wendy, Shaw, Andrey S., de Sauvage, Frederic J., Mellman, Ira, Moussion, Christine, Turley, Shannon J.

“…Fibroblastic reticular cells (FRCs) are specialized stromal cells that define tissue architecture and regulate lymphocyte compartmentalization, homeostasis,…”
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Ubiquitin Ligases cIAP1 and cIAP2 Limit Cell Death to Prevent Inflammation by Zhang, Jieqiong, Webster, Joshua D., Dugger, Debra L., Goncharov, Tatiana, Roose-Girma, Merone, Hung, Jeffrey, Kwon, Youngsu C., Vucic, Domagoj, Newton, Kim, Dixit, Vishva M.

“…Cellular inhibitor of apoptosis proteins cIAP1 and cIAP2 ubiquitinate nuclear factor κB (NF-κB)-inducing kinase (NIK) to suppress non-canonical NF-κB signaling…”
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Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity by Barreira da Silva, Rosa, Leitao, Ricardo M., Pechuan-Jorge, Ximo, Werneke, Scott, Oeh, Jason, Javinal, Vincent, Wang, Yingyun, Phung, Wilson, Everett, Christine, Nonomiya, Jim, Arnott, David, Lu, Cheng, Hsiao, Yi-Chun, Koerber, James T., Hötzel, Isidro, Ziai, James, Modrusan, Zora, Pillow, Thomas H., Roose-Girma, Merone, Schartner, Jill M., Merchant, Mark, Rutz, Sascha, Eidenschenk, Céline, Mellman, Ira, Albert, Matthew L.

“…Tumor-associated macrophages are composed of distinct populations arising from monocytes or tissue macrophages, with a poorly understood link to disease…”
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Context-dependent signaling defines roles of BMP9 and BMP10 in embryonic and postnatal development by Chen, Hao, Ridgway, John Brady, Sai, Tao, Lai, Joyce, Warming, Søren, Chen, Hanying, Roose-Girma, Merone, Zhang, Gu, Shou, Weinian, Yan, Minhong

“…Many important signaling pathways rely on multiple ligands. It is unclear if this is a mechanism of safeguard via redundancy or if it serves other functional…”
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