Prefrontal cortex oxygenation during a mentally fatiguing task in normoxia and hypoxia

Mental fatigue (MF) and hypoxia impair cognitive performance through changes in brain hemodynamics. We want to elucidate the role of prefrontal cortex (PFC)-oxygenation in MF. Twelve participants (22.9 ± 3.5 years) completed four experimental trials, (1) MF in (normobaric) hypoxia (MF_HYP) (3.800 m;...

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Bibliographic Details
Published in:	Experimental brain research Vol. 242; no. 7; pp. 1807 - 1819
Main Authors:	De Wachter, Jonas, Roose, Manon, Proost, Matthias, Habay, Jelle, Verstraelen, Matthias, De Bock, Sander, De Pauw, Kevin, Meeusen, Romain, Van Cutsem, Jeroen, Roelands, Bart
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-07-2024 Springer Nature B.V
Subjects:	Adult Biomedical and Life Sciences Biomedicine Cognitive ability Female Heart rate Heart Rate - physiology Hemodynamics Hemoglobin Humans Hypoxia Hypoxia - metabolism Hypoxia - physiopathology Infrared spectroscopy Male Mental Fatigue - metabolism Mental Fatigue - physiopathology Neurology Neuropsychological Tests Neurosciences Oxygen - blood Oxygen - metabolism Oxygenation Prefrontal cortex Prefrontal Cortex - metabolism Prefrontal Cortex - physiology Psychomotor Performance - physiology Research Article Spectroscopy, Near-Infrared Stroop Test Vigilance Young Adult Normoxia Hypoxia Functional near infrared spectroscopy Cognitive fatigue Brain oxygenation
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Summary:	Mental fatigue (MF) and hypoxia impair cognitive performance through changes in brain hemodynamics. We want to elucidate the role of prefrontal cortex (PFC)-oxygenation in MF. Twelve participants (22.9 ± 3.5 years) completed four experimental trials, (1) MF in (normobaric) hypoxia (MF_HYP) (3.800 m; 13.5%O 2 ), (2) MF in normoxia (MF_NOR) (98 m; 21.0%O 2 ), (3) Control task in HYP (CON_HYP), (4) Control in NOR (CON_NOR). Participants performed a 2-back task, Digit Symbol Substitution test and Psychomotor Vigilance task before and after a 60-min Stroop task or an emotionally neutral documentary. Brain oxygenation was measured through functional Near Infrared Spectroscopy. Subjective feelings of MF and physiological measures (heart rate, oxygen saturation, blood glucose and hemoglobin) were recorded. The Stroop task resulted in increased subjective feelings of MF compared to watching the documentary. 2-back accuracy was lower post task compared to pre task in MF_NOR and CON_NOR, while no differences were found in the other cognitive tasks. The fraction of inspired oxygen did not impact feelings of MF. Although performing the Stroop resulted in higher subjective feelings of MF, hypoxia had no effect on the severity of self-reported MF. Additionally, this study could not provide evidence for a role of oxygenation of the PFC in the build-up of MF.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Communicated by Bill J Yates.
ISSN:	0014-4819 1432-1106 1432-1106
DOI:	10.1007/s00221-024-06867-y