Search Results - "Roos, Peter H."

Extrahepatic metabolism at the body's internal-external interfaces by Gundert-Remy, Ursula, Bernauer, Ulrike, Blömeke, Brunhilde, Döring, Barbara, Fabian, Eric, Goebel, Carsten, Hessel, Stefanie, Jäckh, Christine, Lampen, Alfonso, Oesch, Franz, Petzinger, Ernst, Völkel, Wolfgang, Roos, Peter H.

“…Abstract In general, xenobiotic metabolizing enzymes (XMEs) are expressed in lower levels in the extrahepatic tissues than in the liver, making the former less…”
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Cytochrome P450 interactions in human cancers: new aspects considering CYP1B1 by Roos, Peter H, Bolt, Hermann M

“…Molecular epidemiological studies are now a powerful tool to determine differential genetic susceptibilities to cancer-causing agents, and to obtain…”
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The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine by BOLT, Hermann M, ROOS, Peter H, THIER, Ricarda

“…The importance of the isoform CYP2E1 of the human cytochrome P-450 superfamily of enzymes for occupational and environmental medicine is derived from its…”
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Methods for the discovery of low-abundance biomarkers for urinary bladder cancer in biological fluids by Roos, Peter H, Jakubowski, Norbert

“…For the study of bladder cancer and the identification of respective tumor markers, blood and, in particular, urine constitute suitable sources of biological…”
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Markers of genetic susceptibility in human environmental hygiene and toxicology: The role of selected CYP, NAT and GST genes by Thier, Ricarda, Brüning, Thomas, Roos, Peter H., Rihs, Hans-Peter, Golka, Klaus, Ko, Yon, Bolt, Hermann M.

“…Inherited genetic traits co-determine the susceptibility of an individual to a toxic chemical. Special emphasis has been put on individual responses to…”
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Increased CYP1A1 expression in human exfoliated urothelial cells of cigarette smokers compared to non-smokers by DÖRRENHAUS, Angelika, MÜLLER, Tina, ROOS, Peter H

“…Polycyclic aromatic hydrocarbons, arylamines and nitrosamines, constituents of cigarette smoke, are known inducers of bladder cancer. The biochemical response…”
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A multi-parametric microarray for protein profiling: simultaneous analysis of 8 different cytochromes via differentially element tagged antibodies and laser ablation ICP-MS by Waentig, Larissa, Techritz, Sandra, Jakubowski, Norbert, Roos, Peter H

“…The paper presents a new multi-parametric protein microarray embracing the multi-analyte capabilities of laser ablation inductively coupled plasma mass…”
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Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2 by Niestroy, Jeanette, Barbara, Alfonso, Herbst, Kathrin, Rode, Sandra, van Liempt, Manuela, Roos, Peter H.

“…As phytochemicals have the potential to counteract adverse effects of carcinogens we investigated the influence of the flavonoids quercetin and kaempferol on…”
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Detection of electrophoretically separated cytochromes P450 by element-labelled monoclonal antibodies via laser ablation inductively coupled plasma mass spectrometry by Roos, Peter H, Venkatachalam, Arunachalam, Manz, Andreas, Waentig, Larissa, Koehler, Christina U, Jakubowski, Norbert

“…Numerous structurally and enzymatically similar cytochromes P450 (CYPs) are involved in the metabolism of xenobiotics and are present in different amounts and…”
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Cytochromes--fascinating molecular machines by Roos, Peter H, Jakubowski, Norbert

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Focus on the intermediate state: immature mRNA of cytochromes P450--methods and insights by Köhler, Christina U, Roos, Peter H

“…The scattered and limited data on hnRNAs (pre-mRNAs) of cytochromes P450 (CYP) are compiled and discussed for the first time. The methods for determination and…”
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Ethanol enhanced the genotoxicity of acrylamide in human, metabolically competent HepG2 cells by CYP2E1 induction and glutathione depletion by Lamy, Evelyn, Völkel, Yvonne, Roos, Peter H., Kassie, Fekadu, Mersch-Sundermann, Volker

“…In the present study, the genotoxicity of acrylamide (AA) was investigated in HepG2 cells using SCGE. Additionally, the influence of ethanol on the modulation…”
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Synergism of aromatic amines and benzo[a]pyrene in induction of Ah receptor-dependent genes by Borza, Alexandra, Plöttner, Sabine, Wolf, Alexander, Behm, Claudia, Selinski, Silvia, Hengstler, Jan G, Roos, Peter H, Bolt, Hermann M, Kuhlmann, Jürgen, Föllmann, Wolfram

“…Aromatic amines have been shown to cause bladder cancer. However, epithelial cells of the urinary bladder, cells of origin of bladder cancer, may be exposed to…”
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Perfluorinated compounds (PFC) hit the headlines: Meeting report on a satellite symposium of the annual meeting of the German Society of Toxicology by Roos, Peter H., Angerer, Jürgen, Dieter, Hermann, Wilhelm, Michael, Wölfle, Detlef, Hengstler, Jan G.

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Analysis of CYP1A1 induction in single cells of urothelial cell populations by flow cytometry by Plöttner, Sabine, Degen, Gisela H, Roos, Peter H, Föllmann, Wolfram

“…As carcinogenesis is a process starting at the single-cell level it is desirable to study carcinogen-mediated effects in individual cells. A primary step in…”
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Distinct subtypes of urinary bladder epithelial cells with inducible and non-inducible cytochrome P450 1A1 by Plöttner, Sabine, Selinski, Silvia, Bolt, Hermann M, Degen, Gisela H, Hengstler, Jan G, Roos, Peter H, Föllmann, Wolfram

“…Cultured primary porcine urinary bladder epithelial cells (PUBEC) represent an adequate and easy to handle in vitro system for studies of urothelial toxicity…”
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Concomitant detection of CYP1A1 enzymatic activity and CYP1A1 protein in individual cells of a human urothelial cell line using a bilayer microfluidic device by Schumann, Claus A, Dörrenhaus, Angelika, Franzke, Joachim, Lampen, Peter, Dittrich, Petra S, Manz, Andreas, Roos, Peter H

“…To understand molecular networking at the cellular level, analyses of processes and effects at the single-cell level are most appropriate. Usual biochemical or…”
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Expression and Inducibility of Cytochrome P450 3A9 (CYP3A9)and Other Members of the CYP3A Subfamily in Rat Liver by Mahnke, Axel, Strotkamp, Dagmar, Roos, Peter H., Hanstein, Walter G., Chabot, Guy G., Nef, Patrick

“…Quantitative reverse-transcriptase polymerase chain reaction was used to determine the content of mRNA derived from four CYP3A genes (CYP3A2, CYP3A9,…”
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Differential induction of CYP1A1 in duodenum, liver and kidney of rats after oral intake of soil containing polycyclic aromatic hydrocarbons by ROOS, Peter H

“…We have analyzed the induction of the cytochrome P450 enzyme CYP1A1 as a biomarker of effect in duodenum, liver and kidney of rats after oral intake of…”
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Risk potentials for humans of original and remediated PAH-contaminated soils: application of biomarkers of effect by Roos, Peter H., Tschirbs, Sebastian, Pfeifer, Frank, Welge, Peter, Hack, Alfons, Wilhelm, Michael, Bolt, Hermann M.

“…Contaminated soils represent a potential health risk for the human population. Risk assessment for humans requires specific methods, which must reflect the…”
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