Search Results - "Roos, PH"

Synergistic effects of benzo[a]pyrene and aromatic amines on AhR- and NFkB-signal transduction in urothelial cells by Herbst, K., Roos, P.H.

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Markers of genetic susceptibility in human environmental hygiene and toxicology: The role of selected CYP, NAT and GST genes by Thier, Ricarda, Brüning, Thomas, Roos, Peter H., Rihs, Hans-Peter, Golka, Klaus, Ko, Yon, Bolt, Hermann M.

“…Inherited genetic traits co-determine the susceptibility of an individual to a toxic chemical. Special emphasis has been put on individual responses to…”
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Expression and Inducibility of Cytochrome P450 3A9 (CYP3A9)and Other Members of the CYP3A Subfamily in Rat Liver by Mahnke, Axel, Strotkamp, Dagmar, Roos, Peter H., Hanstein, Walter G., Chabot, Guy G., Nef, Patrick

“…Quantitative reverse-transcriptase polymerase chain reaction was used to determine the content of mRNA derived from four CYP3A genes (CYP3A2, CYP3A9,…”
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Differential induction of CYP1A1 in duodenum, liver and kidney of rats after oral intake of soil containing polycyclic aromatic hydrocarbons by ROOS, Peter H

“…We have analyzed the induction of the cytochrome P450 enzyme CYP1A1 as a biomarker of effect in duodenum, liver and kidney of rats after oral intake of…”
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Risk potentials for humans of original and remediated PAH-contaminated soils: application of biomarkers of effect by Roos, Peter H., Tschirbs, Sebastian, Pfeifer, Frank, Welge, Peter, Hack, Alfons, Wilhelm, Michael, Bolt, Hermann M.

“…Contaminated soils represent a potential health risk for the human population. Risk assessment for humans requires specific methods, which must reflect the…”
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Vinclozolin, a widely used fungizide, enhanced BaP-induced micronucleus formation in human derived hepatoma cells by increasing CYP1A1 expression by Wu, Xin-jiang, Lu, Wen-qing, Roos, Peter H., Mersch-Sundermann, Volker

“…Vinclozolin, a widely used fungicide, can be identified as a residue in numerous vegetable and fruit samples. To get insight in its genetic toxicity, we…”
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Expression of cytochrome P450 enzymes CYP1A1, CYP1B1, CYP2E1 and CYP4B1 in cultured transitional cells from specimens of the human urinary tract and from urinary sediments by ROOS, P. H, BELIK, R, FÖLLMANN, W, DEGEN, G. H, KNOPF, H. J, BOLT, H. M, GOLKA, K

“…Expression of cytochromes P450 CYP1A1, CYP1B1, CYP2E1 and CYP4B1 was analysed on the transcript level in human urothelial cells obtained by various methods. As…”
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Improvements in Culturing Exfoliated Urothelial Cells In Vitro from Human Urine by Belik, Rouslana, Föllmann, Wolfram, Degen, Gisela H., Roos, Peter H., Blaszkewicz, Meinolf, Knopf, H. Jürgen, Golka, Klaus

“…Human bladder cancer is a common malignant tumor that may be produced by factors such as lifestyle, environment and occupation. The aim of this study was to…”
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Occupational exposure to polycyclic aromatic hydrocarbons suppresses constitutive expression of CYP1B1 on the transcript level in human leukocytes by Lemm, Friederike, Wilhelm, Michael, Roos, Peter H.

“…Expression patterns of the cytochromes P450 CYP1A1 and CYP1B1 have been analyzed on the transcript level in leukocytes of persons (n=30) occupationally exposed…”
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Different mechanisms of handling ingested polycyclic aromatic hydrocarbons in mammalian species: organ-specific response patterns of CYP1A1-induction after oral intake of PAH-contaminated soils by Roos, P. H., Tschirbs, S., Hack, A., Welge, P., Wilhelm, M.

“…Potential effects of xenobiotics on humans are largely derived from studies with animal models. However, due to species-specific processing of xenobiotics,…”
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Induction of cytochrome P450 1A1 in multiple organs of minipigs after oral exposure to soils contaminated with polycyclic aromatic hydrocarbons (PAH) by ROOS, Peter H, TSCHIRBS, Sebastian, WELGE, Peter, HACK, Alfons, THEEGARTEN, Dirk, MOGILEVSKI, Grigori, WILHELM, Michael

“…We have used the minipig as a prospective animal model for human risk characterization to study primary biochemical alterations upon oral contaminant intake…”
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Common multiple interactions of tricyclic anti-depressants and orphenadrine with liver microsomal cytochrome P450 enzymes of the rat by Roos, P H

“…1. Interactions of tricylic anti-depressants (TCA) and structurally related drugs with rat microsomal cytochromes P450 were studied including competitive…”
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Common multiple interactions of tricyclic antidepressants and orphenadrine with liver microsomal cytochrome P450 enzymes of the rat by ROOS, P. H.

“…1. Interactions of tricylic anti-depressants (TCA) and structurally related drugs with rat microsomal cytochromes P450 were studied including competitive…”
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Metabolite complex formation of orphenadrine with cytochrome P450: Involvement of CYP2C11 and CYP3A isozymes by Roos, Peter H., Mahnke, Axel

“…Expression and inhibition of cytochrome P450 (CYP) isozymes capable of forming an orphenadrine metabolite complex were studied in microsomes of untreated and…”
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Evaluation of Alternative Configurations for Shipping Low-Level Radioactive Waste to the Nevada Test Site by Siebach, PR, Daling, P M, Roos, PH, Biwer, B M

“…The Nevada Test Site (NTS) is a major receiver of United States Department of Energy (DOE)-owned low-level radioactive waste (LLW) for disposal. This paper…”
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In vivo induction of cytochrome P450 CYP3A expression in rat leukocytes using various inducers by Mahnke, A., Roos, P.H., Hanstein, W.G., Chabot, G.G.

“…Although the induction of cytochromes P450 3A (CYP3A) is relatively well characterized in liver, its inducibility in an easily available tissue such as the…”
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Formation of ligand and metabolite complexes as a means for selective quantitation of cytochrome P450 isozymes by Roos, P H, Golub-Ciosk, B, Kallweit, P, Kauczinski, D, Hanstein, W G

“…The suitability of triacetyloleandomycin (TAO) metabolite complex formation and metyrapone binding to reduced cytochrome P450 as a means for selective isozyme…”
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A membrane-associated form of C-reactive protein is the galactose- specific particle receptor on rat liver macrophages by Kempka, G, Roos, PH, Kolb-Bachofen, V

“…Rat liver macrophages express a galactose-specific receptor which mediates endocytosis of particles or neuraminidase-treated blood cells. From rat serum we now…”
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Liver microsomal levels of cytochrome P450IA1 as biomarker for exposure and bioavailability of soil-bound polycyclic aromatic hydrocarbons by ROOS, P. H, VAN AFFERDEN, M, STROTKAMP, D, TAPPE, D, PFEIFER, F, HANSTEIN, W. G

“…The bioavailability of soil-bound polycyclic aromatic hydrocarbons (PAHs) for mammalian species was studied with rats fed with a diet containing contaminated…”
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Purification and Characterization of a Cytochrome P450 Enzyme from Pig Liver, Catalyzing the Phenol Oxidative Coupling of (R)-Reticuline to Salutaridine, the Critical Step in Morphine Biosynthesis by H. Zenk, Meinhart, Amann, Tobias, H. Ross, Peter, Huh, Hoon

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