Search Results - "Roos, Jack"

The Orai Ca2+ channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis by Waldron, Richard T., Chen, Yafeng, Pham, Hung, Go, Ariel, Su, Hsin‐Yuan, Hu, Cheng, Wen, Li, Husain, Sohail Z., Sugar, Catherine A., Roos, Jack, Ramos, Stephanie, Lugea, Aurelia, Dunn, Michael, Stauderman, Kenneth, Pandol, Stephen J.

“…Key points This work confirms previous reports that CM4620, a small molecule inhibitor of Ca2+ entry via store operated Ca2+ entry (SOCE) channels formed by…”
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Cumulative review of hypertension in patients with chronic lymphocytic leukemia treated with acalabrutinib by Ferrajoli, Alessandra, Follows, George, Marmor, Yotvat, Roos, Jack, Bajwa, Naghmana, Madhira, Venkata, Nozaki, Kenji, Miranda, Paulo, Pennap, Dinci, Patel, Krish

“…Not available.Not available…”
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Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models by Wen, Li, Voronina, Svetlana, Javed, Muhammad A, Awais, Muhammad, Szatmary, Peter, Latawiec, Diane, Chvanov, Michael, Collier, David, Huang, Wei, Barrett, John, Begg, Malcolm, Stauderman, Ken, Roos, Jack, Grigoryev, Sergey, Ramos, Stephanie, Rogers, Evan, Whitten, Jeff, Velicelebi, Gonul, Dunn, Michael, Tepikin, Alexei V, Criddle, David N, Sutton, Robert

“…Background & Aims Sustained activation of the cytosolic calcium concentration induces injury to pancreatic acinar cells and necrosis. The calcium…”
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Genome-wide RNAi screen of Ca2+ influx identifies genes that regulate Ca2+ release-activated Ca2+ channel activity by Zhang, S., Yeromin, A., Zhang, X. H.-F., Yu, Y., Safrina, O., Penna, A., Roos, J., Stauderman, K., Cahalan, M.

“…Recent studies by our group and others demonstrated a required and conserved role of Stim in store-operated Ca 2+ influx and Ca 2+ release-activated Ca 2+…”
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STIM1, an essential and conserved component of store-operated Ca²⁺ channel function by Roos, Jack, DiGregorio, Paul J, Yeromin, Andriy V, Ohlsen, Kari, Lioudyno, Maria, Zhang, Shenyuan, Safrina, Olga, Kozak, J. Ashot, Wagner, Steven L, Cahalan, Michael D, Veliçelebi, Gönůl, Stauderman, Kenneth A

“…Store-operated Ca²⁺ (SOC) channels regulate many cellular processes, but the underlying molecular components are not well defined. Using an RNA interference…”
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Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation by Lioudyno, Maria I, Kozak, J. Ashot, Penna, Aubin, Safrina, Olga, Zhang, Shenyuan L, Sen, Debasish, Roos, Jack, Stauderman, Kenneth A, Cahalan, Michael D

“…For efficient development of an immune response, T lymphocytes require long-lasting calcium influx through calcium release-activated calcium (CRAC) channels…”
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Drosophila Futsch/22C10 Is a MAP1B-like Protein Required for Dendritic and Axonal Development by Hummel, Thomas, Krukkert, Karin, Roos, Jack, Davis, Graeme, Klämbt, Christian

“…Here we report the description of the Drosophila gene futsch, which encodes a protein recognized by the monoclonal antibody 22C10 that has been widely used to…”
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Synaptojanin Is Recruited by Endophilin to Promote Synaptic Vesicle Uncoating by Verstreken, Patrik, Koh, Tong-Wey, Schulze, Karen L., Zhai, R.Grace, Hiesinger, P.Robin, Zhou, Yi, Mehta, Sunil Q., Cao, Yu, Roos, Jack, Bellen, Hugo J.

“…We describe the isolation and characterization of Drosophila synaptojanin (synj) mutants. synj encodes a phosphatidylinositol phosphatase involved in…”
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Dap160/Intersectin Scaffolds the Periactive Zone to Achieve High-Fidelity Endocytosis and Normal Synaptic Growth by Marie, Bruno, Sweeney, Sean T, Poskanzer, Kira E, Roos, Jack, Kelly, Regis B, Davis, Graeme W

“…Dap160/Intersectin is a multidomain adaptor protein that colocalizes with endocytic machinery in the periactive zone at the Drosophila NMJ. We have generated…”
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Drosophila Futsch Regulates Synaptic Microtubule Organization and Is Necessary for Synaptic Growth by Roos, Jack, Hummel, Thomas, Ng, Norman, Klämbt, Christian, Davis, Graeme W.

“…We present evidence that Futsch, a novel protein with MAP1B homology, controls synaptic growth at the Drosophila neuromuscular junction through the regulation…”
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The endocytic machinery in nerve terminals surrounds sites of exocytosis by Roos, Jack, Kelly, Regis B.

“…In most models of endocytosis, the endocytic machinery is recruited from the cytoplasm by cytoplasmic tails of the plasma membrane proteins that are to be…”
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P642: A MATCHING‐ADJUSTED INDIRECT COMPARISON OF THE EFFICACY AND SAFETY OF ACALABRUTINIB VERSUS ZANUBRUTINIB IN RELAPSED OR REFRACTORY CHRONIC LYMPHOCYTIC LEUKEMIA by Skarbnik, Alan, Kittai, Adam, Miranda, Miguel, Yong, Alan, Roos, Jack, Hettle, Robert, Palazuelos‐Munoz, Sarah, Shetty, Vikram, Ghia, Paolo

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A store-operated calcium channel in Drosophila S2 cells by Yeromin, Andriy V, Roos, Jack, Stauderman, Kenneth A, Cahalan, Michael D

“…Using whole-cell recording in Drosophila S2 cells, we characterized a Ca(2+)-selective current that is activated by depletion of intracellular Ca2+ stores…”
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Acrue: A Phase 2, Open-Label Study of Acalabrutinib in Combination with Rituximab in Elderly and/or Frail Patients with Treatment-Naive Diffuse Large B-Cell Lymphoma by Perini, Guilherme F, Graff, Tara, Roos, Jack, Hermann, Richard, Lovenklev, Magnus, Shaw, Bob, Budde, L. Elizabeth

“…Background and Significance: Patients aged ≥80 years with diffuse large B-cell lymphoma (DLBCL) account for approximately 18% of DLBCL cases in the United…”
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Matching-Adjusted Indirect Comparisons of the Efficacy and Safety of Acalabrutinib Versus Ibrutinib in Relapsed/Refractory Mantle Cell Lymphoma by Gaitonde, Priyanka, Cai, Ling, de Miranda, Paulo, Roos, Jack, Rule, Simon, Wang, Michael L.

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The OST4 Gene of Saccharomyces cerevisiae Encodes an Unusually Small Protein Required for Normal Levels of Oligosaccharyltransferase Activity (∗) by Chi, Jung Hee, Roos, Jack, Dean, Neta

“…Sodium vanadate is an effective drug for the enrichment of yeast mutants defective in glycosylation reactions that are carried out in the Golgi complex(1). We…”
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ABCL-192 ACRUE: A Phase 2, Open-Label Study of Acalabrutinib in Combination With Rituximab in Elderly and/or Frail Patients With Treatment-Naive Diffuse Large B-Cell Lymphoma by Perini, Guilherme F., Graff, Tara, Roos, Jack, Hermann, Richard, Lovenklev, Magnus, Shaw, Bob, Budde, Lihua E.

“…Patients aged ≥80 years with diffuse large B-cell lymphoma (DLBCL) represent 18% of DLBCL cases in the United States (Morrison et al. Future Oncol. 2018)…”
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A Matching-Adjusted Indirect Comparison of Acalabrutinib with and without Obinutuzumab Versus Zanubrutinib in Treatment-Naïve Chronic Lymphocytic Leukemia by Allan, John N., Kittai, Adam S, James, Dan, Ridge, Helen, Miranda, Miguel, Yong, Alan, Fam, Fady, Roos, Jack, Shetty, Vikram, Davids, Matthew S., Skarbnik, Alan

“…Introduction The second-generation Bruton tyrosine kinase inhibitors acalabrutinib (acala) and zanubrutinib (zanu) have not been compared with each other in a…”
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Cumulative Review of Hypertension in Patients with Chronic Lymphocytic Leukemia (CLL) and Other Hematologic Malignancies Treated with Acalabrutinib by Ferrajoli, Alessandra, Follows, George, Marmor, Yotvat, Bourjlian, Shogheeg Apkarian, Roos, Jack, Bajwa, Naghmana, Madhira, Venkata, Nozaki, Kenji, Palhares De Miranda, Paulo Andre P., Patel, Krish

“…Background: Patients (pts) with CLL have a high rate of comorbidities, including cardiovascular disease (CVD). Comorbid CVD is correlated with higher mortality…”
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A matching-adjusted indirect comparison (MAIC) of the efficacy and safety of acalabrutinib (acala) versus zanubrutinib (zanu) in relapsed or refractory chronic lymphocytic leukemia (RR CLL) by Kittai, Adam, Skarbnik, Alan, Miranda, Miguel, Yong, Alan SM, Roos, Jack, Hettle, Robert, Palazuelos-Munoz, Sarah, Shetty, Vikram, Ghia, Paolo

“…7540 Background: The BTKi ibrutinib is the standard of care in RR CLL and was compared in head-to-head randomized clinical trials (RCTs) with second-generation…”
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